徐佳佳，男，博士，畢業於中國科學院上海生命科學研究院，現任職於南方醫科大學，副教授，碩士生導師。
基本介紹
- 中文名：徐佳佳
- 國籍：中國
- 民族：漢族
- 畢業院校：中國科學院上海生命科學研究院
- 學位/學歷：博士
- 職業：教師
- 任職院校：南方醫科大學
- 職稱：副教授
人物經歷,研究方向,代表性論文,獲獎記錄,
人物經歷
2017年博士畢業於中國科學院上海生命科學研究院，師從戴尅戎院士。2017-2021年就職於美國約翰霍普金斯大學（Johns Hopkins University）醫學院從事骨科基礎研究，聚焦於幹細胞分化和組織再生方向。2022年以南方醫科大學第四層次人才引進，副教授，碩士生導師。主持國家級項目2項、廣東省基礎與套用基礎基金2項、廣州市基礎與套用基礎基金1項等。發表SCI文章43篇，其中第一作者文章10篇，包括Science Advances, Cell Death & Differentiation, Bone Research，Theranostics和eLife等，特邀綜述4篇，申請專利2項。引用近1500次，h指數20。國際會議特邀報告7次，獲ASBMR和ORS青年研究員獎。
研究方向
1. 間充質幹細胞分化調控機制研究；
2. 幹細胞介導的組織再生修復；
3. 骨代謝及骨骼退行性疾病防治。
代表性論文
1. Xu, J.*, Li, Z.*, Tower, R. J.*, Negri, S., Wang, Y., Meyers, C. A., Sono, T., Qin, Q., Lu, A., Xing, X., McCarthy, E. F., Clemens, T. L., & James, A. W. (2022). NGF-p75 signaling coordinates skeletal cell migration during bone repair. Science Advances, 8(11), eabl5716. (IF: 14.957)
2. Xu, J.*, Wang, Y.*, Li, Z., Tian, Y., Li, Z., Lu, A., Hsu, C. Y., Negri, S., Tang, C., Tower, R. J., Morris, C., & James, A. W. (2022). PDGFRα reporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair. Bone Research, 10(1), 7. (IF: 13.362)
3. Xu, J., Li, D., Hsu, C. Y., Tian, Y., Zhang, L., Wang, Y., Tower, R. J., Chang, L., Meyers, C. A., Gao, Y., Broderick, K., Morris, C., Hooper, J. E., Nimmagadda, S., Peault, B., & James, A. W. (2020). Comparison of skeletal and soft tissue pericytes identifies CXCR4 bone forming mural cells in human tissues. Bone Research, 8(1), 22. (IF: 13.362，被Nature Reviews Molecular Cell Biology綜述突出引用)
4. Xu, J., Wang, Y., Li, J., Zhang, X., Geng, Y., Huang, Y., Dai, K.#, & Zhang, X.# (2016). IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells. Cell Death Differ, 23(12), 1941-1951. (IF: 12.067)
5. Xu, J., Li, J., Hu, Y., Dai, K., Gan, Y., Zhao, J., Huang, M., & Zhang, X. (2020). IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders. Theranostics, 10(9), 3925-3938. (IF: 11.6)
6. Xu, J., Wang, Y., Hsu, C. Y., Gao, Y., Meyers, C. A., Chang, L., Zhang, L., Broderick, K., Ding, C., Peault, B., Witwer, K., & James, A. W. (2019). Human perivascular stem cell-derived extracellular vesicles mediate bone repair. eLife, 8. (IF: 8.713)
7. Xu, J., Liu, J., Gan, Y., Dai, K., Zhao, J., Huang, M., Huang, Y., Zhuang, Y., & Zhang, X. (2020). High-Dose TGF-beta1 Impairs Mesenchymal Stem Cell-Mediated Bone Regeneration via Bmp2 Inhibition. J Bone Miner Res, 35(1), 167-180. (IF: 6.39)
8. Xu, J.*, Wang, Y.*, Hsu, C. Y., Negri, S., Tower, R. J., Gao, Y., Tian, Y., Sono, T., Meyers, C. A., Hardy, W. R., Chang, L., Hu, S., Kahn, N., Broderick, K., Peault, B., & James, A. W. (2020). Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells. eLife, 9. (IF: 8.713)
