李明雪

李明雪，女，1971年3月生，副教授，主要從事金屬配合物的設計和生物活性的基礎研究。重點是設計一些具有生物活性的配體及其金屬配合物，評價所合成的化合物的抗腫瘤活性及腫瘤治療選擇性的影響，初步分析配體的構效關係，分析金屬的引入對配體生物活性的影響，進一步篩選出抗癌譜廣，生物活性高、毒性小的金屬配合物，為新藥研究開發奠定基礎。

基本介紹

• 中文名：李明雪
• 出生日期：1971年3月
• 畢業院校：河南大學
• 職稱：副教授
• 性別：女

個人履歷

1991.9-1995.7河南大學化學系學士；

1995.7-1999.9河南省開封製藥廠助理工程師；

1999.9-2002.7河南大學無機化學碩士

2002.9-2005.6南京大學無機化學博士

2002.7至今，河南大學講師、副教授、碩士生導師、河南省教育廳學術技術帶頭人

主持項目

1. 2006年河南省科技廳計畫項目：茂鐵基金屬配合物的合成和性質研究（0611011900）；2006.1-2008.12；資助金額2萬元；即將結項

2. 2007年度河南省教育廳自然科學研究項目：氨基硫脲金屬配合物的合成和生物活性研究（2007150012）； 2007.1-2009.1；資助金額1萬元；即將結項

獲獎情況

1. 2006年獲省第九屆自然科學優秀論文獎

(1) Octanuclear metallocyclic Ni4Fc4 compound: Synthesis, crystal structure, and electrochemical sensing for Mg2+

(2) Organosilyl derivatives of trivacant tungstophosphate of general formula alpha-A-[PW9O34(RSiO)3(RSi)]3 Synthesis and structure determination by X-ray crystallography

2.2006年獲河南省教育廳科技論文獎

(1) Octanuclear metallocyclic Ni4Fc4 compound: Synthesis, crystal structure, and electrochemical sensing for Mg2+

(2) Heterodimetallic Compounds Assembled from Ferrocene-containing Bisthiosemicarbazone Clips

3. 2008年度河南省教育廳科技論文獎

(1) Heterodimetallic Compounds Assembled from Ferrocene-containing Bisthiosemicarbazone Clips

(2) Synthesis and crystal structure of a Mn(II) complex with thiosemicarbazone derivativeof pyridine-3-carbaldehyde showing unusual coordination modes of tridentate thiosemicarbazone

(3) Chiral aggregation and spontaneous resolution of thiosemicarbazone metal complexes

(4) Hydrothermal synthesis and crystal structure of a 1D fourfold-chain polyoxometalate-based complex[Cu(4,4ˊ-bipy)]2[SiW12O40{Cu(4,4ˊ -bipy)}4]∙(OH)2·H2O

4. 2008年榮獲河南省科學技術進步獎叄等獎1項

代表性論文

1. Ming-xue Li, Ping Cai, Chun-ying Duan, Feng Lu, Jin Xie, Qing-jin Meng Octanuclear Metallocyclic Ni4Fc4 Compound: Synthesis, Crystal Structure, and Electrochemical Sensing for Mg2+. Inorg. Chem. 2004, 43, 5174– 5176.

2. Ming-xue Li, Yan Bai, Bing-guang Zhang, Chun-ying Duan, Jian Xu, Qing-jin Meng，Heterometallic Compounds Assembled from Ferrocene-Containing Bisthiosemicarbazone Clips. Inorg. Chem. 2005，44，5459– 5466.

3. Ming-xue Li, Qiao-zhen Sun, Chun-ying Duan etal. Chiral aggregation and spontaneous resolution of thiosemicarbazone metal complexes. J. Chem. Soc., Dalton Trans. 2006, 2572–2578．

4. Ming-xue Li, Chun-ling Chen, Chun-sheng Ling, Jing Zhou, Bian-sheng Ji, Yan-juan Wu, Jing-yang Niu. Bioorganic & Medicinal Chemistry Letters, 2009，19，2704-2706.

5. Ming-xue Li, Jing Zhou , Hong Zhao , Chun-Ling Chen, Jing-ping Wang. Iron(III) Complex of 2-Acetylpyrazine Thiosemicarbazone: Synthesis, Spectral Characterization, Structural Studies and Antitumoral Activity. Journal of Coordination Chemistry,2009, , 6 2( 9) ， 1423 –1429.

