張新新(西安交通大學教師)

張新新，西安交通大學副教授，碩士研究生導師，陝西省中醫藥優秀中青年科技骨幹人才。陝西省天然藥物學會委員，陝西省植物學會委員。Phytotherapy Research、Journal of Cleaner Production、Phytomedicine和Journal of Ethnopharmacology等雜誌審稿專家。

基本介紹

• 中文名：張新新
• 畢業院校：西北大學

人物簡介

張新新，男，醫學博士，副教授，碩士研究生導師。主要從事中藥和天然藥物活性成分研究工作抹希境，參與禁拳院本科生《提估滲天然藥物承乃拒少化學》和研究生《新藥發現與篩選》授課。抹設

教育經歷

2010.09-2015.07 西北白漿奔殼大學 中藥學 醫學博士

2006.09-2010.07 西北大學 生物技術 理學學士

工作經歷

2019.05-至今西安交通大學副教授

2017.11-2018.10 英國帝國理工學習危組院 訪問學者

2015.10-2019.04西安交通大學 講師

研究方向

中藥和天然藥物活性成分研究

學術成果

SCI學術論文

[1] Xinxin Zhang, Zhaowei Xue, Shangjun Zhu, Yuting Guo, Yan Zhang, Jianwei Dou, Jiye Zhang, Yoichiro Ito, Zengjun Guo. Diosgenin revealed potential effect against cerebral ischemia reperfusion through HIKESHI/HSP70/NF-κB anti-inflammatory axis. Phytomedicine, 2022, 153991.

[2]Zhaowei Xue, Zhen Cao, Ming Jin, Xinxin Zhang*, Xinrui Wang, Jianwei Dou, Yuhong Zhu, Yoichiro Ito, Zengjun Guo. New bitter substances from medicine food homologous Dioscorea zingiberensis yam and their potential functions. Food & Function, 2021, 12(18), 8314-8325.

[3]Xinxin Zhang, Xingbin Wang, Zhaowei Xue, Guanqun Zhan, YoichiroIto, Zengjun Guo. Prevention properties on cerebral ischemia reperfusion ofmedicine food homologous Dioscoreayam-derived diosgenin based on mediation of potential targets. Food Chemistry,2021, 345: 128672-128684.

[4] Muhammad Khurm, Xingbin Wang, Hui Zhang, Sajid Nawaz Hussain, Muhammad Naeem Qaisar, Khezar Hayat, Fatima Saqib, Xinxin Zhang*, Guanqun Zhan, Zengjun Guo. The genus Cassia L.: Ethnopharmacological and phytochemical overview. Phytotherapy Research, 2020, 1-50.

[5] Xinxin Zhang, Xingbin Wang,Muhammad Khurm, Guanqun Zhan, Hui Zhang,Yoichiro Ito, Zengjun Guo. Alterations of brain quantitative proteomicsprofiling revealed the molecular mechanisms of diosgenin against cerebralischemia reperfusion effects. Journal of Proteome Research, 2020, 19(3): 1154-1168.

[6] Xinxin Zhang, Ming Jin, Nigatu Tadesse, Guanqun Zhan, Hui Zhang,Jun Dang, Sicen Wang, Zengjun Guo, Yoichiro Ito.Methods to treat the industrial wastewaterin diosgenin enterprises produced from Diosoreazingiberensis C. H. Wright. Journal of Cleaner Production. 2018, 186: 34-44.

[7] Xinxin Zhang, Guanqun Zhan, Ming Jin, Hui Zhang, Jun Dang, YanZhang, Zengjun Guo, Yoichiro Ito. Botany, traditional use, phytochemistry, pharmacology,quality control, and authentication of RadixGentianae Macrophyllae-A traditional medicine: A review. Phytomedicine,2018, 46: 142-163.

[8] Xinxin Zhang, Ming Jin, Nigatu Tadesse, Jun Dang, Tao Zhou, HuiZhang, Sicen Wang, Zengjun Guo, Yoichiro Ito. Dioscorea zingiberensis C. H. Wright: Anoverview on its Traditional Use, Phytochemistry, Pharmacology, Clinical Applications,Quality Control, and Toxicity.Journal of Ethnopharmacology, 2018, 220: 283-293.

[9] Xinxin Zhang, Ming Jin, NigatuTadesse, Liang Xian, Hui Zhang, Sicen Wang, Jun Dang, Yan Zhang, Zengjun Guo,Yoichiro Ito. Safetyinvestigation on total steroid saponins extracts from Dioscorea zingiberensis C.H. Wright: Sub-acute and chronic toxicitystudies on dogs. Regulatory Toxicology and Pharmacology, 2017, 91: 58-67.

