李慶順，男，博士，教授，畢業於美國肯塔基大學，廈門大學環境與生態學院院長。
基本介紹
- 中文名：李慶順
- 畢業院校：美國肯塔基大學
- 學位/學歷：博士
- 專業方向：植物學、生化遺傳、植物生理/分子生物
- 職務：院長
- 任職院校：廈門大學環境與生態學院
- 性別：男
個人經歷,研究方向,主講課程,學術成果,榮譽獎項,
個人經歷
教育經歷
1979/09 - 1983/07，廈門大學，植物學，理學學士
1983/09 - 1986/09，廈門大學，生化遺傳，理學碩士，導師：黃厚哲
1991/09 - 1995/09，美國肯塔基大學，植物分子生物學/生物化學，哲學博士，導師：Arthur G. Hunt
1995/10 - 1996/09，美國肯塔基大學，植物生理/分子生物學，博士後，導師：Arthur G. Hunt
工作經歷
1986/09 - 1988/11，廈門大學，生物系，助教
1989/12 - 1991/09，廈門大學，生物系，講師
1996/09 - 2001/07，美國肯塔基大學，菸草研發中心，研究員
2001/08 - 2007/06，美國邁阿密大學，植物學系，助理教授
2007/07 - 2010/06，美國邁阿密大學，植物學系，副教授（Tenured）
2010/07 - 2015/06，美國邁阿密大學，植物學系（後為生物學系），教授
2012/09 - 至今， 廈門大學，環境與生態學院院長，教授
研究方向
植物mRNA多聚腺苷化的分子生物學 （Plant mRNA Polyadenylation）
紅樹植物環境適應性的分子生態學 （Molecular Ecology of Mangrove Adaption）
生物信息學 （Bioinformatics）
主講課程
分子生物學基礎，分子生態學，遺傳與進化，生態之美，環境與生態組學技術
Molecular Biology, Molecular Ecology, Genetic and Evolution, Beauty of Ecosystem, Omic Technologies in Environment and Ecology
學術成果
環境適應性及分子生態學研究
1. Junjie Yin, Ming Zhou, Zeru Lin, Qingshun Q. Li, Yuan-Ye Zhang*. 2019.Transgenerational effects benefit offspring across diverse environments: a meta‐analysis in plants and animals. Ecology Letters, 22: 1976–1986.
2. Hongmei Qiao, Wenwen Liu, Yihui Zhang*,Yuanye Zhang*, Qingshun Q. Li*.2019.Genetic admixture accelerates invasion via provisioning rapid adaptiveevolution, Molecular Ecology. 28:4012-4027.
3. Wenyue Su, Congting Ye, Yihui Zhang, SaiqiHao, Qingshun Q. Li*.2019.Identification of putative key genes for coastal environments and coldadaptation in mangrove Kandelia obovatathrough transcriptome analysis. Science of the Total Environment.681:191–201. DOI: 10.1016/j.scitotenv.2019.05.127
4. Liwei Hong, Wenyue Su, Yuanye Zhang,Congting Ye, Yingjia Shen, Qingshun Q.Li*. 2018. Transcriptome profiling during mangrove viviparity in responseto abscisic acid. Scientific Reports, 8:770. DOI:10.1038/s41598-018-19236-x.
5. Liwei Hong, Liangjie Zhang, Meiling Liu,Shengjie Wang, Linjun He, Wanyu Yang, Jingli Li, Qiaojie Yu, Qingshun Q. Li* & Kefu Zhou*. 2018.Heavymetal rich stone-processing wastewater inhibits the growth and development of plants.International Journal of Phytoremediation. 21:5, 479-486, DOI:10.1080/15226514.2018.1537241
6. Neza Repar, Hao Li, Jose S. Aguilar, Qingshun Q. Li, Drobne Damjana, andYiling Hong*. 2018. Silver nanoparticles induce neurotoxicity in a humanembryonic stem cell-derived neuron and astrocyte network. Nanotoxicology, 12:104-116. DOI: 10.1080/17435390.2018.1425497
7. Luzhen Chen*, Wenqing Wang, Qingshun Q. Li, Yihui Zhang, ShengchangYang, Michael J. Osland, Jinliang Huang, and Congjiao Peng. 2017. Mangrovespecies’ responses to winter air temperature extremes in China.Ecosphere,8(6): e01865.DOI: 10.1002/ecs2.1865
8. Xiao-xuan Zhou, Ling-ling Cai, Mei-ping Fu,Li-wei Hong, Ying-jia Shen, Qingshun Q.Li*, 2016. Progress in the Studies of Vivipary on Mangrove Plants. ChineseJournal of Plant Ecology 40(12):1328-1343. 周曉旋, 蔡玲玲, 傅梅萍, 洪禮偉, 沈英嘉,李慶順*. 2016. 紅樹植物胎生現象研究進展, 植物生態學報,40(12):1328-1343. (In Chinesewith English abstract) Doi:10.17521/cjpe.2016.0087.
