西北大學，食品科學與工程學院，教授（三級），博士生導師；中國食品科學技術學會會員，中國化工學會會員；曾任陝西省化工學會常務理事，陝西省化工學會催化專業委員會副主任委員。
基本介紹
- 中文名：張小里
- 國籍：中國
- 學位/學歷：工學博士/博士研究生
- 專業方向：生物化工
學習經歷,工作經歷,研究方向,科研項目,學術論文,專利成果,
學習經歷
2002年7月浙江大學生物化工專業畢業,獲工學博士學位；
1991年7月西北大學化學工程專業畢業,獲工學碩士學位；
1983年7月西北大學基本有機合成專業畢業，獲工學學士學位；
曾先後公派赴日本名古屋大學留學或訪問研究。
工作經歷
1983年7月本科畢業留校西北大學化工系（學院）任教，從事化學工程和生物化工專業教學及科研工作，歷任講師、副教授、教授職稱，曾擔任生物化工教研室主任、西北大學化工系主任等職；指導生物化工、化學工程、工業催化專業碩士、博士研究生；2018年轉任西北大學食品科學與工程學院，指導生物資源化學與利用專業博士、碩士研究生。
研究方向
發酵與酶工程、催化反應工程、新資源食品及食品添加劑。
科研項目
先後主持國家自然科學基金高技術探索項目《重組酵母高密度發酵條件最佳化及基因表達規律的研究》（29886001）、陝西省重點研發計畫項目《磷脂酶D的分子改造及高性能酶製備技術研究》（2018NY-131）、橫向合作項目《可再生資源蓖麻油製備癸二酸清潔生產示範技術開發》等13項科研項目。
學術論文
代表性學術論文如下：
1. Li, Y.; Zhang, X.; Gao, S.; Guo, W.; Liu, Z.; Wu, L.;Zheng, L.; Ding, X.; Yan, H.; Wang, Y., Synthesis of the CeO2 Support with aHoneycomb-Lantern-like Structure and Its Application in Dry Reforming ofMethane Based on the Surface Spatial Confinement Strategy. The Journal ofPhysical Chemistry C 2023, 127 (2), 1032-1048.
2. Li, H.; Zhang, T.; Tang, K.; Li, B.; Zhang, X.; Zhao,B.; Wang, J., Preparation of hyperbranched 4-dimethylaminopyridine catalyst forthe efficient synthesis of vitamin E succinate. C. R. Chim. 2023,26, 11-22.
3. Zhang, T.; Li, B.; Li, H.; Liu, Y.; Li, J.; Zhao, B.;Zhang, X.; Wang, J., The efficient and green synthesis of biodiesel from crudeoil without degumming catalyzed by sodium carbonate supported MoS2. RSC Adv.2022, 12, 24456-24464.
4. Qi, X.; Li, B.;Omarini, A. B.; Gand, M.; Zhang, X.; Wang, J., Discovery of TCMs andderivatives against the main protease of SARS-CoV-2 via high throughputscreening, ADMET analysis, and inhibition assay in vitro. Journal ofMolecular Structure 2022, 1268, 133709.
5. Li, Y.; Wang, Y.; Zhang, X.; Ding, X.; Liu, Z.; Zhu,R.; Wu, L.; Zheng, L., Ni supported on natural clay of palygorskite as catalystfor dry reforming of methane: Thermodynamic analysis and impacts of preparationmethods. Int. J. Hydrogen Energy 2022, 47, 20851-20866.
6. Wang, J.; Qi, X.; Yu, W.; Zhang, X.; Zhang, T.; Li,B., Highly efficient biosynthesis of phosphatidylserine by the surfaceadsorption-catalysis in purely aqueous media and mechanism study bybiomolecular simulation. Molecular Catalysis 2021, 502,111397.
7. Zhang, T.; Li, B.; Zhang, X.; Wang, J.; Wei, L.; Zhao,B.; Li, B., 4-Dimethylaminopyridine grafted on MCM-41 as an efficient andhighly stable catalyst for the production of α-tocopherol acetate. J. PorousMat. 2020, 27 (6), 1639-1648.
8. Wei, L. H.; Li, B. L.; Zhang, X. L.; Tang, K.; Zheng,W. W.; Chen, D.; Zhao, B. X., Choline derivatives immobilized on silica tocatalyze transesterification reaction for production of glycerophosphocholine. Turk.J. Chem. 2020, 44 (1), 249-260.