[10] Xinxin Zhang, Dandan Li, Xuanji Xue,Yan Zhang, Jie Zhang, Chen Huang, Zengjun Guo, Nigatu Tadesse. Firsttotal synthesis of a novel amide alkaloid derived from Aconitum taipeicum andits anticancer activity. Natural Product Research, 2017, (9): 1-5.

[11] Xinxin Zhang, Xuanji Xue, Jing Zhao,Zengjun Guo, Yoichiro Ito, Wenji Sun. Quantitativedetermination of gracillin by HPLC-MS/MS after oral administration and itsapplication to a pharmacokinetic study. Steroids,2016, 113: 78-86.

[12] Xinxin Zhang, Xuanji Xue, Liang Xian,Zengjun Guo, Yoichiro Ito, Wenji Sun.Potential neuroprotection of protodioscin againstcerebral ischemia-reperfusion injury in rats through intervening inflammationand apoptosis. Steroids, 2016, 113: 52-63.

[13] XinxinZhang, Zengjun Guo,Jing Li, Yoichiro Ito, Wenji Sun. A new quantitation method of protodioscin byHPLC-ESI-MS/MS in rat plasma and its application to the pharmacokinetic study.Steroids, 2016, 106: 62-69.

[14] XinxinZhang,Xuanji Xue, Jing Zhao, Chunxiang Qian, Zengjun Guo, Yoichiro Ito, Wenji Sun. Diosgeninattenuates the brain injury induced by transient focal cerebralischemia-reperfusion in rats. Steroids, 2016, 113: 103-112.

[15] XinxinZhang, Jing Li,Yoichiro Ito, Wenji Sun. Simultaneous quantification of five steroidsaponins from Dioscorea zingiberensis C.H. Wright in rat plasma by HPLC-MS/MS and its application to thepharmacokinetic studies. Steroids, 2015, 93, 16-24.

[16] XinxinZhang, Jinru Liang,Jianli Liu, Ye Zhao, Juan Gao, Wenji Sun, Yoichiro Ito. Qualitycontrol and identification of steroid saponins from Dioscorea zingiberensis C.H.Wright by fingerprint with HPLC-ELSDand HPLC-ESI-Quadrupole/Time-of-fight tandem mass spectrometry. Journalof Pharmaceutical and Biomedical Analysis, 2014, 91: 46-59.

[17] XinxinZhang, Yoichiro Ito,Jinru Liang, Jianli Liu, Jiao He, Wenji Sun. Therapeutic effects of totalsteroid saponin extracts from the rhizome of Dioscorea zingiberensis C.H.Wright in Freund’s complete adjuvantinduced arthritis in rats. International Immunopharmacology,2014, 23, 407-416.

[18] XinxinZhang, Lin Chen, XuanDang, Jianli Liu, Yoichiro Ito, Wenji Sun. Neuroprotective effectsof total steroid saponins on cerebral ischemia injuries in an animal model offocal ischemia/reperfusion. Planta Medica,2014, 80: 637-644.

[19] XinxinZhang, Lin Chen, JianliLiu, Yoichiro Ito, Jiao He, Wenji Sun. Neuroprotection oftotal steroid saponins from Dioscoreazingiberensis against transient focal cerebral ischemia-reperfusion injuryin rats via its anti-inflammatory and anti-apoptotic effects. PlantaMedica, 2014, 80, 1597-1604.

[20]XinxinZhang, Yoichiro Ito, Jinru Liang, Qi Su, Yongmin Zhang,Jianli Liu, Wenji Sun. Preparative isolation and purification of fivesteroid saponins from Dioscoreazingiberensis C. H. Wright by counter-current chromatography coupled withevaporative light scattering detector. Journal of Pharmaceutical andBiomedical Analysis, 2013, 84: 117-123.

[21]XinxinZhang, Jianli Liu, Wenji Sun, Yoichiro Ito. Comparative Studieson Performance of CCC and Preparative RP-HPLC in Separation and Purification ofSteroid Saponins from DioscoreaZingiberensis C. H. Wright. Journal of Steroids & Hormonal Science,2015, 6(1): 1-9.

中文核心期刊

[1] 金明, 仙靚, 孫麗娜, 石碩, 張卉, 張新新, 郭增軍. 盾葉薯蕷中甾體皂苷的分離與結構鑑定. 西北藥學雜誌, 2017, (04): 395-399.

[2] 張新新, 楊洋, 劉建利, 王燕, 孫文基. 地奧心血康膠囊中甾體皂苷類成分的HPLC-ELSD指紋圖譜. 中國醫藥工業雜誌, 2015, 46(1): 65-67.

