朱蕾蕾，博士，畢業於江南大學，現任中國科學院天津工業生物技術研究所研究員。
基本介紹
- 中文名：朱蕾蕾
- 國籍：中國
- 畢業院校：江南大學
- 職業：科研工作者
人物簡介,代表論著,科研項目,
人物簡介
1、教育經歷
2001.09-2005.06，中國，江南大學，生物工程，學士學位
2005.09-2007.06，中國，江南大學，生物化工，碩士學位
2007.07-2009.06，德國，不萊梅雅各布大學（Jacobs University Bremen），生物技術，博士學習
2009.07-2010.09，德國，亞琛工業大學（RWTH Aachen University），生物技術，博士學位
2、工作經歷
2011.01-2016.07，德國，亞琛工業大學（RWTH Aachen University），研究小組組長 （subgroup leader）
2016.08-至今，中國科學院天津工業生物技術研究所，蛋白質定向進化研究組組長
代表論著
1、論文
1. Cheng F., Yang J., Schwaneberg U., Zhu L. Rational surface engineering of an arginine deiminase (an antitumor enzyme) for increased PEGylation efficiency. Biotechnology and Bioengineering, 2019, DOI: 10.1002/bit.27011.
2.Anand D., Dhoke G. V., Kinzel J., Garakani T. M., Davari M. D., Bocola M., Zhu L. and Schwaneberg U.. Chiral separation of D/L-arginine with whole cells through an engineered FhuA nanochannel. 2019,55, 5431-5434.
3. Frauenkron？Machedjou V. J., Fulton A., Zhao J., Weber L., Jaege K.？E. , Schwaneberg U., and Zhu L. Exploring the full natural diversity of single amino acid exchange reveals that 40-60% of BSLA positions improve organic solvents resistance. Bioresource and Bioprocessing, 2018, 5:2.
4. Cheng F., Yang J., Bocola M., Schwaneberg U.,Zhu L. Loop engineering reveals the importance of active-site-decorating loops and gating residue in substrate affinity modulation of arginine deiminase (an anti-tumor enzyme). Biochemical and Biophysical Research. 2018, 499(2), 233-238.
5. Markel U.*, Zhu L.*, Frauenkron-Machedjou V. Zhao J., J., Bocola M., Davari M. D., Jaeger K.E., Schwaneberg U. Are Directed Evolution Approaches Efficient in Exploring Nature’s Potential to Stabilize a Lipase in Organic Cosolvents? Catalysts, 2017, 7(5), 142.
6. Charan H., Glebe U., Anand D., Kinzel J., Zhu L., Bocola M., Garakani T. M., Schwaneberg U., B？ker A. Nano-thin walled micro-compartments from transmembrane protein-polymer conjugates. Soft Matter. 2017, 13(15):2866-2875.
7. Charan H., Kinzel J., Glebe U., Anand D., Garakani T. M., Zhu L., Bocola M., Schwaneberg U., B？ker A. Grafting PNIPAAm from β-barrel shaped transmembrane nanopores. Biomaterials. 2016;107:115-23.
8. Cheng F.*, Zhu L.*, Schwaneberg U. Directed evolution 2.0: improving and deciphering enzyme properties. Chemical Communication, 2015, 51(48), 9760-9772. （共同第一作者）
9. Cheng F., Kardashliev T., Pitzler C., Shehzad A, Lue H., Bernhagen J, Zhu L.*, Schwaneberg U.* A competitive flow cytometry screening system for arginine-metabolizing enzyme in cancer treatment. ACS Synthetic Biology, 2015, 4(7):768-775. （共同通訊作者）
10. Machedjoua J., Fulton A., Zhu L., Ankera C., Bocola M., Jaeger K. and Schwaneberg U. Towards understanding of directed evolution: ＞52% amino acid positions contributed to ionic liquid resistance of Bacillus subtilis lipase A (BSLA). ChemBioChem, 2015, 16(6), 937-945.
