李雲志，男，2008年畢業於四川大學華西藥學院，獲博士學位。現在安徽中醫藥大學工作，教授，博士生導師，博士後合作導師。從事中藥學專業教學科研。
基本介紹
主持課題,研究方向,主要成就,部分論文,
主持課題
1.國家自然科學基金面上項目，從“腸道菌-琥珀酸-GPR91”軸研究紅檧木抗RA機制及藥效物質基礎，82174108，2022.1-2025.12，主持。
2.安徽省自然科學基金面上項目，基於非靶向代謝組學探討裂木脂素 Peperomins E 對前列腺癌裸鼠移植瘤模型代謝的干預，1808085MH248，2018.7-2021.6，主持。
3.安徽省高校自然科學基金重點項目：硬毛草胡椒誘導人前列腺癌PC-3細胞凋亡和周期阻滯活性成分和作用機制研究，KJ2015A132，2015.1-2016.12，主持.
研究方向
1.中藥活性成分分離鑑定
2.中藥活性成分作用機制
主要成就
近年來開展內源性代謝相關研究，如採用代謝組學技術研究了兩種中藥複方（清熱解毒方和涼血活血方）對膿毒症大鼠模型的代謝干預，其成果“An NMR metabolomics investigation of perturbations following treatment withChinese Herbal Medicine Formula in an experimental model of sepsis”在 OMICS: A Journal of IntegrativeBiology 雜誌發表。2018 年獲批一項安徽省自然科學基金面上項目“基於非靶向代謝組學探討裂木脂素 Peperomins E 對前列腺癌裸鼠移植瘤模型代謝的干預”（1808085MH 248）。
在中藥活性成分研究領域，近年來採用體內、體外模型，利用流式細胞術、western blot等技術對草胡椒屬藥用植物中的小分子次生代謝物 Peperomins E 抗腫瘤活性進行研究，發現其具有潛在的抗前列腺癌活性，其研究成果在老牌植物藥雜誌Planta Medica發表。此外，還對其他多種藥用植物，如豆瓣綠、刮金板、紅芪、祁白朮、紅楤木、Ajiga multiflora 、peperomia cavaleriei 等次生代謝成分進行結構鑑定，發現了多個結構新穎的化合物，如豆瓣綠中的環丁烷型降木脂素（Two New Norlignans and A New Lignanamide from Peperomia tetraphylla. Chemistry & Biodiversity, 2012, 9(4):769-776），祁白朮中的雙白朮內酯（New bisesquiterpenoid lactone from the wild rhizome of Atractylodes macrocephala Koidz grown in Qimen. Natural Product Research, 2017, 31(20): 2381-2386）。在此基礎上，對上述結構較為新穎的成分進一步進行活性及作用機制研究，相關成果在國內外相關雜誌，如：Journal of Ethnopharmacology, Journal of Pharmacological Sciences，Med Oncol，Natural Product Research，Chemistry & Biodiversity，Helvetica Chimica Acta，《中國中藥雜誌》，《中國藥學雜誌》，《中草藥》等藥學雜誌均有發表，熟悉中藥活性成分及分子機制研究方法。
部分論文
[1] Yunzhi Li*, Mingli Liang, Lu Ma, Qi Chen, Xian Huang. A novel Ursane-typetriterpene saponin from Ajuga multiflora.Natural Product Research, 2020, 34(2): 300-304.
[2] Yunzhi Li*, Ning He, Liqun Shen, Mingdong Liu. Apoptotic effect of Aralia echinocaulis extract on fibroblast-like synoviocytes in rats with adjuvant-induced arthritis via inhibiting the akt/hif-1α signaling pathway in vitro. Journal of Pharmacological Sciences, 2019, 139 : 340-345.
[3] Yunzhi Li*, Jigang Pan, Meng Gou*.The anti-proliferation, cycle arrest and apoptotic inducing activity of peperomin E on prostate cancer PC-3 cell Line. Molecules, 2019, 24(8), 1472.
[4] Yunzhi Li*, Jinlong Zhang, Mingdong Liu*. Chemical constituents of Peperomia cavaleriei,Chem Nat Compd, 2018, 54(1):147-148.
[5] Yunzhi Li, Hui Cheng, Ren Yue, Mengmeng Duan,Mingdong Liu*. New neolignan glycoside from the root of Aralia echinocaulis Hand. -Mazz. Natural Product Research, 2017,31(9): 1047-1051.