mRNA多聚腺苷化機理機制與生物信息學研究
9. Zhibo Yu, Juncheng Lin, Qingshun Q. Li*. 2019. Transcriptomeanalyses of FY mutants reveal its role in mRNA alternative polyadenylation. ThePlant Cell. 31(10):2332-2352.
10. Haihui Fu, Peng Wang, Xiaohui Wu, XiaoxuanZhou, Guoli Ji, Yingjia Shen, Yahui Gao, QingshunQ. Li*, Junrong Liang*. 2019. Distinct genome‐wide alternative polyadenylation during the responseto silicon availability in the marine diatom Thalassiosira pseudonana. The Plant Journal. 99(1):67-80. DOI:10.1111/tpj.14309
11. Congting Ye, Qian Zhou, Xiaohui Wu, GuoliJi, Qingshun Q. Li. 2019.Genome-wide alternative polyadenylation dynamics in response to biotic andabiotic stresses in rice. Ecotoxicology and Environmental Safety.183:109485.DOI: 10.1016/j.ecoenv.2019.109485.
12. Congting Ye, Qian Zhou, Xiaohui Wu, ChenYu, Guoli Ji, Daniel R Saban, Qingshun Q.Li. 2019. scDAPA: detection and visualization of dynamic alternativepolyadenylation from single cell RNA-seq data.Bioinformatics.
13. Congting Ye, Qian Zhou, Yiling Hong, Qingshun Q. Li. 2019.Role ofalternative polyadenylation dynamics in acute myeloid leukaemia at single-cellresolution. RNA Biology.16:6, 785-797. DOI: 10.1080/15476286.2019.1586139
14. Qian Zhou, Haihui Fu, Dewei Yang, CongtingYe, Sheng Zhu, Juncheng Lin, Wenbin Ye, Guoli Ji, Xinfu Ye, Xiaohui Wu*, Qingshun Q. Li*. 2019. Differentialalternative polyadenylation contributes to the developmental divergence betweentwo rice subspecies, japonica and indica. The Plant Journal. 98,260-276.
15. Jingyi Cao, Congting Ye, Guijie Hao, CaroleDabney-Smith, Arthur G. Hunt, Qingshun Q.Li*. 2019. Root hair single cell type specific profiles of gene expressionand alternative polyadenylation under cadmium stress. Frontiers in Plant Science.
16. Zhixin Zhao,Xiaohui Wu, Guoli Ji, Chun Liang, QingshunQ. Li*. 2019. Genome-wide comparative analyses of polyadenylation signalsin eukaryotes suggest a possible origin of the AAUAAA signal. InternationalJournal of Molecular Sciences. 20(4): 958. Doi: 10.3390/ijms20040958.
17. Congting Ye,Yuqi Long, Guoli Ji, Qingshun Q. Li*, Xiaohui Wu*. 2018.APAtrap: identification and quantification of alternative polyadenylation sitesfrom RNA-seq data. Bioinformatics,34(11):1841-1849. DOI:10.1093/bioinformatics/bty029
18. Liwei Hong, Congting Ye, Juncheng Lin,Haihui Fu, Xiaohui Wu and Qingshun Q. Li*.2018. Alternative polyadenylation is involved in auxin-based plant growth anddevelopment. Plant Journal, 93:246-258. doi: 10.1111/tpj.13771.