11. Fulton A., Machedjoua J., Skoczinski P., Wilhelm S., Zhu L., Schwaneberg U. and Jaeger K. Exploring the protein stability landscape: Bacillus subtilis lipase A as a model for detergent tolerance. ChemBioChem, 2015, 16(6):930-6.
12. Zhu L., Cheng F., Piatkowski V. and Schwaneberg U. Protein engineering of PpADI for improved thermostability. ChemBioChem. 2014, 15(2), 276-83.
13. Cheng F., Zhu L., Lue H., Bernhagen J, Schwaneberg U. Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas. Applied Microbiology and Biotechnology, 2014, 99(3), 1237-1247. （共同通訊作者）
14. Rijn P., Tutus M., Kathrein C., Zhu L., Wessling M., Schwaneberg U., and B？ker A. Challenges and Advances in the Field of Self-Assembled Membranes, Chemical Society Reviews. 2013, 42(16):6578-6592.
15. Liu H., Zhu L., Bocola M., Chen N., Spiess A. C. and Schwaneberg U. Directed laccase evolution for improved ionic liquid resistance. Green Chemistry, 2013, 15, 1348-1355.
16. Philippart F., Arlt M., Gotzen S., Tenne S. J., Bocola M., Chen H. H., Zhu L., Schwaneberg U. and Okuda J. A hybrid ring-opening metathesis polymerization catalyst based on engineered ？-barrel protein FhuA. Chemistry a Euopean Journal. 2013, 19(41), 13865–13871.
17. Ni Y., Liu Y., Schwaneberg U., Zhu L., Li N., Li L., Sun Z. Rapid evolution of arginine deiminase for improved anti-tumor activity. Applied Microbiology Biotechnology. 2011, 90(1):193-201.
18. Zhu L., Rajni V., Roccatano D., Ni Y., Sun Z., and Schwaneberg U. A potential antitumor drug (arginine deiminase) reengineered for efficient operation under physiological conditions. ChemBioChem. 2010, 11(16):2294-301.
19. Zhu L., Tee K., Roccatano D., Sonmez B, Ni Y., Sun Z., and Schwaneberg U. Directed evolution of an antitumor drug (arginine deiminase PpADI) for increased activity at physiological pH. ChemBioChem. 2010, 11, 691-697.
20. Ni Y., Li Z., Sun Z., Zheng P., Liu Y. Zhu L., Schwaneberg U. Expression of arginine deiminase from Pseudomonas plecoglossicida CGMCC2039 in Escherichia coli and its anti-tumor activity. Current Microbiology. 2009, 58(6):593-8.
21. Liu Y., Zheng P, Sun Z., Ni Y., Dong J. and Zhu L. Economical succinic acid production from cane molasses by Actinobacillus succinogenes. Bioresource Technology. 2008, 99(6): 1736-1742.
22. Zhao L., Sun Z., Zheng P., Zhu L. Biotransformation of isoeugenol to vanillin by a novel strain, Bacillus fusiformis. Biotechnology Letters. 2005, 27, 1505-1509.
2、專著
Zhu L., Arlt M., Liu H., Schwaneberg U. Chapter 3: Channel protein FhuA as a promising biomolecular scaffold for bioconjugates. Bio-Synthetic Hybrid Materials and Bionanoparticles: A Biological Chemical Approach Towards Material Science. Royal Society of Chemistry,ISBN 9781849738224,2015.
3、專利
[1] Schwaneberg U., Zhu L. Directed evolution of arginine deiminase for increased activity at physiological pH, 德國，EP2295560A1 （WO 2011029696 A1），2011-03-17。
[2] 劉宇鵬, 孫志浩, 朱蕾蕾, 鄭璞。一種微生物發酵生產丁二酸的菌種和方法，中國， CN 100432215 C，2008-11-12。
科研項目
中國科學院重點部署項目子課題
中國科學院STS項目子課題
中國科學院-諾和諾德項目