[3] 張新新, 梁晉如, 趙文娜, 郝群峰, 孫文基, 王燕. 氣相色譜法測定瑞克衛瑞消毒液中桂皮醛和丁香酚的含量. 西北大學學報（自然科學版）, 2015, 45(2): 257-260.

[4] 張新新, 楊洋, 劉勝家, 孫文基. 藏木香中土木香內酯和異土木香內酯的製備. 中國醫藥工業雜誌, 2014, 45(2): 116-119.

[5] 張新新, 梁晉如, 趙曄, 孫文基. 盾葉薯蕷藥材甾體總皂苷成分HPLC-ELSD指紋圖譜的研究. 中國中藥雜誌, 2013, 38(19): 15-20.

[6] 張新新, 梁晉如, 蘇琪, 謝人明, 孫文基. HPLC-ELSD法同時測定盾葉薯蕷根莖中5個皂苷的含量. 藥物分析雜誌, 2013, 33(7): 1235-1238.

[7] 張新新, 賈娜, 孫琛, 趙文娜, 孫文基. 大葉秦艽花與麻花秦艽花抗炎鎮痛作用的研究. 西北藥學雜誌, 2012, 27(4): 341-343.

[8] 張新新, 陳國權, 劉向輝, 王利娜, 鞏江, 倪士峰. 人中白藥學研究概況. 寧夏農林科技, 2012, 53(06): 129-130.

[9] 張新新, 許丹, 梁晉如, 孫文基. HPLC法測定忍冬藤及金銀花中馬錢苷的含量. 西北大學學報（自然科學版）, 2012, 42 (1): 38-42.

[10] 張新新, 黃亮輝, 葉根德, 王燕. 氣相色譜外標法測定川貝枇杷糖漿中薄荷腦的含量. 藥物分析雜誌, 2011, 31(5): 947-949.

科研項目

[1] 2022.01-2026.12 企業橫向課題，主持。

[2] 2022.01-2024.12 企業橫向課題，主持。

[3] 2021.01-2023.12.31 陝西省中醫藥管理局，中醫藥傳承創新暨“秦藥”開發重點研究項目，主持。

[4] 2022.01-2023.12 陝西省中醫藥管理局，25種秦藥質量標準建立，主持。

[5] 2020.01.01-2021.12.31 中醫藥優秀中青年科技骨幹人才，主持。

[6] 2020.01.01-2022.12.31 中國博士後基金（編號：2020M673429），主持。

[7] 2020.01.01-2021.12.31 陝西省自然科學基金（編號：2020JM-013），主持。

[8] 2017.01.01-2019.12.31 國家自然科學基金（編號：81603267），主持。

[9] 2017.01.01-2019.12.31 中國博士後科學基金特別資助（編號：2018T111078），主持。

[10] 2016.01.01-2017.12.31 中國博士後科學基金（編號：2016M590958），主持。

[11] 2017.01.01-2018.12.31 陝西省自然科學基金（編號：2017JQ8017），主持。

[12] 2016.01.01-2017.12.31 陝西省博士後基金（編號：2017BSHEDZZ94），主持。

[13] 2020.01.01-2022.12.31 陝西省重點研發計畫（編號：2020ZDLSF05-05），參與。

發明專利

張新新; 孫文基; 王燕; 梁晉如; 黃姜提取物在製備抗腦缺血藥物中的套用, 2017-07-25, 中國, ZL201410045440.9.

[4] Muhammad Khurm, Xingbin Wang, Hui Zhang, Sajid Nawaz Hussain, Muhammad Naeem Qaisar, Khezar Hayat, Fatima Saqib, Xinxin Zhang*, Guanqun Zhan, Zengjun Guo. The genus Cassia L.: Ethnopharmacological and phytochemical overview. Phytotherapy Research, 2020, 1-50.

[5] Xinxin Zhang, Xingbin Wang,Muhammad Khurm, Guanqun Zhan, Hui Zhang,Yoichiro Ito, Zengjun Guo. Alterations of brain quantitative proteomicsprofiling revealed the molecular mechanisms of diosgenin against cerebralischemia reperfusion effects. Journal of Proteome Research, 2020, 19(3): 1154-1168.

[6] Xinxin Zhang, Ming Jin, Nigatu Tadesse, Guanqun Zhan, Hui Zhang,Jun Dang, Sicen Wang, Zengjun Guo, Yoichiro Ito.Methods to treat the industrial wastewaterin diosgenin enterprises produced from Diosoreazingiberensis C. H. Wright. Journal of Cleaner Production. 2018, 186: 34-44.

