基本信息
學 歷: 博士
通訊地址: 廣州蘿崗區科學城開源大道190號
簡歷
1987-1993 加拿大McMaster大學生物系遺傳學博士
2001-2003 生物晶片北京國家工程中心,首席科學家
1999-2001 美國GCG生物信息公司,項目經理
1997-1999 美國強生Scios製藥公司生物信息部,研究員
1997-1997 美國Quest Diagnostics醫療診斷公司研發部,研究員
1994-1997 美國芝加哥大學生態與進化系,博士後
研究領域
1、人類重大疾病分子診斷新技術的研究;
2、獸藥殘留,
生物毒素和重金屬等食品安全和環境污染檢測技術的研究;
3、幹細胞治療的臨床前研究及臨床套用技術研究。
代表論著
l Fang Z, Wu W, Lu X, Zeng L. Lateral flow biosensor for DNA extraction-free detection of salmonella based on aptamer mediated strand displacement amplification. Biosens Bioelectron.
l Jie Liu, Lingbo Chen, Puchang Lie, Boying Dun and Lingwen Zeng*A universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification. Chem. Comm.
l Junhua Chen, Xuemeng Zhou and Lingwen Zeng. Enzyme-free strip biosensor for amplified detection of Pb2+ based on a catalytic DNA circuit .Chem. Comm.
l Zhiyuan Fang, Baishan Jiang, Wei Wu, Zhicheng Xiang, Chuanyan Ouyang,
Tulong Huang, Junhua Chen and Lingwen Zeng*ELISA detection of semicarbazide based on a fast sample pretreatment method†.Chem. Comm.
l Junhua Chen, Lingwen Zeng.Enzyme-amplified electronic logic gates based on split/intact aptamers. Biosensors and Bioelectronics
l Junhua Chen, Zhiyuan Fang, Puchang Lie, and Lingwen Zeng .Computational lateral flow biosensor for proteins and small molecules: A new class of strip logic gates. Anal. Chem
l Zhuo Xiao, Puchang Lie, Zhiyuan Fang, Luxin Yu, Junhua Chen, Jie Liu, Chenchen Ge, Xuemeng Zhou and Lingwen Zeng. A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction. Chem. Comm.
l Puchang Lie, Jie Liu, Zhiyuan Fang, Boying Dun and Lingwen Zeng. A lateral flow biosensor for detection of nucleic acids with high sensitivity and selectivity. Chem. Comm.
l Zhiyuan Fang, Chenchen Ge, Wenjuan Zhang, Puchang Lie, Lingwen Zeng. A lateral flow biosensor for rapid detection of DNA-binding protein c-jun. Biosensors and Bioelectronics,
l Jiekai Chen, Jing Liu, Jiaqi Yang, You Chen, Jing Chen, Su Ni, Hong Song, Lingwen Zeng, Ke Ding,Duanqing Pei. BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Research
l Tao Wang, Keshi Chen, Xiaoming Zeng, Jianguo Yang, Yun Wu, Xi Shi, Baoming Qin, Lingwen Zeng, Miguel Angel Esteban, Guangjin Pan and Duanqing Pei. The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner. Cell Stem Cell
l Zhiyuan Fang, Jing Huang, Puchang Lie, Zhuo Xiao, Chuanyan Ouyang, Qing Wu, Yixing Wu, Guodong Liu and Lingwen Zeng Lateral flow nucleic acid biosensor for Cu2+ detection in aqueous solution with high sensitivity and selectivity Chem. Comm
l Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B, Xu J, Li W, Yang J, Gan Y, Qin D,Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA, Pei D. 2010. A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts. Cell Stem Cell.
l Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell.
l Mao X, Xu H, Zeng Q,Zeng L, Liu G. Molecular beacon-functionalized gold nanoparticles as probes in dry-reagent strip biosensor for DNA analysis. Chem Comm.
l Liu G, Mao X, Phillips JA, Xu H, Tan W, Zeng L. Aptamer-Nanoparticle Strip Biosensor for Sensitive Detection of Cancer Cells. Anal Chem
l Mao X, Ma Y, Zhang A, Zhang L,Zeng L, Liu G.. Disposable nucleic acid biosensors based on gold nanoparticle probes and lateral flow strip. Anal Chem.