19. Juncheng Lin, Ruqiang Xu, Xiaohui Wu,Yingjia Shen and Qingshun Q. Li*. 2017. Role ofcleavage and polyadenylation specificity factor 100: anchoring poly(A) sitesand modulating transcription termination. Plant Journal, 91:829–839. DOI: 10.1111/tpj.13611
20. Cheng Guo,Matthew Spinelli, Congting Ye, Qingshun Q. Li* and ChunLiang*. 2017. Genome-Wide Comparative Analysis ofMiniature Inverted Repeat Transposable Element in 19 Arabidopsis thaliana Accessions. Scientific Reports, 7:2634. DOI: 10.1038/s41598-017-02855-1.
21. QingshunQ. Li*, Zhaoyang Liu,Wenjia Lu and Man Liu. 2017. Interplaybetween Alternative Splicing and Alternative Polyadenylation Defines theExpression Outcome of the Plant Unique OXIDATIVETOLERANT-6 Gene. Scientific Reports, 7:2052. DOI:10.1038/s41598-017-02215-z
22. Haihui Fu, Dewei Yang, Wenyue Su, LiuyinMa, Yingjia Shen, Guoli Ji, Xinfu Ye*, Xiaohui Wu*, Qingshun Q. Li*. 2016. Genome-wide Dynamics of AlternativePolyadenylation in Rice. GenomeResearch, 26: 1753-1760.Doi:10.1101/gr.210757.116
23. Xiaohui Wu*, Yumin Zhang, Qingshun Q. Li *. 2016. PlantAPA: aportal for visualization and analysis of alternative polyadenylation inplants. Frontiers in Plant Science,7:889. doi: 10.3389/fpls.2016.00889.
24. Cheng Guo,Matthew Spinelli, Man Liu, Qingshun Q. Li * and ChunLiang*. 2016. AGenome-wide Study of "Non-3UTR" Polyadenylation Sites in Arabidopsis thaliana. ScientificReport, 6:28060; doi:10.1038/srep28060 (2016).
25. Xiaohui Wu*, Yong Zeng, Jinting Guan,Guoli, Ji,Rongting Huang, QingshunQ. Li*.2015. Genome-wideCharacterization of Intergenic Polyadenylation Sites Redefines Gene Spaces inArabidopsis thaliana. BMC Genomics. 16:511. DOI:10.1186/s12864-015-1691-1
26. Guoli Ji, Jinting Guan, Yong Zeng, Qingshun Q. Li and Xiaohui Wu*. 2015.Genome-wide identification and predictive modeling of polyadenylation sitesin eukaryotes. Briefingsin Bioinformatics. 16(2): 304-313. DOI: 10.1093/bib/bbu011
27. Guoli Ji, Lei Li, Qingshun Q. Li, Xiangdong Wu, Jingyi Fu, Xiaohui Wu*. 2015. PASPA:a web server for mRNA poly(A) site predictions in plants and algae. Bioinformatics,31(10):1671-3. doi:10.1093/bioinformatics/btv004.
28. Jinting Guan, Jingyi Fu, Mingcheng Wu,Longteng Chen, Guoli Ji, Qingshun Q. Li,Xiaohui Wu*. 2015. VAAPA: A web platform for visualization and analysis ofalternative polyadenylation. Comput Biol Med. 57:20-25. doi:10.1016/j.compbiomed.2014.11.010
29. Man Liu, Ruqiang Xu, Carrie Merrill, LiweiHong, Carol Von Lanken, Arthur G. Hunt* and QingshunQ. Li*. 2014. Integration of developmental andenvironmental signals via a polyadenylation factor in plants. PloSOne. 9: e115779.doi:10.1371/journal.pone.0115779.
30. Xiaohui Wu, Bobby Gaffney, Arthur G. Hunt*,and Qingshun Q. Li*. 2014.Genome-wide determination of poly(A) sites in Medicago truncatula: evolutionary conservation of alternative poly(A)site choice. BMC Genomics. 15:615. DOI: 10.1186/1471-2164-15-615.