[7] Xinxin Zhang, Guanqun Zhan, Ming Jin, Hui Zhang, Jun Dang, YanZhang, Zengjun Guo, Yoichiro Ito. Botany, traditional use, phytochemistry, pharmacology,quality control, and authentication of RadixGentianae Macrophyllae-A traditional medicine: A review. Phytomedicine,2018, 46: 142-163.

[8] Xinxin Zhang, Ming Jin, Nigatu Tadesse, Jun Dang, Tao Zhou, HuiZhang, Sicen Wang, Zengjun Guo, Yoichiro Ito. Dioscorea zingiberensis C. H. Wright: Anoverview on its Traditional Use, Phytochemistry, Pharmacology, Clinical Applications,Quality Control, and Toxicity.Journal of Ethnopharmacology, 2018, 220: 283-293.

[9] Xinxin Zhang, Ming Jin, NigatuTadesse, Liang Xian, Hui Zhang, Sicen Wang, Jun Dang, Yan Zhang, Zengjun Guo,Yoichiro Ito. Safetyinvestigation on total steroid saponins extracts from Dioscorea zingiberensis C.H. Wright: Sub-acute and chronic toxicitystudies on dogs. Regulatory Toxicology and Pharmacology, 2017, 91: 58-67.

[10] Xinxin Zhang, Dandan Li, Xuanji Xue,Yan Zhang, Jie Zhang, Chen Huang, Zengjun Guo, Nigatu Tadesse. Firsttotal synthesis of a novel amide alkaloid derived from Aconitum taipeicum andits anticancer activity. Natural Product Research, 2017, (9): 1-5.

[11] Xinxin Zhang, Xuanji Xue, Jing Zhao,Zengjun Guo, Yoichiro Ito, Wenji Sun. Quantitativedetermination of gracillin by HPLC-MS/MS after oral administration and itsapplication to a pharmacokinetic study. Steroids,2016, 113: 78-86.

[12] Xinxin Zhang, Xuanji Xue, Liang Xian,Zengjun Guo, Yoichiro Ito, Wenji Sun.Potential neuroprotection of protodioscin againstcerebral ischemia-reperfusion injury in rats through intervening inflammationand apoptosis. Steroids, 2016, 113: 52-63.

[13] XinxinZhang, Zengjun Guo,Jing Li, Yoichiro Ito, Wenji Sun. A new quantitation method of protodioscin byHPLC-ESI-MS/MS in rat plasma and its application to the pharmacokinetic study.Steroids, 2016, 106: 62-69.

[14] XinxinZhang,Xuanji Xue, Jing Zhao, Chunxiang Qian, Zengjun Guo, Yoichiro Ito, Wenji Sun. Diosgeninattenuates the brain injury induced by transient focal cerebralischemia-reperfusion in rats. Steroids, 2016, 113: 103-112.

[15] XinxinZhang, Jing Li,Yoichiro Ito, Wenji Sun. Simultaneous quantification of five steroidsaponins from Dioscorea zingiberensis C.H. Wright in rat plasma by HPLC-MS/MS and its application to thepharmacokinetic studies. Steroids, 2015, 93, 16-24.

[16] XinxinZhang, Jinru Liang,Jianli Liu, Ye Zhao, Juan Gao, Wenji Sun, Yoichiro Ito. Qualitycontrol and identification of steroid saponins from Dioscorea zingiberensis C.H.Wright by fingerprint with HPLC-ELSDand HPLC-ESI-Quadrupole/Time-of-fight tandem mass spectrometry. Journalof Pharmaceutical and Biomedical Analysis, 2014, 91: 46-59.

[17] XinxinZhang, Yoichiro Ito,Jinru Liang, Jianli Liu, Jiao He, Wenji Sun. Therapeutic effects of totalsteroid saponin extracts from the rhizome of Dioscorea zingiberensis C.H.Wright in Freund’s complete adjuvantinduced arthritis in rats. International Immunopharmacology,2014, 23, 407-416.

[18] XinxinZhang, Lin Chen, XuanDang, Jianli Liu, Yoichiro Ito, Wenji Sun. Neuroprotective effectsof total steroid saponins on cerebral ischemia injuries in an animal model offocal ischemia/reperfusion. Planta Medica,2014, 80: 637-644.

[19] XinxinZhang, Lin Chen, JianliLiu, Yoichiro Ito, Jiao He, Wenji Sun. Neuroprotection oftotal steroid saponins from Dioscoreazingiberensis against transient focal cerebral ischemia-reperfusion injuryin rats via its anti-inflammatory and anti-apoptotic effects. PlantaMedica, 2014, 80, 1597-1604.