[6] Yunzhi Li*, Ren Yue, Ren Liu, Linjun Zhang, Ming Wang. Secondary metabolites from the root of Aralia echinocaulis Hand. -Mazz.Rec. Nat. Prod. 2016, 10 (5): 639-644.
[7] Yunzhi Li*, Min Dai*, Daiyin Peng. New bisesquiterpenoid lactone from the wild rhizome of Atractylodes macrocephala Koidz grown in Qimen. NaturalProduct Research,2017, 31(20): 2381-2386.
[8] Yunzhi Li*, Ning He, Cheng Wu Zhai. Peperotetraphin inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and apoptosis. Med Oncol. 2015, 32:22. doi: 10.1007/s12032-014-0468-8.
[9] Yunzhi Li, Hongbing Liu, Xianzhong Wu,Donghua Li, Jing Huang*. An NMR metabolomics investigation of perturbations following treatment with Chinese Herbal Medicine Formula in an experimental model of sepsis. OMICS: A Journal of Integrative Biology, 2013,17(5):252-258.
[10]Yun-Zhi Li*, Dai-Yin Peng*,Min Dai, Cao Mao Xiao, Hong Bo Jiang, Jing Huang. A new phenylpropanoid from Peperomia tetraphylla. Natural product research. 2013, 27(9):837-840.
[11]Yun-Zhi Li, Ai-Ping Tong, Jing Huang*. Two new norlignans and a new lignanamide from Peperomia tetraphylla. Chemistry & Biodiversity, 2012, 9(4):769-776.
[12] Yun-Zhi Li, Jing Huang*, Zhen Gong, Xiang-Qin Tian. A Novel Norlignan and a Novel Phenylpropanoid from Peperomoa tetraphylla. Helvetica Chimica Acta, 2007, 90(1):2222- 2226.
[13] 李雲志，馬超，黃靜*. 刮筋板的化學成分和抗腫瘤活性研究. 中國藥學雜誌，2009，44(17):1294-1297
[14] 李雲志，黃靜*，郭弘川，任波. 紅芪化學成分和抗腫瘤活性研究. 中草藥，2009，40(8):1195-1198.
[15] 李雲志，宮錚，馬超，馮小東，黃靜. 豆瓣綠的醯胺類化學成分[J]. 中國中藥雜誌，2010，35(04):468-469.
[16] MinLin, Qiannan Zhu, YunzhiLi*, JigangPan. Peperomin E Induces Apoptosis and Cytoprotective Autophagy in Human Prostate Cancer DU145 Cells In Vitro and In Vivo.Planta Medica, 2021,78, DOI: 10.1055/a-1348-1634.（通訊作者）
[17] Yunzhi Li*, Minxing Dai, Lulu Wang, Guodong Wang. Polysaccharides and glycosides from Aralia echinocaulis protect rats from arthritis by modulating the gut microbiota composition. Journal of Ethnopharmacology, 2021, 269 : 113749.
[18] 李雲志, 黃靜. 豆瓣綠非醯胺類化學成分研究. 中草藥, 2011, 42(9):1699-1601.
[19] 李雲志, 馬超, 黃靜. 刮筋板乙酸乙酯部位化學成分. 中國中藥雜誌, 2010, 9(9):1145-1145.
[20] 李雲志, 劉蘭花, 江洪波. 野生祁白朮化學成分的hplc-esi-tof/ms快速分離鑑別. 時珍國醫國藥, 2013, 24(012):2931-2932.
[21] 李雲志, 白雪. 祁白朮半野生和野生品以及和栽培品化學成分相似性初步研究. 時珍國醫國藥, 2012,23(9):2241-2242.
[22] Men Lei#, Li Yunzhi#, Wang Xiuli, Li Ruijun, Zhang Tao, Meng Xuesong, Liu S, Gong X, Gou M. Protein biomarkers associated with frozen Japanese puffer fish (Takifugu rubripes) quality traits. Food Chem. 2020 Oct 15;327:127002. doi: 10.1016/j.foodchem.2020.127002. Epub 2020 May 7. PMID: 32438262.（共同第一作者）
[23] Qiannan Zhu, Min lin, Wanying Zhuo, Yunzhi Li*. Chemical Constituents from the Wild Atractylodes macrocephala Koidz and Acetylcholinesterase Inhibitory Activity Evaluation as Well as Molecular Docking Study. Molecules 2021, 26, 7299. doi: 10.3390/molecules26237299. (通訊作者)
