於燁，男，1977年11月生，博士，研究員，博士生導師。
2015年4月，入選2015年度“長江學者獎勵計畫”青年學者名單。
基本介紹
- 中文名：於燁
- 出生日期：1977年11月
- 畢業院校：蘭州大學
- 職稱：研究員
人物經歷,研究方向,主要貢獻,獲獎記錄,
人物經歷
2006年畢業於蘭州大學生命科學學院，多肽生物化學與藥物化學研究方向，獲理學博士學位。2006-2010年，在中科院上海生命科學研究院神經科學研究所做博士後，離子通道結構與功能研究方向；2011年加入上海交通大學醫學院研究團隊，任醫學科學研究院“蛋白質結構與功能研究組”組長。
研究方向
近年來一直從事蛋白質/多肽的結構和功能研究，擅長利用化學生物學、生物物理、分子藥理、分子生物學、計算生物學等多學科交叉的技術研究蛋白的結構與功能的關係及其相關的分子發現，取得了一系列較為重要的成果。
現階段的研究方向是具有重要醫學價值蛋白質的結構功能和活性分子發現研究，其中包括：1）膜受體激活過程中的動態變構機制與關鍵結構域鑑定；2）膜受體內源性調控分子的發現與生理病理功能研究；3）基於受體蛋白三維結構的藥物設計；4). 具有重要藥用價值的毒素蛋白靶受體的發現與藥物設計。主要採用化學生物學、生物物理、分子藥理、分子生物學、計算生物學等多學科交叉的技術研究這些蛋白的結構與功能的關係及其相關的分子發現。
主要貢獻
近年發表研究論文
1. Yang,Y*., Yu, Y.*, Cheng, J., Liu. Y,. Liu. D.S., Wang, J., Zhu, M.X., Wang,R., Xu, T.L. (2012). (Co-first author). Highly conserved salt bridge stabilizes a rigid signal patch at the extracellular loop critical for surface expression of acid-sensing ion channel. J Biol Chem, 287(18):14443-55，(IF2010: 5.328 )
2. Yang, H.Y., GaoZ.B., Yu, Y., Jiang H.L. et al. (2012). A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2 Potassium Channel. Biophys J.102:1815-1825，(IF2010: 4.218)
3. Yu, Y., Li, W.G.,Chen, Z., Jiang, H.L., Xu, T.L. (2011). Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channel. J Biol Chem, 286(28):24996-5006. (IF2010: 5.328 )
4. Li, W.G.*; Yu, Y.*，Huang，C.;Cao, H.;Xu, T.L. (2011).(*Co first author). Nonproton Ligand Sensing Domain Is Required for Paradoxical Stimulation of Acid-sensing Ion Channel 3 (ASIC3) Channels by Amiloride. J Biol Chem. 286(49):42635-46. (IF2010: 5.328 )
5. Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G, Wan Q, Feng H.(2011). Role of Acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Ann Surg.254(2): 353-62.(IF2010: 7.474).
6. Duan, B.;Wang, Y.Z.,Yang, T.,Chu, X.P.;Yu, Y., Xu ,T.L.(2011). Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis. J Neurosci. 31: 2011-12.(IF2010: 7.474).
7. Yu, Y., Chen. Z., Li. W.G. et al. (2010). A non-proton ligand sensor of acid-sensing ion channels. Neuron 68(1):61-72，(IF2010: 14.027).
* Commented in “Small molecule ion channel match making: a natural fit for new ASIC ligands”, Bagriantsev SN and Minor DL Jr. Neuron. 68(1):1-3
8. Li, W.G.*, Yu, Y.*; Zhang, Z.D.;Cao, H.;Xu, T.L. (2010).(*Co-first author).ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain. Mol Pain.86 (1):88-99 (IF2010: 4.148).
9. Yang, H.Y.*, Yu, Y.* Hua-liang Jiang, et al. (2009). (*Co-first author). Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. PLoS Biol. Jul;7(7) ):e1000151. (IF2010: 12.469).
10. Yang, H.Y.*, Yu, Y.*, Hua-liang Jiang, et al. (2009). (*Co-first author). Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation. Cell Res. 19(8):1035-7. (IF2010: 9.471).
11. Wang, C. L. Yao, J.L., Yu, Y., et al. (2008). Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 16(12):6415-22 (IF2010: 2.978).
