李建梅(南京大學生命科學學院副教授)

李建梅，博士，南京大學生命科學學院副教授。

基本介紹

• 中文名：李建梅 
• 畢業院校：南京大學
• 學位/學歷：博士
• 職稱：副教授
• 任職院校：南京大學生命科學學院

人物經歷

2011/01 - 至今，南京大學，生命科學學院，副教授

2015/05 - 2016/05，美國華盛頓大學醫學院，訪問學者

2008/12 - 2010/12，南京大學，生命科學學院，講師

2006/09 - 2008/12, 南京大學，生命科學學院，博士後

學術兼職

1. 中國藥理學會會員

2. 《中國天然藥物》(The Chinese Journal of Natural Medicines, CJNM)青年編委

研究方向

1. 代謝性疾病及抑鬱症的發病機制及中藥干預;

2. 代謝紊亂引起中樞神經系統損傷的分子機制及藥物干預;

3. 腸道菌群對中樞神經系統的影響及機制。

獲獎情況

2012年獲得江蘇省“六大人才高峰”高層次人才項目

科研成果

1. Song L#, Chen TY#, Zhao XJ, Xu Q, Jiao RQ, Li JM[李建梅] *, Kong LD*. Pterostilbene prevents hepatocyte EMT in fructose‐induced liver fibrosis through suppressing miR‐34a/Sirt1/p53 and TGF‐β1/Smads signaling. British Journal of Pharmacology. Br J Pharmacol. 2019, in press.

2. Li JM[李建梅], He X, Yang Y, Li M, Xu C, Yu R. Risk assessment of silica nanoparticles on liver injury in metabolic syndrome mice induced by fructose. Sci Total Environ. 2018; 628-629:366-374.

3. Xu MX, Yu R, Shao LF, Zhang YX, Ge CX, Liu XM, Wu WY, Li JM[李建梅] *, Kong LD*. Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin. Brain Behav Immun. 2016, S0889-1591(16)30001-0. 6.3

4. Ge CX, Yu R, Xu MX, Li PQ, Fan CY, Li JM[李建梅]*, Kong LD*. Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. Eur J Pharmacol. 2016; 770:154-64.

5. Li JM[李建梅], Ge CX, Xu MX, Wang W, Yu R, Fan CY, Kong LD*. Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats. Mol Nutr Food Res. 2015, 59(2):189-202. 5.1

6. Fan CY, Wang MX, Ge CX, Wang X, Li JM[李建梅]*, Kong LD*. Betaine supplementation protects against high-fructose-induced renal injury in rats. J Nutr Biochem. 2014, 25(3):353-62.

7. Li JM[李建梅], Wang W, Fan CY, Wang MX, Zhang X, Hu QH, Kong LD*. Quercetin Preserves β-Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation. Evid Based Complement Alternat Med. 2013, 2013:303902.

8. Li JM[李建梅], Zhang X, Wang X, Xie YC, Kong LD. Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice. Eur J Pharmacol. 2011, 666(1-3):196-204.

9. Li JM[李建梅], Li YC, Kong LD*, Hu QH. Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology. 2010, 51(5): 1555-1566.

10. Li JM[李建梅], Che CT, Lau CBS, Leung PS and Cheng HK*. Desoxyrhaponticin inhibits glucose uptake in the intestine and kidney: a potential agent in the control of postprandial hyperglycemia. J Pharmacol Exp Ther. 2007, 320(1): 38-46.

11. Li JM[李建梅], Che CT, Lau CBS, Leung PS and Cheng HK*. Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin. Int J Biochem Cell B. 2006 (38): 985-995.

12. Li JM[李建梅], Kong LD*, Wang YM, Cheng HK, Zhang WY and Tan WZ. Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction. Life Sci. 2003, 74(1): 55-73. Models