《新型納米材料在生物樣品富集和分離中的套用》是白玉為項目負責人，北京大學為依託單位的面上項目。
基本介紹
- 中文名：新型納米材料在生物樣品富集和分離中的套用
- 項目類別 ：面上項目
- 項目負責人：白玉
- 依託單位 ：北京大學
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | The Principles and Applications of An Ambient Ionization Method-Direct Analysis in Real Time (DART) | 期刊論文 | Huo Feifeng|Zhou Zhigui|Bai Yu|Liu Huwei| |
2 | Recent advances in applications of nanomaterials for sample preparation | 期刊論文 | Qi Xiaoyue|Li Xianjiang|Bai Yu|Liu Huwei| |
3 | Just dip it: online coupling of "Dip-it'' polymer monolith microextraction with plasma assisted laser desorption ionization mass spectrometry | 期刊論文 | Wang, Xin|Li, Xianjiang|Bai, Yu|Liu, Huwei| |
4 | GdF3 as a promising phosphopeptide affinity probe and dephospho-labelling medium: experiments and theoretical explanation | 期刊論文 | Li Ze|Bai Yu|Xiao Yun-Long|Liu Hu-Wei| |
5 | Novel nanomaterials used for sample preparation for protein analysis | 期刊論文 | Xu, Linnan|Li, Ze|Bai, Yu|Liu, Huwei| |
6 | A DNA-templated synthesis of encoded small molecules by DNA self-assembly | 期刊論文 | Chen, Zitian|Huang, Yanyi|Bai, Yu|Li, Xiaoyu| |
7 | Guanidyl-functionalized graphene as a bifunctional adsorbent for selective enrichment of phosphopeptides | 期刊論文 | Li, Li-Ping|Jin, Liang|Bai, Yu|Liu, Hu-Wei| |
8 | Thin Layer Chromatography/Plasma Assisted Multiwavelength Laser Desorption Ionization Mass Spectrometry for Facile Separation and Selective Identification of Low Molecular Weight Compounds | 期刊論文 | Yang jianwang|Zhang Wei|Bai Yu|Liu Huwei| |
9 | Template-free synthesis of uniform mesoporous SnO2 nanospheres for efficient phosphopeptide enrichment | 期刊論文 | Bai, Yu|Nie, Zongxiu|Liu, Huwei|Qi, Limin| |
10 | Novel nanomaterials used for sample preparation for protein analysis | 期刊論文 | Xu, Linnan|Li, Ze|Bai, Yu|Liu, Huwei| |
11 | SnO2–ZnSn(OH)6: a novel binary affinity probe for global phosphopeptide detection | 期刊論文 | Sun Lingdong|Nie Zongxiu|Bai Yu|Liu Huwei| |
12 | Applications of ambient mass spectrometry in high-throughput screening | 期刊論文 | Yang, Jian-Wang|Chang, Cui-Lan|Bai, Yu|Liu, Hu-Wei| |
13 | A newderivatizationapproachfortherapidandsensitiveanalysis of brassinosteroidsbyusingultrahighperformanceliquid chromatography-electrosprayionizationtriplequadrupole mass spectrometry | 期刊論文 | Bai Yu|Zhang Wei|Yuan Hancheng|Liu Huwei| |
14 | Automated and sensitive analysis of 28-epihomobrassinolide inArabidopsis thaliana by on-line polymer monolith microextractioncoupled to liquid chromatography–mass spectrometry | 期刊論文 | Cuilan Chang|Yu Bai|Yuqi Feng|Huwei Liu| |
15 | A lithium-rich composite metal oxide used as a SALDI-MS matrix for the determination of small biomolecules | 期刊論文 | Xin Y.-L.|Bai Y.|Zhou H.-H.|Liu H.-W.| |
16 | A DNA-templated synthesis of encoded small molecules by DNA self-assembly | 期刊論文 | Chen Z.|Huang Y.|Bai Y.|Li X.| |
17 | Direct analysis in real time mass spectrometry combined with single-drop liquid–liquid–liquid microextraction for the rapid analysis of multiple phytohormones in fruit juice | 期刊論文 | Yu Bai|Jialing Zhang|Yu Bai|Huwei Liu| |
18 | Lipidomic analysis of p-chlorophenylalanine-treated mice using continuous-flow two-dimensional liquid chromatography/quadrupole time-of-flight mass spectrometry | 期刊論文 | Li, Min|Tian, Yonglu|Bai, Yu|Liu, Huwei| |
19 | Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency | 期刊論文 | Liu, Yi|Chang, Cuilan|Bai, Yu|Liu, Huwei| |
20 | Hydrazide functionalizedmonodispersed silica microsphere: a novel probe with tunable selectivity forversatile enrichment of phosphopeptides with different numbers ofphosphorylation sites in MS analysis | 期刊論文 | Shen Sensen|Li Liping|Bai Yu|Liu Huwei| |
21 | GdF3 as a promising phosphopeptide affinity probe and dephospho-labelling medium: experiments and theoretical explanation | 期刊論文 | Li, Ze|Bai, Yu|Xiao, Yun-Long|Liu, Hu-Wei| |
22 | Guanidyl-functionalized graphene as a bifunctional adsorbent for selective enrichment of phosphopeptides | 期刊論文 | Li L.-P.|Jin L.|Bai Y.|Liu H.-W.| |
23 | 實時直接分析質譜的原理與套用 | 期刊論文 | 霍飛鳳|周志貴|白玉|劉虎威| |
24 | Thin Layer Chromatography/Plasma Assisted Multiwavelength Laser Desorption Ionization Mass Spectrometry for Facile Separation and Selective Identification of Low Molecular Weight Compounds | 期刊論文 | Yang, Jianwang|Zhang, Wei|Bai, Yu|Liu, Huwei| |
項目摘要
蛋白組學領域的飛速發展依賴於分離技術和檢測技術的日新月異。由於蛋白組學中涉及到體系非常複雜的生物樣品，在分析檢測過程中往往需要準確有效的樣品預處理和預分離。現今各類特色的納米材料層出不窮、合成條件不斷改進的情況下，充分發揮其比表面積大、活性中心多等特性、尋找合適的納米新材料，以實現複雜臨床生物樣品以及具有重要生物學意義的小分子被分析物的高通量、高解析度和高靈敏度分離分析顯得尤為重要。本申請將氧化石墨烯、納米介孔材料、三維開放骨架材料等新型納米材料套用於多肽的特異性富集、蛋白質線上酶解除鹽集成裝置以及小分子的快速篩選當中，期望建立高通量、高靈敏的蛋白質樣品預處理新方法；並建立納米材料用於雷射DART-MS用於有生物學意義的小分子化合物的快速分析篩選新方法。