31. Zhixin Zhao, Xiaohui Wu, Praveen Kumar RajKumar, Min Dong, Guoli Ji, QingshunQ. Li* and Chun Liang*. 2014. Bioinformaticsanalysis of alternative polyadenylation in green alga Chlamydomonas reinhardtii using transcriptome sequences from threedifferent sequencing platforms. Genes Genomics Genetics (G3).4:871-883. DOI:10.1534/g3.114.010249
32. Liuyin Ma, Pratap Kumar Pati, Man Liu, Qingshun Q. Li* and Arthur G. Hunt*.2014. High throughput characterizations of poly(A) site choice in plants. Methods.67:74-83.
33. Liuyin Ma, Cheng Guo and Qingsun Q. Li*. 2014. Role ofalternative polyadenylation in epigenetic silencing and antisilencing. Proc.Nat. Acad. Sci. USA, 111:9-10. DOI: 10.1073/pnas.1321025111
34. William C Ray*, Samuel L Wolock, Nicholas WCallahan, Min Dong, Qingshun Q. Li,Chun Liang, Thomas J. Magliery and Christopher W. Bartlett. 2014. Addressingthe unmet need for visualizing Conditional Random Fields in Biological Data. BMC Bioinformatics. 15:202.
35. Guoli Ji*, Yong Zeng, Jinting Guan, Qingshun Q. Li, Congting Ye, Yunlong Liu. 2013. Recent advances in mathematicalmodeling and simulation of DNA replication process. Current Bioinformatics.8:591-602. DOI: 10.2174/15748936113088880005
36. Denghui Xing, Yajun Wang, Ruqiang Xu, XinfuYe, Dewei Yang, Qingshun Q. Li*.2013. The Regulatory Role of Pcf11-Similar-4 (PCFS4) in Arabidopsis Developmentby Genome-Wide Physical Interactions with Target Loci. BMC Genomics. 14:598. DOI:10.1186/1471-2164-14-598
37. Patrick E.Thomas, Xiaohui Wu, Man Liu,Bobby Gaffney, Guoli Ji, Qingshun Q. Li andArthur G. Hunt*. 2012. Genome-wide control of poly(A) site choice by CPSF30 in Arabidopsis. Plant Cell. 24: 4376-4388. DOI:10.1105/tpc.112.096107
38. Arthur G. Hunt,Denghui Xing*, Qingshun Q. Li*. 2012. Plant polyadenylation factors:conservation and variety. BMC Genomics. 13:641. DOI:10.1186/1471-2164-13-641
39. Xiaohui Wu, Guoli Ji*, Qingshun Q.Li and Sun Zhou. 2012. Comprehensive recognition ofmessenger RNA polyadenylationpatterns in plants. Afr. J. Biotech, 11:3215-3234. DOI:10.5897/AJB10.2539
40. Hongwei Zhao, Jun Zheng, Qingshun Q. Li*. 2011.A novel plantin vitro assay system for pre-mRNAcleavage and polyadenylation. Plant Physiology, 157:1546-1554. DOI: 10.1104/pp.111.179465
41. Yingjia Shen, R. C. Venu, Kan Nobuta, Xiaohui Wu, Varun Notibula, CaghanDemirci, Blake C Meyers, Guo-Liang Wang, Guoli Ji, Qingshun Q. Li*. 2011. TranscriptomeDynamics Through Alternative Polyadenylation in Developmental and EnvironmentalResponses in Plants Revealed by Deep Sequencing. Genome Research, 21:1478-1486. DOI: 10.1101/gr.114744.110
42. Xiaohui Wu, Man Liu, Bruce Downie, Chun Liang,Guoli Ji, Qingshun Q. Li*, ArthurHunt*. 2011. The genome-wide landscape ofpolyadenylation in Arabidopsis provides evidence for extensive alternativepolyadenylation. Proc. Nat. Acad. Sci. USA, 108:12533–12538. doi/10.1073/pnas.1019732108
43. Jianti Zheng,Denghui Xing, Xiaohui Wu, Diana Kroll, Yingjia Shen, Guoli Ji, Qingshun Q. Li*. 2011.Ratio-based analysis of differential mRNA processing and expression of apolyadenylation factor mutant pcfs4using Arabidopsis tiling microarray. PLoS One, 6:e14719.DOI: 10.1371/journal.pone.0014719