12. Wang CL, Wang X, Yu Y, Cui Y, Liu HM, Lai LH, Guo C, Liu J, Wang R(2008). Type 1 diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility. Neuropeptides.42(1):69-77. (IF2010: 2.464).
13. Yu, Y., X. Shao, et al. (2007). Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C-terminus. ChemMedChem 2(3): 309-17. (IF2010: 3.306).
14. Yu, Y., X. Shao, et al. (2007). In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring. Peptides ;28(4):859-70.(IF2010: 2.654).
15. Yu, Y., Y. Cui, et al. (2007). In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for mu-opioid receptors, on mouse colonic motility. Biochem Pharmacol 73(9):1384-93. (IF2010: 4.889).
16. Wang, C.L*.,Yu.Y*, et al. (2007) (*Co-first author) Cardiovascular responses to intrathecal administration of endomorphins in anesthetized rats. Peptides 28(4):871-7.(IF2010: 2.654).
17. Wang, W., Yu, Y., et al. (2007). Modulation of acid-sensing ion channels by Cu2+ in cultured hypothalamic neurons of the rat. Neuroscience 145(2):631-641.
18. Yu, Y., C. L. Wang, et al. (2006). Cterminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats. Peptides 27(1): 136-43.(IF2010: 2.654).
19. Yu, Y., Y. Cui, et al. (2006). Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus. Peptides 27(7): 1846-51. (IF2010: 2.654).
20. Yu, Y., X. Wang, et al. (2006). Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats. Peptides 27(11): 2770-7. (IF2010: 2.654).
21. Fan, Y. Z., H. Chang, Yu, Y., et al. (2006). Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines. Peptides 27(9): 2165-73. (IF2010: 2.654).
22. Fan, Y. Z., H. Chang, Yu, Y., et al. (2006). Thymopentin (TP5), an immunomo- dulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta 1763(10): 1059-66.(IF2010: 4.374).
23. Liu, H. M., X. F. Liu, Yao, J. L. Wang, C.L, Yu, Y., et al. (2006). Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1. J Pharmacol Exp Ther 319(1): 308-16. (IF2010: 4.093).
24. Liu, J*, Yu. Y*, et al. (2005). (*Cofirst author) Cardiovascular effects of endomorphins in alloxan-induced diabetic rats. Peptides 26(4): 607-14. (IF2010: 2.654).
25. Xu, P. H., Cheng, Q., Li, H. F., Yu, Y., et al.(2005) The relaxant effect of dobutamine on porcine coronary arterial ring segments. Pharmazie. 60(5):375-7. (IF2010: 0.812).
3. Yu, Y., Li, W.G.,Chen, Z., Jiang, H.L., Xu, T.L. (2011). Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channel. J Biol Chem, 286(28):24996-5006. (IF2010: 5.328 )
4. Li, W.G.*; Yu, Y.*，Huang，C.;Cao, H.;Xu, T.L. (2011).(*Co first author). Nonproton Ligand Sensing Domain Is Required for Paradoxical Stimulation of Acid-sensing Ion Channel 3 (ASIC3) Channels by Amiloride. J Biol Chem. 286(49):42635-46. (IF2010: 5.328 )
5. Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G, Wan Q, Feng H.(2011). Role of Acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Ann Surg.254(2): 353-62.(IF2010: 7.474).
6. Duan, B.;Wang, Y.Z.,Yang, T.,Chu, X.P.;Yu, Y., Xu ,T.L.(2011). Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis. J Neurosci. 31: 2011-12.(IF2010: 7.474).
7. Yu, Y., Chen. Z., Li. W.G. et al. (2010). A non-proton ligand sensor of acid-sensing ion channels. Neuron 68(1):61-72，(IF2010: 14.027).
* Commented in “Small molecule ion channel match making: a natural fit for new ASIC ligands”, Bagriantsev SN and Minor DL Jr. Neuron. 68(1):1-3
8. Li, W.G.*, Yu, Y.*; Zhang, Z.D.;Cao, H.;Xu, T.L. (2010).(*Co-first author).ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain. Mol Pain.86 (1):88-99 (IF2010: 4.148).
9. Yang, H.Y.*, Yu, Y.* Hua-liang Jiang, et al. (2009). (*Co-first author). Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. PLoS Biol. Jul;7(7) ):e1000151. (IF2010: 12.469).
10. Yang, H.Y.*, Yu, Y.*, Hua-liang Jiang, et al. (2009). (*Co-first author). Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation. Cell Res. 19(8):1035-7. (IF2010: 9.471).
