張新帥，博士，華南師範大學生命科學學院研究員。
基本介紹
- 中文名：張新帥
- 職業：教師
- 畢業院校：美國新墨西哥大學
- 學位/學歷：博士
- 專業方向：分子層面上的微生物代謝
- 任職院校：華南師範大學
個人經歷,研究方向,學術成果,
個人經歷
2012年畢業於美國新墨西哥大學(University of New Mexico),獲化學博士學位。2012年至2019年在美國伊利諾伊大學香檳分校基因組生物學研究所(Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign)從事博士後研究。2019年3月作為青年拔尖人才引進到華南師範大學生命科學學院生態科學研究所。
研究方向
主要從事分子層面上的微生物代謝研究，利用“基因組酶學”策略解析微生物新酶功能及其參與的代謝通路。解析腸道微生物中最富集的甘氨醯自由基蛋白家族新酶功能，在分子層面上闡明腸道微生物代謝膳食成分和外源性成分的生化分子基礎。
學術成果
共發表SCI收錄研究論文17篇，其中以第一作者或共同第一作者在Nature Chemical Biology，Proc. Natl. Acad. Sci. U. S. A.，J. Am. Chem. Soc.，eLife，Angew. Chem. Int. Ed.，ACS Catalysis等國際權威期刊上發表研究論文7篇。
代表性論文：
1. Carter, M. S.,Zhang, X., Huang, H., Bouvier, J. T.,San Francisco, B., Vetting, M. W.,Al-Obaidi, N.,Bonanno, J. B., Ghosh, A., Zallot, R., Andersen, H. M., Almo, S. C., and Gerlt, J. A. “Functional Assignment of Multiple Catabolic Pathways for D-apiose”Nat. Chem. Biol.2018, .Equal contribution (IF: 15.066).
2.Zhang, X.,Carter, M. S., Vetting, M. W., San Francisco, B., Zhao, S.,Al-Obaidi, N.,Solbiati, J. O., Thiaville, J. J., de Crécy-Lagard, V., Jacobson, M. P., Almo, S. C., and Gerlt, J. A. “Assignment of Function to a Domain of Unknown Function (DUF): DUF1537 is a New Kinase Family in Catabolic Pathways for Acid Sugars”Proc. Natl. Acad. Sci.U. S. A.2016,E4161-E4169 (IF: 9.423).
3.Zhang, X., Kumar, R., Vetting, M. W., Zhao, S., Jacobson, M. P., Almo, S. C., and Gerlt, J. A. “A Uniquecis-3-Hydroxy-L-Proline Dehydratase in the Enolase Superfamily”J. Am. Chem. Soc.2015,
4.Zhang, X., Song, X., Li, H., Zhang, S., Chen, X., Yu, X., and Wang, W. “An Organocatalytic Cascade Approach toward Polysubstituted Quinolines and Chiral 1,4-Dihydroquinolines-Unanticipated Effect of N-Protecting Groups”Angew. Chem. Int. Ed.,2012, (IF: 11.709) (This work was highlighted inSynfactsandChemInform)
5.Zhang, X., Zhang, S., and Wang, W. “Iminium–Allenamine Cascade Catalysis: One-Pot Access to Chiral 4H-Chromenes by a Highly Enantioselective Michael-Michael Sequence”Angew. Chem., Int. Ed.2010,(This work was highlighted inSynfactsandChemInform)
6. Zhao, S., Sakai, A.,Zhang, X., Vetting, M. W., Kumar, R., Hillerich, B.,San Francisco, B.,Solbiati, J.O., Steves, A., Brown, S., Akiva, E., Barber, A., Seidel, R. D., Babbitt, P. C., Almo, S. C., Gerlt, J. A., and Jacobson, M. P. “Prediction and Characterization of Enzymatic Activities Guided by Sequence Similarity and Genome Neighborhood Networks”eLife2014,Equal contribution (IF: 8.303)
7. Huang, H.,Zhang, X., Yu, C., Li, X., Zhang, Y., and Wang, W. “Highly Regio- and Stereoselective Synthesis ofZandEEnol Esters by an Amine-Catalyzed Conjugate Addition–Rearrangement Reaction of Ynals with Carboxylic Acids”ACS Catal.2016, .Equal contribution(IF: 9.307)