44. Denghui Xing, Qingshun Q. Li*. 2011. Alternative polyadenylation and gene expression regulation in plants. WIREs(Willey InterdisciplinaryReviews) RNA, 2:445-458. (Invitedreview) DOI: 10.1002/wrna.59
45. Guoli Ji, Xiaohui Wu, Yingjia Shen, Jiangyin Huang and Qingshun Q. Li*. 2010. A Classification-Based Prediction Models of Messenger RNAPolyadenylation Sites. Journalof Theoretical Biology, 265:287-296. DOI: 10.1016/j.jtbi.2010.05.015
46. Guoli Ji*, Xiaohui Wu, Jiangyin Huang, Qingshun Q. Li. 2010. Implementation ofa Classification-Based Prediction Model for Plant mRNA Poly(A) Sites. Journalof Computational and Theoretical Nanoscience, 7(5):927-932. DOI: 10.1166/jctn.2010.1440
47. Hongwei Zhao,Denghui Xing, Qingshun Q. Li*. 2009. Unique features of plant cleavage andpolyadenylation specificity factor revealed by proteomic studies. PlantPhysiology, 151:1546-1556. DOI: 10.1104/pp.109.142729
48. Denghui Xing,Hongwei Zhao and Qingshun Q. Li*. 2008. Arabidopsis CLP1-Similar Protein3, an ortholog of human polyadenylationfactor CLP1, functions in gametophyte, embryo and post-embryonic development. PlantPhysiology, 148:2059-2069. doi/10.1104/pp.108.129817
49. Yingjia Shen,Yuansheng Liu, Lin Liu, Chun Liang, and QingshunQ. Li*. 2008. Unique features of nuclear mRNApoly(A) signals and alternative polyadenylation in Chlamydomonas reinhardtii. Genetics,179:167-176. DOI:10.1534/genetics.108.088971
50. Denghui Xing, Hongwei Zhao, Ruqiang Xu and Qingshun Q. Li*. 2008. Arabidopsis PCFS4, a homologue of yeast polyadenylation factorPcf11p, regulates FCA alternative processing and promotes flowering time. Plant Journal, 54:899-910. DOI: 10.1111/j.1365-313X.2008.03455.x
51. Arthur G. Hunt*, Ruqiang Xu, Balasubrahmanyam Addepalli, Suryadevara Rao, Kevin P.Forbes, Lisa R. Meeks, Denghui Xing, Min Mo, Hongwei Zhao, AmritaBandyopadhyay, Lavanya Dampanaboina, Amanda Marion, Carol Von Lanken, and Qingshun Q. Li*. 2008.Arabidopsis mRNA polyadenylation machinery: comprehensive analysis ofprotein-protein interactions and gene expression profiling. BMCGenomics, 9:220. DOI: 10.1186/1471-2164-9-220Highly Accessed
52. Yingjia Shen,Guoli Ji, Brian J. Haas, Xiaohui Wu, Jianti Zheng, Greg J. Reese, and Qingshun Q. Li*. 2008. Genomelevel analysis of rice mRNA 3’-end processing signals and alternativepolyadenylation. Nucleic Acids Research, 36:3150-3161. DOI:10.1093/nar/gkn158
53. Jingxian Zhang, Kil-YoungYun, Ruqiang Xu, Arthur G. Hunt, Irina Artiushin, Kim Delaney, Qingshun Q. Li and Deane L. Falcone*. 2008. A Polyadenylation FactorSubunit Implicated in Regulating Oxidative Signaling in Arabidopsis thaliana.PLoSOne, 3:e2410. DOI: 10.1371/journal.pone.0002410
54. Chun Liang*, Yuansheng Liu, Lin Liu, Adam C. Davis, YingjiaShen, and Qingshun Q. Li. 2008. Expressedsequence tags with cDNA termini – previously overlooked resources for geneannotation and transcriptome exploration in Chlamydomonasreinhardtii. Genetics, 179:83-93. DOI: 10.1534/genetics.107.085605