11. Wang, C. L. Yao, J.L., Yu, Y., et al. (2008). Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 16(12):6415-22 (IF2010: 2.978).
12. Wang CL, Wang X, Yu Y, Cui Y, Liu HM, Lai LH, Guo C, Liu J, Wang R(2008). Type 1 diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility. Neuropeptides.42(1):69-77. (IF2010: 2.464).
13. Yu, Y., X. Shao, et al. (2007). Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C-terminus. ChemMedChem 2(3): 309-17. (IF2010: 3.306).
14. Yu, Y., X. Shao, et al. (2007). In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring. Peptides ;28(4):859-70.(IF2010: 2.654).
15. Yu, Y., Y. Cui, et al. (2007). In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for mu-opioid receptors, on mouse colonic motility. Biochem Pharmacol 73(9):1384-93. (IF2010: 4.889).
16. Wang, C.L*.,Yu.Y*, et al. (2007) (*Co-first author) Cardiovascular responses to intrathecal administration of endomorphins in anesthetized rats. Peptides 28(4):871-7.(IF2010: 2.654).
17. Wang, W., Yu, Y., et al. (2007). Modulation of acid-sensing ion channels by Cu2+ in cultured hypothalamic neurons of the rat. Neuroscience 145(2):631-641.
18. Yu, Y., C. L. Wang, et al. (2006). Cterminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats. Peptides 27(1): 136-43.(IF2010: 2.654).
19. Yu, Y., Y. Cui, et al. (2006). Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus. Peptides 27(7): 1846-51. (IF2010: 2.654).
20. Yu, Y., X. Wang, et al. (2006). Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats. Peptides 27(11): 2770-7. (IF2010: 2.654).
21. Fan, Y. Z., H. Chang, Yu, Y., et al. (2006). Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines. Peptides 27(9): 2165-73. (IF2010: 2.654).
22. Fan, Y. Z., H. Chang, Yu, Y., et al. (2006). Thymopentin (TP5), an immunomo- dulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta 1763(10): 1059-66.(IF2010: 4.374).
23. Liu, H. M., X. F. Liu, Yao, J. L. Wang, C.L, Yu, Y., et al. (2006). Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1. J Pharmacol Exp Ther 319(1): 308-16. (IF2010: 4.093).
24. Liu, J*, Yu. Y*, et al. (2005). (*Cofirst author) Cardiovascular effects of endomorphins in alloxan-induced diabetic rats. Peptides 26(4): 607-14. (IF2010: 2.654).
25. Xu, P. H., Cheng, Q., Li, H. F., Yu, Y., et al.(2005) The relaxant effect of dobutamine on porcine coronary arterial ring segments. Pharmazie. 60(5):375-7. (IF2010: 0.812).
近年所獲國家發明專利
1. Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-1 (No. 200410073159.2.).
2. Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-2 (No. 200710147468.3.).
3. Wang, R., Fan, Y.Z., Yu, Y., Chang, H. A new usage of polyhexose isolated from pumpkin (200710017285X.)。
2. Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-2 (No. 200710147468.3.).
3. Wang, R., Fan, Y.Z., Yu, Y., Chang, H. A new usage of polyhexose isolated from pumpkin (200710017285X.)。
獲獎記錄
近年來，已有26篇SCI論文在Neuron, PLoS Biol., J Biol Chem, Cell Res., J Neurosci., Ann Surg. Mol Pain, Biochem Pharm., ChemMedChem, Peptides, Neurosci., BBA Mol. Res., J Pharmacol Exp. Ther 等國際知名學術雜誌上發表，其中第一/並列第一作者SCI論文共15篇，篇均影響因子>5（IF2010）；論文多次被國內外同行在Nature, Neuron，Chem Rev, J Neurosci, J Biol Chem等知名雜誌上正面引用。主持並完成國家自然科學基金委青年科學基金項目、“中國博士後科學基金”項目、“中國科學院王寬誠基金”資助項目、中國科學院上海生命科學研究院優秀青年人才領域前沿項目各1項。曾獲“香港求是基金會”研究生獎，中國博士後科學基金一等獎，甘肅省科學技術發明獎一等獎；中國科學院上海生命科學研究院優秀青年人才，“Sanofi-Aventis-SIBS”優秀青年人才，基金委首批"優秀青年"獲得者。
