李惠(中山大學生命科學學院教授)

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李惠，女，博士，中山大學生命科學學院教授、博士生導師。

基本介紹

  • 中文名：李惠
  • 學位/學歷：博士研究生
  • 專業方向：細菌耐藥與逆轉調節的代謝機制等
  • 任職院校：中山大學
研究方向,學術成果,承擔課題,論文專著,

研究方向

細菌耐藥與逆轉調節的代謝機制
宿主抗耐藥菌感染的代謝機制

學術成果

承擔課題

  1. 國家自然基金面上項目: 《遲緩愛德華氏菌宿主整合因子調節TolC耐藥外排泵的研究》(31772888)，2018.01-2021.12
  2. 國家自然基金面上項目: 《溶藻弧菌NQR蛋白複合物耐藥的研究》(31472283)，2015.01-2019.12
  3. 廣東省自然科學基金-重大基礎研究培育項目:《弧菌質子動力勢產生關鍵酶的耐藥機制與調節研究》(2015A030308009),2015.8-2019.8
  4. 國家自然基金面上項目: 《弧菌和遲鈍愛德華菌 DNA 改組多價疫苗及其分子機制》(31272702)2013.01-2016.12
  5. 國家“973”計畫課題子課題：魚類疫病免疫防治的系統疫苗學原理與技術途徑（2012CB114406），2012.1-2016.12
  6. 國家自然基金面上項目: 《溶藻弧菌外膜耐藥功能蛋白組的研究》(40976080)2010.01-2012.12
  7. 國家863重點項目子課題: 《遲鈍愛德華氏菌毒力相關功能基因研究及疫苗開發》(2008AA092501), 2009.7-2012.12
  8. 國家863重點項目:《海水養殖魚類OmpA免疫增強劑的套用研究》(2007AA091405)2007.12-2010.12
  9. 國家“973”計畫課題子課題：《魚類多價疫苗的設計與套用策略》（2006CB101807）, 2006－2010