55. Guoli Ji, JiantiZheng, Yingjia Shen, Xiaohui Wu, Ronghan Jiang, Yun Lin, Johnny C. Loke,Kimberly M. Davis, Greg J. Reese and QingshunQ. Li*. 2007. Predictive modeling of plant messenger RNA polyadenylation sites. BMCBioinformatics, 8:43. DOI: 10.1186/1471-2105-8-43 Highly Accessed
56. Guoli Ji, XiaohuiWu, Jianti Zheng, Yingjia Shen and Qingshun Q. Li*. 2007. Modeling Plant mRNA Poly(A) sites: SoftwareDesign and Implementation. Journalof Computational and Theoretical Nanoscience, 4:1365-1368. DOI:10.1166/jctn.2007.025
57. Kim Delaney,Ruqiang Xu, Jingxian Zhang, Qingshun Q.Li, Kil-Young Yun, Deane L. Falcone and Arthur G. Hunt*. 2006. Calmodulin interacts with and regulates the RNA-binding activity of an Arabidopsispolyadenylation factor subunit. Plant Physiology, 140:1507-1521. DOI: 10.1104/pp.105.070672
58. BalasubrahmanyamAddepalli, Ruqiang Xu, Tomal Dattaroy, Baochun Li, W. Troy Bass, Qingshun Q. Li and Arthur G. Hunt*. 2006. Disease resistance in plants that carry afeedback-regulated yeast poly(A) binding protein gene. Plant Molecular Biology,61:383 - 397. DOI: 10.1007/s11103-006-0019-6
59. Ruqiang Xu,Hongwei Zhao, Randy Dinkins, Xiaowen Cheng, George Carberry and Qingshun Q. Li*. 2006. The 73 kD subunit of thecleavage and polyadenylation specificity factor (CPSF) complex affectsreproductive development in Arabidopsis. Plant Molecular Biology, 61:799-815.DOI: 10.1007/s11103-006-0051-6
60. Johnny C. Loke,Eric Stahlberg, Dave Strenski, Brian J. Haas, P. Chris Wood and Qingshun Q. Li*. 2005. Compilation of mRNA Polyadenylation Signalsin Arabidopsis Revealed a New Signal Element and Potential SecondaryStructures.Plant Physiology, 138: 1457-1468. DOI: 10.1104/pp.105.060541
其他
61. Dewei Yang, Xinfu Ye*, Xianghua Zheng, Chaoping Cheng, Ning Ye, Libin Lu, Fenghuang Huang, Qingshun Q. Li *. 2016. Identification and fine mapping of LD1,a single recessive gene playing an essential role in thedevelopment of lemma in rice. J. Agricultural Science 154(6)989-1001.DOI:10.1017/S0021859615000866
62. David A. Francko*, Kenneth G. Wilson, Qingshun Q.Li and Alejandra Equiza. 2011. A topical spray to enhance plant resistanceto cold injury and mortality. HortTechnology, 21:109-118.
63. Denghui Xing,Shuisong Ni, Michael A. Kennedy, QingshunQ. Li*. 2009. Identification of a plant-specificZn-sensitive ribonuclease activity. Planta, 230:819-825. DOI 10.1007/s00425-009-0986-3
64. Ruqiang Xu and Qingshun Q. Li*. 2008.Streamline cloning of genes into binary vectors in Agrobacterium via the Gateway® TOPO vector system. PlantMethods, 4:4. DOI: 10.1186/1746-4811-4-4
65. Hongyan Xing,Orlando Chambers, Chris B. Lawrence, H. Maelor Davies, Nicholas P. Everett and Qingshun Q. Li*. 2006. Increasedpathogen resistance and yield in transgenic plants expressing combinations ofthe modified antimicrobial peptides based on indolicidin and magainin. Planta,223:1024-1032. DOI: 10.1007/s00425-005-0143-6
榮譽獎項
1、Sigma Xi-全美科學研究協會評為“最佳研究者”（2011）。
2、被邁阿密大學評為“傑出學者”（2012）。
3、美國肯塔基大學植物學系傑出校友獎（2014）。
4、曾兩度做為海外優秀華人學者代表應邀在天安門參加中華人民共和國成立50周年與60周年慶典，受中央領導接見。
5、福建省高層次引進創新創業人才
6、廈門市雙百計畫人才