9. Wang, Y.*, Xu, J.*, Meyers, C. A., Gao, Y., Tian, Y., Broderick, K., Peault, B., & James, A. W. (2020). PDGFRalpha marks distinct perivascular populations with different osteogenic potential within adipose tissue. Stem Cells, 38(2), 276-290. (IF: 5.845)
10. Xu, J.*, Wang, Y.*, Gomez-Salazar, M. A.*, Hsu, G. C., Negri, S., Li, Z., Hardy, W., Ding, L., Peault, B., & James, A. W. (2021). Bone-forming perivascular cells: Cellular heterogeneity and use for tissue repair. Stem Cells, 39(11), 1427-1434. (IF: 5.845)
11. Xu, J.*, Zhang, Z.*, Zhao, J., Meyers, C. A., Lee, S., Qin, Q., & James, A. W. (2022). Interaction between the nervous and skeletal systems. Front Cell Dev Biol, 10, 976736. (IF: 6.081)
12. Xu, J., Wang, Y., Hsu, C. Y., Negri, S., Presson, B., Peault, B., & James, A. W. (2020). Functional heterogeneity of perivascular precursor cells. Current Tissue Microenvironment Reports, 1, 183-186.
13. Meyers, C. A.*, Lee, S.*, Sono, T.*, Xu, J., Negri, S., Tian, Y., Wang, Y., Li, Z., Miller, S., Chang, L., Gao, Y., Minichiello, L., Clemens, T. L.#, & James, A. W.# (2020). A Neurotrophic Mechanism Directs Sensory Nerve Transit in Cranial Bone. Cell Rep, 31(8), 107696. (IF: 9.995)
14. Wang, Y., Venkatesh, A., Xu, J., Xu, M., Williams, J., Smallwood, P. M., James, A., & Nathans, J. (2022). The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development. Development, 149(9), dev200340. (IF: 6.862)
15. Zhao, J.*, Huang, M.*, Zhang, X., Xu, J., Hu, G., Zhao, X., Cui, P., & Zhang, X. (2019). MiR-146a Deletion Protects From Bone Loss in OVX Mice by Suppressing RANKL/OPG and M-CSF in Bone Microenvironment. J Bone Miner Res, 34(11), 2149-2161. (IF: 6.741)
16. Qi, R., Guo, R., Shen, M., Cao, X., Zhang, L., Xu, J., Yu, J., & Shi, X. (2010). Electrospun poly(lactic-co-glycolic acid)/halloysite nanotube composite nanofibers for drug encapsulation and sustained release. Journal of Materials Chemistry, 20(47), 10622-10629.
17. Lee, S.*, Hwang, C.*, Marini, S., Tower, R. J., Qin, Q., Negri, S., Pagani, C. A., Sun, Y., Stepien, D. M., Sorkin, M., Kubiak, C. A., Visser, N. D., Meyers, C. A., Wang, Y., Rasheed, H. A., Xu, J., Miller, S., Huber, A. K., Minichiello, L., Cederna, P. S., Kemp, S. W., Clemens, T. L., James, A. W.#, Levi, B. # (2021). NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma. Nature Communications, 12(1), 4939. (IF: 17.694)
18. Sorkin, M.*, Huber, A. K.*, Hwang, C., Carson, W. F. t., Menon, R., Li, J., Vasquez, K., Pagani, C., Patel, N., Li, S., Visser, N. D., Niknafs, Y., Loder, S., Scola, M., Nycz, D., Gallagher, K., McCauley, L. K., Xu, J., James, A. W., . . . Levi, B. (2020). Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nature Communications, 11(1), 722. (IF: 14.919)
獲獎記錄
2021 國際骨科研究學會（ORS）青年研究員獎
2021 國際骨科研究學會國際骨折修復分會（ORS ISFR）學生/實習生獎
2020 美國骨與礦物質研究協會（ASBMR）青年研究員獎