6. Ping Cai, Ming-xue Li, Chun-ying Duan, Feng Lu, Qing-jin Meng . Synthesis and Properties of the Geometrically Controlled Mixed-Valence Tetrahedral RuII2RuIII 2L6 Cluster. Eur.J. Inorg. Chem. 2005 ，2581– 2585.

7. Ping Cai, Ming-xue Li, Chun-ying Duan, Feng Lu, Dong Guo and Qing-Jin Meng Syntheses, crystal structure and electrochemical properties of dinuclear ruthenium complexes containing saturated and unsaturated spacers New. J. Chem..2005，29，1011– 1016.

8. Ming-xue Li, Juan Du, Jing-Ping Wang, Jing-Yang Niu Hydrothermal synthesis and crystal structure of a 1D fourfold-chain polyoxometalate-based complex [Cu(4,4′-bipy)]2[SiW12O40{Cu(4,4′-bipy)}4] · (OH)2 · H2O. Inorg.Chem.Commun. 2007,10(12) 1391– 13931.

9. Ming-xue Li, Gui-ling Guo， Jing-yang Niu. A new organic-inorganic hybrid material constructed from Keggin polyanion and transition metal complexes: [Co(2,2'-bipy)3]1.5[SiWVWVI 11O40Co(2,2'-bipy)2(H2O)] · 0.5H2O J. Coord. Chem., 2008 , 61( 18)， 2896 – 2904

10. Ming-xue Li, Gui-ling Guo， Jing-yang Niu, A new hybrid material constructed from octamolybdate anion and neutral dinuclear copper units. J. Coord. Chem. 2008 , 61( 23)， 3860 – 3868.

11. Ming-xue Li, Jing Zhou , Hong Zhao , Chun-ling Chen, Jing-ping Wang. Iron(III) Complex of 2-Acetylpyrazine Thiosemicarbazone: Synthesis, Spectral Characterization, Structural Studies and Antitumoral Activity. J. Coord. Chem.,2009, , 6 2( 9) ， 1423 –1429.

12. Li Ming-Xue, Zhou Jing, Wang Jing-Ping，Wang, Zi-Liang. Synthesis and Crystal Structure of Mn（Ⅱ）Complex with Thiosemicarbazone Derivative of Pyridine-3-Carbaldehyde Showing Unusual Coordination Mode of Tridentate Thiosemicarbazone，Chinese J. Struct. Chem. 2006, 25, 1275– 1279.

13. Ming-xue Li, Jing Zhou, Jing-ping Wang, Zi-liang Wang. Antitumor Metallothiosemicarbazonate:Synthesis, Crystal Structure, Spectra and Antitumor Studies of Co(III) Complex withThiosemicarbazone Derivative of 2-Benzoylpyridine. Chinese J. Struct. Chem. 2008, 27(3), 281– 286.

14. Ming-xue Li, Jing Zhou, Zi Liang Wang, Jing-ping Wang. Synthesis, Crystal Structure and Antitumor Study of a Cobalt(II)Complex of the 2-Acetylpyrazine Thiosemicarbazone,Z. Naturforsch. 2008, 63b, 1 – 5.

15. Ming-xue Li, Jing Zhou, Chun-ling Chen, Jing- ping Wang. Synthesis, Crystal Structure and Antitumor Study of a Zinc Complex of the 2-Benzoylpyridine Thiosemicarbazone Ligand Z. Naturforsch. 2008, 63b, 280 – 284.

16. Ming-xue Li, Hong-yu Niu, Wei Wang, Jing-pingWang. A Keggin-type Arsenotungstate Anion-supported Transition Metal Complex: Hydrothermal Synthesis and Characterization of [Fe(2,2_-bipy)3]1.5[AsWVI10WV 2O40Fe(2,2_-bipy)2(H2O)] · 0.25H2O Z. Naturforsch. 2008, 63b, 183 – 186.

17. Ming-xue Li, Kai-hau Wang， Jing-yang Niu. Hydrothermal Synthesis and Crystal Structure of [Cu(en)2(H2O)]2{PW11.5Cu0.5O40[Cu(en)2]}·2H2O.Chinese J. Struct. Chem. 2008, 27(3), 340– 344.

18. 李明雪 ， 周靜，王子梁，王敬平. 一維單鏈4-吡啶甲醛縮氨基硫脲合鋅(Ⅱ)配位聚合物[Zn(HL)(CH3COO)2·H2O]n的合成、晶體結構及配體的新穎配位模式 套用化學，2008，25(1), 48– 52。