基本介紹
- 中文名：徐沙
- 國籍：中國
- 畢業院校：江南大學生物工程學院
- 學位/學歷：博士
- 職業：教師
- 專業方向：微生物代謝工程
- 任職院校：江南大學生物工程學院
人物經歷,主講課程,發表論文,專利成果,科研項目,
人物經歷
2002.9 – 2006.6 南京農業大學食品科技學院 本科
2006.9 – 2011.6 江南大學生物工程學院 碩博連讀
2012.1–2012.2日本產業綜合研究所(AIST) 訪問學者
2013.11–2014.2 日本產業綜合研究所(AIST) 訪問學者
2016.8 – 2017.8 美國康奈爾大學 訪問學者
2011.8-2015.10 江南大學生物工程學院 校聘副教授
2015.10-至今 江南大學國家工程實驗室 副教授
主講課程
擔代謝途徑工程、發酵工程原理與技術課程。
發表論文
1.Sha Xu, Qin Wang, Weizhu Zeng, Youran Li, Guiyang Shi, Jingwen Zhou*. Construction of a heat-inducibleEscherichia coli strain for efficient de novo biosynthesis of L-tyrosine, Process Biochem, 2020, 92: 85-92.
2. Sha Xu, Yu Zhang, Youran Li, Xiaole Xia, Jingwen Zhou*, Guiyang Shi*. Production of L-tyrosine usingtyrosine phenol-lyase by whole cell biotransformation approach. Enzyme Microb. Tech. 2019, 131, 109430
3. Yongkun Lv, Sha Xu, Yunbin Lyu, Shenghu Zhou, Guocheng Du, Jian Chen, Jingwen Zhou*. Engineeringenzymatic cascades for the efficient biotransformation of eugenol and taxifolin to silybin and isosilybin. GreenChem. 2019, 21(7):1660-1667.
4. Wang Panpan, Zeng Weizhu, Xu Sha, Du Guocheng, Zhou Jingwen*, Chen Jian*. Current challenges facing onestep production of l-ascorbic acid. Biotechnol Adv. 2018, 36(7): 1882-1899.
5. Huijie Zhang, Ting Yan, Sha Xu, Shini Feng, Dandi Huang, Morihisa Fujita, Xiaodong Gao*. Graphene oxidechitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides. Mater SciEng C Mater Biol Appl. 2017, 73:144-151.
6. Weizhu Zeng, Hailin Zhang, Sha Xu, Fang Fang, Jingwen Zhou*. Biosynthesis of keto acids by fed-batch cultureof Yarrowia lipolytica WSH-Z06. Bioresour Technol. 2017, 243:1037-1043.
7. Sha Xu, Geyuan Zhang, Huijie Zhang, Toshihiko Kitajima, Hideki Nakanishi, Xiaodong Gao*. Effects of Rho1, asmall GTPase on the production of recombinant glycoproteins in Saccharomyces cerevisiae. Microb Cell Fact. 2016,15 (1):179.
8. Shengtao Li, Ning Wang, Sha Xu, Jian Yin, Hideki Nakanishi, Neta Dean, Xiaodong Gao*. Quantitative study ofyeast Alg1 beta-1,4 mannosyltransferase activity, a key enzyme involved in protein N-glycosylation. BiochimBiophys Acta 1861. 2016 (1 Pt A):2934-2941.
9. Yu Deng, Mingxue Sun, Sha Xu, Jingwen Zhou*. Enhanced (S)-linalool production by fusion expression offarnesyl diphosphate synthase and linalool synthase in Saccharomyces cerevisiae. J Appl Microbiol. 2016,doi:10.1111/jam.13105.
10. Jingwen Zhou*, Kui Wang, Sha Xu, Junjun Wu, Peiran Liu, Guocheng Du, Jianghua Li*, Jian Chen.Identification of membrane proteins associated with phenylpropanoids tolerance and transport in Escherichia coliBL21. J Proteomics. 2015, 113: 15-28.
11. Sha Xu, Xiaobei Wang, Guocheng Du, Jingwen Zhou*, Jian Chen. Enhanced production of L-sorbose from Dsorbitol by improving the mRNA abundance of sorbitol dehydrogenase in Gluconobacter oxydans WSH-003.Microb Cell Fact. 2014, 13:146.
12. Sha Xu, Yaqiong Guo, Guocheng Du, Jingwen Zhou*, Jian Chen. Self-cloning significantly enhances theproduction of catalase in Bacillus subtilis WSHDZ-01. Appl Biochem Biotechnol. 2014, 173(8): 2152-62.
13. Sha Xu, Zhengxiong Zhou, Zhaozhe Hua, Guocheng Du, Jingwen Zhou*, Jian Chen. Efficient transformation ofRhizopus delemar by electroporation of germinated spores. J Microbiol Meth. 2014. 103: 58-63.
14. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen* Arginine: a novel compatible solute to protect Candida glabrataagainst hyperosmotic stress. Proc Biochem. 2011, 44(6): 1230-1235.
15. Yi Qin, Liming Liu, Changhao Li, Sha Xu, and Jian Chen*. Accelerating glycolytic flux of Torulopsis glabrataCCTCC M202019 at high oxiodreduction potential created using potassium ferricyanide. Biotechnol Prog, 2010,26(6): 1551-1557.
16. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen*. Water-forming NADH oxidaseprotectsTorulopsisglabrataagainst hyperosmotic stress. Yeast. 2010, 27(4): 207-216.
17. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen*. Proline enhances Torulopsis glabrata growthduringhyperosmotic stress. Biotechnol Bioproc Eng. 2010, 15(2): 285-292.
18. 焦亭亭, 周景文, 徐沙*. 柚皮素合成關鍵基因表達水平對目標產物積累水平的量化影響. 生物工程學報.2019, 35(7): 1256-1265.
19. 董寧遠, 張閣元, 徐沙, 高曉冬*. 來源於胞麴黴的α-1,2-甘露糖苷酶在釀酒酵母Δalg3Δoch1Δmnn1菌株中的定位表達. 食品與發酵工業. 2016, 42 (6):1-6.
20. 張閣元, 徐沙, 高曉冬*, 中西秀樹. 釀酒酵母糖基化缺陷型菌株中ALG6基因的過量表達. 食品與發酵工業.2015, 41 (5):1-7.
21. 賀鐵凡, 徐沙, 張閣元, 中西秀樹, 高曉冬*. 重構釀酒酵母N-糖基化途徑生產人源化糖蛋白. 微生物學報.2014, 54 (5):509-516.
22. 徐沙, 中西秀樹, 高曉冬*. 糖蛋白藥物表達系統糖基化研究進展. 微生物學報. 2013, 53 (3):221-229
專利成果
1. 堵國成, 徐沙, 劉立明, 陳堅. 一種添加脯氨酸促進丙酮酸過量積累的方法. 公開號：101225410.
2. 陳堅, 徐沙, 劉立明, 堵國成. 一種提高光滑球擬酵母抵禦高滲透壓脅迫的方法. 公開號：101591670
科研項目
1. 國家自然基金青年項目“超糖基化缺陷型釀酒酵母生產人源化糖蛋白N-聚糖位點占有率定向調控” (21406087), 主持
2. 江南大學自主科研計畫項目基金“重組釀酒酵母產人促紅細胞生成素糖基化機制的研究”，(JUSRP211A25), 主持
3. 工業生物技術教育部重點實驗室開放課題“Alg1結構與膜結合性質的研究”(KLIB-KF201106),