[20]XinxinZhang, Yoichiro Ito, Jinru Liang, Qi Su, Yongmin Zhang,Jianli Liu, Wenji Sun. Preparative isolation and purification of fivesteroid saponins from Dioscoreazingiberensis C. H. Wright by counter-current chromatography coupled withevaporative light scattering detector. Journal of Pharmaceutical andBiomedical Analysis, 2013, 84: 117-123.

[21]XinxinZhang, Jianli Liu, Wenji Sun, Yoichiro Ito. Comparative Studieson Performance of CCC and Preparative RP-HPLC in Separation and Purification ofSteroid Saponins from DioscoreaZingiberensis C. H. Wright. Journal of Steroids & Hormonal Science,2015, 6(1): 1-9.

中文核心期刊

[1] 金明, 仙靚, 孫麗娜, 石碩, 張卉, 張新新, 郭增軍. 盾葉薯蕷中甾體皂苷的分離與結構鑑定. 西北藥學雜誌, 2017, (04): 395-399.

[2] 張新新, 楊洋, 劉建利, 王燕, 孫文基. 地奧心血康膠囊中甾體皂苷類成分的HPLC-ELSD指紋圖譜. 中國醫藥工業雜誌, 2015, 46(1): 65-67.

[3] 張新新, 梁晉如, 趙文娜, 郝群峰, 孫文基, 王燕. 氣相色譜法測定瑞克衛瑞消毒液中桂皮醛和丁香酚的含量. 西北大學學報（自然科學版）, 2015, 45(2): 257-260.

[4] 張新新, 楊洋, 劉勝家, 孫文基. 藏木香中土木香內酯和異土木香內酯的製備. 中國醫藥工業雜誌, 2014, 45(2): 116-119.

[5] 張新新, 梁晉如, 趙曄, 孫文基. 盾葉薯蕷藥材甾體總皂苷成分HPLC-ELSD指紋圖譜的研究. 中國中藥雜誌, 2013, 38(19): 15-20.

[6] 張新新, 梁晉如, 蘇琪, 謝人明, 孫文基. HPLC-ELSD法同時測定盾葉薯蕷根莖中5個皂苷的含量. 藥物分析雜誌, 2013, 33(7): 1235-1238.

[7] 張新新, 賈娜, 孫琛, 趙文娜, 孫文基. 大葉秦艽花與麻花秦艽花抗炎鎮痛作用的研究. 西北藥學雜誌, 2012, 27(4): 341-343.

[8] 張新新, 陳國權, 劉向輝, 王利娜, 鞏江, 倪士峰. 人中白藥學研究概況. 寧夏農林科技, 2012, 53(06): 129-130.

[9] 張新新, 許丹, 梁晉如, 孫文基. HPLC法測定忍冬藤及金銀花中馬錢苷的含量. 西北大學學報（自然科學版）, 2012, 42 (1): 38-42.

[10] 張新新, 黃亮輝, 葉根德, 王燕. 氣相色譜外標法測定川貝枇杷糖漿中薄荷腦的含量. 藥物分析雜誌, 2011, 31(5): 947-949.

科研項目

[1] 2022.01-2026.12 企業橫向課題，主持。

[2] 2022.01-2024.12 企業橫向課題，主持。

[3] 2021.01-2023.12.31 陝西省中醫藥管理局，中醫藥傳承創新暨“秦藥”開發重點研究項目，主持。

[4] 2022.01-2023.12 陝西省中醫藥管理局，25種秦藥質量標準建立，主持。

[5] 2020.01.01-2021.12.31 中醫藥優秀中青年科技骨幹人才，主持。

[6] 2020.01.01-2022.12.31 中國博士後基金（編號：2020M673429），主持。

[7] 2020.01.01-2021.12.31 陝西省自然科學基金（編號：2020JM-013），主持。

[8] 2017.01.01-2019.12.31 國家自然科學基金（編號：81603267），主持。

[9] 2017.01.01-2019.12.31 中國博士後科學基金特別資助（編號：2018T111078），主持。

[10] 2016.01.01-2017.12.31 中國博士後科學基金（編號：2016M590958），主持。

[11] 2017.01.01-2018.12.31 陝西省自然科學基金（編號：2017JQ8017），主持。

[12] 2016.01.01-2017.12.31 陝西省博士後基金（編號：2017BSHEDZZ94），主持。

[13] 2020.01.01-2022.12.31 陝西省重點研發計畫（編號：2020ZDLSF05-05），參與。

發明專利

張新新; 孫文基; 王燕; 梁晉如; 黃姜提取物在製備抗腦缺血藥物中的套用, 2017-07-25, 中國, ZL201410045440.9.