李雅堂，男，畢業於南加州大學，現任北京腦科學與類腦研究中心研究員。主要研究方向為“視覺處理和行為的神經機制。”
基本介紹
- 中文名：李雅堂
- 畢業院校：南加州大學
人物經歷,科研成果,研究概述,發表論文,
人物經歷
2021 – 至今 研究員, 北京腦科學與類腦研究中心
2014 – 2021 博士後, 加州理工學院
科研成果
2019 – 2024 NIH Pathway to Independence Award (K99/R00)
2015 – 2018 Helen Hay Whitney Postdoctoral Fellowship
2013 國家優秀自費留學生獎學金
2013 Academic Professional Development Award
2011 Zach Hall Travel Award
研究概述
人類約一半的腦區處理跟視覺相關的信息。視覺處理始於視網膜：視網膜神經環路處理了大量湧入眼中的信息（~10億 bits/sec）。視網膜將處理過的信息輸送到兩個視覺中心：上丘—一個進化中保守的結構；視皮層—一個在哺乳動物中新出現的結構。視覺處理不僅可以使我們對所看到的內容產生連貫的感知，而且可以提取出極少量的特定信息（~20 bits/sec）來指導我們的行為。我們實驗室整合全細胞膜片鉗技術、雙光子和大視場成像，基於光遺傳學或者化學遺傳學的功能性擾動、神經建模和行為量化分析，來探索視覺處理的神經機制和計算原理。
我們的研究興趣包括：(1) 視覺信息在細胞群水平的編碼及其神經環路；(2) 視覺注意的神經機制；(3)視覺誘發的決策行為的神經環路；（4）生物啟發的計算機視覺。理解視覺處理的神經機制不僅可以揭示腦工作的原理，而且有助於對視覺疾病的理解和啟發新的人工智慧算法。
發表論文
*共同第一作者
#通訊作者
1. Li YT, Turan Z, and Meister M (2020) Functional architecture of motion direction in the mouse superior colliculus. Current Biology
2. Li YT, Fang Q, Zhang LI, and Tao HW (2018) Spatial Asymmetry and Short-Term Suppression Underlie Direction Selectivity of Synaptic Excitation in the Mouse Visual Cortex. Cerebral Cortex 28: 2059–2070.
3. Ibrahim LA, Mesik L, Ji XY, Fang Q, Li HF, Li YT, Zingg B, Zhang LI, and Tao HW (2016) Cross-modality sharpening of visual cortical processing through layer-1-mediated inhibition and disinhibition. Neuron 89: 1031–1045.
4. Li YT, Liu BH, Chou XL, Zhang LI, and Tao HW (2015) Synaptic Basis for Differential Orientation Selectivity between Complex and Simple Cells in Mouse Visual Cortex. J Neurosci 35: 11081–11093.
5. Li YT, Liu BH, Chou XL, Zhang LI, and Tao HW (2015) Strengthening of Direction Selectivity by Broadly Tuned and Spatiotemporally Slightly Offset Inhibition in Mouse Visual Cortex. Cerebral Cortex 25: 2466–2477.
6. Zhou M, Li YT, Yuan W, Tao HW, and Zhang LI(2014) Synaptic mechanisms for generating temporal diversity of auditory representation in the dorsal cochlear nucleus. J Neurophysiol 113: 1358–1368.
7. Li LY, Ji XY, Liang F, Li YT, Xiao Z, Tao HW, and Zhang LI (2014) A feedforward inhibitory circuit mediates lateral refinement of sensory representation in upper layer 2/3 of mouse primary auditory cortex. J Neurosci 34: 13670–13683.
8. Tao HW, Li YT, and Zhang LI (2014) Formation of excitation-inhibition balance: inhibition listens and changes its tune. Trends Neurosci 37:528–530.
9. Li YT, Ibrahim LA, Liu BH, Zhang LI, and Tao HW (2013) Linear Transformation of Thalamocortical input by Intracortical Excitation. Nat Neurosci 16: 1324–1330. (Featured with a preview in Nat Neurosci)
10. Li L.Y., Li YT, Zhou Mu, Tao HW, and Zhang LI(2013) Intracortical Multiplication of Thalamocortical Signals in Mouse Auditory Cortex. Nat Neurosci 16: 1179–1181. (Featured with a preview in Nat Neurosci)
11. Ma WP, Li YT, and Tao HW (2013) Down-regulation of Cortical Inhibition Mediates Ocular Dominance Plasticity During the Critical Period. J Neurosci 33: 11276–11280.
12. Li YT, Ma W.P., Li LY, Ibrahim LA, Wang SZ, and Tao HW (2012) Broadening of Inhibitory Tuning Underlies Contrast-Dependent Sharpening of Orientation Selectivity in Mouse Visual Cortex. J Neurosci 32:16466–16477.
13. Li YT, Ma WP, Pan CJ, Zhang LI, and Tao HW (2012) Broadening of Cortical Inhibition Mediates Developmental Sharpening of Orientation Selectivity. J Neurosci 32:3981–3991.
14. Liu BH, Li YT, Ma WP, Pan CJ, Zhang LI, and Tao HW (2011) Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells. Neuron 71:542–554.
15. Ma WP, Liu BH, Li YT, Huang ZJ, Zhang LI, and Tao HW (2010) Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses. J Neurosci 30: 14371–14379.
16. Liu BH, Li P.Y., Sun YJ, Li YT, Zhang LI, and Tao HW (2010) Intervening inhibition underlies simple-cell receptive field structure in visual cortex. Nature Neuroscience 13: 89–96.
17. Liu BH, Li PY, Li YT, Sun YJ, Yanagawa Y., Obata K, Zhang LI, and Tao HW (2009) Visual receptive field structure of cortical inhibitory neurons revealed by two-photon imaging guided recording. J Neurosci 29: 10520–10532.
18. Li YT, Qiu JH, Yang Z, Johns EJ, and Zhang T (2008) Long-range correlation of renal sympathetic nerve activity in both conscious and anesthetized rats. J Neurosci Methods 172: 131–136.