論文專著

  1. Yang J, Cheng ZX#, Zeng ZH, Yang MJ, Li D, Lai SS, Peng XX, Li H*. NaCl promotes antibiotic resistance through reducing redox states inVibrio alginolyticus. Environ. Microbiol. 2018，in press
  2. Peng B, Lin XP, Wang SN, Yang MJ, Peng XX, Li H*. Polyvalent protective immunogens identified from outer membrane proteins ofVibrio parahaemolyticus and their induced innate immune response.Fish Shellfish Immunol.2018，72:104-110
  3. Wang SN,Cheng ZX,Ling XP,Chu X,Peng XX*,Li H* Construction, immune protection and innate immune response of shuffled polyvalent ompAs vaccines.Fish Shellfish Immunol.2018,74:325-331
  4. Su YB#, Peng B#, Li H#, Cheng ZX#, Zhang TT, Zhu JX, Li D, Li MY, Ye JZ, Du CC, Zhang S, Zhao XL, Yang MJ, Peng XX*. Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria.PNAS 2018,115(7):E1578-E1587
  5. Cheng ZX, Chu X, Wang SN, Peng XX*, Li H*. Six of ompA genes family shuffling for development of polyvalent vaccines againstVibrio alginolyticusandEdwardsiella tarda.Fish Shellfish Immunol.2018,75:308-315
  6. Yang MJ, Cheng ZX, Jiang M, Zeng ZH, Peng B, Peng XX, Li H*. Boosted TCA cycle enhances survival of zebrafish toVibrio alginolyticusinfection. Virulence,2018.9(1):634-644
  7. Zhang DF, Ye JZ, Dai HH, Lin XM, Li H*, Peng XX*. Identification of ethanol tolerant outer membrane proteome reveals OmpC-dependent mechanism in a manner of EnvZ/OmpR regulation in Escherichia coli.J Proteomics2018,179:92-99
  8. Cheng ZX, Yang MJ, Peng B, Peng XX, Lin XM*, Li H*. The depressing central carbon and energy metabolisms mediatelevofloxacinresistance inVibrio alginolyticus.J Proteomics2018, 181:83-91
  9. Liu X, Yang MJ, Li H*, Peng XX*. Differential antibody responses to outer membrane proteins contribute to differential immune protections between live and inactivatedVibrio parahaemolyticus.J Proteome Res. 2018,17:2987-2994
  10. Li H#,Zhu QF#,Peng XX,Peng B*. Interactome ofE. piscicidaand grouper liver proteins reveals strategies of bacterial infection and host immune response. Sci. Rep.2017, 7:39824
  11. Li H#*, Chu X, Li D, Zeng ZH, Peng XX*. Construction and immune protection evaluation of recombinant polyvalent OmpAs derived from genetically divergent ompA by DNA shuffling.Fish Shellfish Immunol.2016,49:230-236
  12. Peng B#, Su YB#, Li H#, Han Y, Guo C, Tian YM, Peng XX*.Exogenousalanineand/orGlucosepluskanamycinkillsantibiotic-resistantbacteria.Cell Metab. 2015, 21(2):249-261
  13. Peng B, Ma YM, Zhang JY, Li H*. Metabolome strategy againstEdwardsiella tardainfection through glucose-enhanced metabolic modulation intilapias.Fish Shellfish Immunol.2015,45:869-876
  14. Ma YM, Yang MJ, Wang SY, Li H*, Peng XX*. Liver functional metabolomics discloses an action of L-leucine againstStreptococcus iniaeinfection intilapias.Fish Shellfish Immunol.2015,45:414-421
  15. Peng B, Li H, Peng XX*. Functional metabolomics: from biomarker discovery to metabolome reprogramming. Protein cell 2015,6(9):628-637
  16. Guo C,Peng B,Song M,Wu CW,Yang MJ,Zhang JY,Li H*. LiveEdwardsiellatardavaccineenhancesinnateimmunitybymetabolicmodulationinzebrafish.Fish Shellfish Immunol.2015,47(2):664-673
  17. Zhao XL,Wu CW,Peng XX*,Li H*. Interferon-α2b against microbes through promoting biosynthesis of unsaturated fatty acids.J Proteome Res.2014,13(9):4155-4163
  18. Cheng ZX,Ma YM,Li H*,Peng XX*. N-acetylglucosamine enhances survival ability oftilapiasinfected byStreptococcus iniae.Fish Shellfish Immunol.2014,40:524-530
  19. Song M, Xie J, Peng XX, Li H*. Identification of protective immunogens from extracellular secretome ofEdwardsiella tarda. Fish Shellfish Immunol. 2013，35(6): 1932-1936
  20. Liu X,She XT,Zhu QF,Li H*,Peng XX*. Heterogeneous interactome betweenLitopenaeus vannameiplasma proteins andVibrio parahaemolyticusouter membrane proteins.Fish Shellfish Immunol.2013,34(1):192-198
  21. Zhang HL, Liu XJ, Zhang BW, Peng XX, Li H*. Amphioxus CaVPT and creatine kinase are crucial immune-related molecules in response to bacterial infection and mmunization.Fish Shellfish Immunol.2012, 33：1139-1148
  22. Li H, Pan JY, Liu XJ, Gao JX, Wu HK, Wang C, Peng XX*.Alterations of protein complexes and pathways in genetic information flow and response to stimulus contribute toEscherichia coliresistance to balofloxacin.Mol. BioSyst. 2012,8, 2303–2311
  23. Lin XM, Wang C, Guo C, Tian YM, Li H*, Peng XX*. Differential regulation of OmpC and OmpF by AtpB inEscherichia coliexposed to nalidixic acid and chlortetracycline. J Proteomics 2012,75:5898-5910
  24. Li PP, Liu XJ, Li H, Peng XX*. Downregulation of Na(+)–NQR complex is essential forVibro Alginolyticusin resistance to balofloxacin. J Proteomics 2012; 75(4):2638-2648
  25. Yang JN,Wang C,Guo C,Peng XX, Li H*. Outer membrane proteome and its regulation networks in response to glucose concentration changes inEscherichia coli.Mol. Biosyst.2011, 7:3087-3093
  26. Wang HB, Zhang ZX#, Li H#, He HB, Fang CX, Zhang AJ, Li QS, Chen RS, Guo XK, Lin HF, Wu LK, Lin S, Chen T, Lin RY, Peng XX, Lin WX*. characterization of metaproteomics in crop rhizospheric soil. J. Proteome Res. 2011,10:932-940
  27. Lin XM, Yang JN, Peng XX,Li H*.A novel negative regulation mechanism of bacterial outer membrane proteins in response to antibiotic resistance. J. Proteome Res. 2010,9:5952-5959
  28. Pan JY, Li H#, Ma Y, Chen P, Zhao P, Wang SY, Peng XX*. Complexome ofEscherichia colienvelope proteins under normal physiological conditions.J. Proteome Res. 2010, 9:3730–3740
  29. Xiong XP, Ye MZ, Peng XX, Li H*.Identification of vaccine candidates from differentially expressed outer membrane proteins ofVibrio alginolyticusin response to NaCl and iron-limitation.Fish Shellfish Immunol. 2010, 29(5):810-816
  30. Li H, Ye MZ, Peng B, Wu HK, Xu CX, Xiong XP, Wang C, Wang SY, Peng XX*. Immunoproteomic identification of polyvalent vaccine candidates fromVibrio parahaemolyticusouter membrane proteins J. Proteome Res. 2010，9(5):2573-2583
  31. Xiong XP，Wang C，Ye MZ，Yang TC, Zhang Yl，Peng XX，Li H*.　Differentially expressed outer membrane proteins of Vibrio alginolyticus in response to six types of antibiotics. Mar Biotech, 2010, 12 ( 6 ): 686-695
  32. Li H, Xiong XP, Peng B, Xu CX, Ye MZ, Yang TC, Wang SY, and Peng XX*. Identification of broad cross-protective immunogens using heterogeneous antiserum-based immunoproteomic approach. J Proteome Res. 2009, 8:4342–4349
  33. Li H, Wang BC, Xu WJ, Lin XM, Peng XX*. Identification and network of outer membrane proteins regulating streptomysin-resistance inEscherichia coli.J Proteome Res. 2008,7:4040-4049
  34. Lin XM，Li H#，Wang C, Peng XX*. Proteomic analysis of nalidixic acid resistance inEscherichia coli: Identification and functional characterization of OM proteins. J Proteome Res. 2008, 7:2399–2405
  35. Lin XM, Wu LN,Li H, Peng XX*.Down-regulation of Tsx and OmpW and up-regulation of OmpX are required for iron homeostasis inEscherichia coli.J Proteome Res. 2008,7:1235-1243
  36. Li H, Lin XM, Wang SY, Peng XX*. Identification and antibody-therapeutic targeting of chloramphenicol-resistant outer membrane proteins inEscherichia coli. J. Proteome Res. 2007, 6:3628-3636

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