9. Wang, J.; Zhang, X.; Omarini, A. B.; Li, B., Virtualscreening for functional foods against the main protease of SARS-CoV-2. Journalof Food Biochemistry 2020, 44 (11), e13481.
10. Wang, J.; Yu, W.; Zhang, X.; Zhang, T.; Wang, H.;Shu, W.; Liu, L.; Zhao, B.; Li, B., Two-step modification of silica forefficient adsorption of phosphatidylcholine in water and application inphospholipase D-catalyzed transphosphatidylation. Biotechnology Progress 2020,36 (3), e2949.
11. Sun, W.; Fu, Z.; Shi, H.; Jin, C.; Liu, E.; Zhang,X.; Fan, J., Cu3P and Ni2P co-modified g-C3N4 nanosheet with excellentphotocatalytic H2 evolution activities. Journal of Chemical Technology &Biotechnology 2020, 95 (12), 3117-3125.
12. Qi, X. Y.; Zheng, W. W.; Zhang, X. L.; Wei, L. H.;Tang, K.; Zhao, B. X.; Li, B. L., Effective synthesis of menthol derivativemonomenthyl succinate catalyzed by nanoscale silicon dioxide immobilized DMAPderivative in mixed solvent system. Comptes Rendus Chimie 2020, 23(6-7), 375-384.
13. Liu, L.; Zhang, T. T.; Zhang, X. L.; Wang, J.; Shu,W. F.; Qi, X. Y.; Zhao, B. X.; Li, B. L., An efficient method for determinationof components in docosahexaenoic acid-phosphatidylcholine using pre-columnderivatization HPLC. Rev Roum Chim 2020, 65 (10), 955-962.
14. 段丹丹; 李冰麟; 張小里; 王姣; 於文宇; 王煥; 趙彬俠, 水-固相磷脂酶D催化反應體系合成磷脂醯甘油. 化學工程 2019, 47 (05), 1-5+17.
15. 陳丹; 張小里; 李冰麟; 衛龍輝; 趙彬俠; 張耀中, 正己烷/丙酮混合溶劑中非均相催化合成α-生育酚琥珀酸酯. 化工進展 2019, 38 (09), 4095-4101.
16. Wang, J.; Yu, W.; Zhang, X.; Zhang, T.; Wang, H.;Shu, W.; Liu, L.; Zhao, B.; Li, B., Two-step modification of silica forefficient adsorption of phosphatidylcholine in water and application inphospholipase D-catalyzed transphosphatidylation. Biotechnology Progress 2019,e2949-e2949.
17. Wang, J.; Li, B. L.; Zhang, X. L.; Hu, Q. J.; Yu, W.Y.; Wang, H.; Duan, D. D.; Li, J.; Zhao, B. X., Docking and molecular dynamicsstudies on the mechanism of phospholipase D-mediated transphosphatidylation toconstruct the reaction kinetic model: Application in phosphatidylserineproduction. Journal of the Taiwan Institute of Chemical Engineers 2019,96, 82-92.
18. Sun, W. J.; Jia, J.; Jin, C. Y.; Zhang, X. L.; Liu,E. Z.; Fan, J., In situ synthesis of Cu3P/g-C3N4 heterojunction with superiorphotocatalytic hydrogen evolution. Journal of Physics D-Applied Physics 2019,52 (46).
19. Li, B. L.; Wang, J.; Li, H. Y.; Zhang, X. L.; Duan,D. D.; Yu, W. Y.; Zhao, B. X., Efficient and green aqueous-solid system fortransphosphatidylation to produce phosphatidylhydroxybutyrate: Potential drugsfor central nervous system's diseases. Biotechnology Progress 2019,35 (1).
20. Li, B.; Wang, J.; Li, J.; Zhang, X.; Yu, W.; Wang,H.; Duan, D.; Zhao, B., A comparison between continuous and batch processes toproduce phosphatidylserine in the efficient and green aqueous-solid system. BiotechnologyProgress 2019, 35 (3), e2777.
21. Li, B.; Li, H.; Zhang, X.; Fan, P.; Liu, L.; Li, B.;Dong, W.; Zhao, B., Calcined sodium silicate as an efficient and benignheterogeneous catalyst for the transesterification of natural lecithin toL-α-glycerophosphocholine. Green Processing and Synthesis 2019, 8(1), 78-84.
22. Chen, D.; Li, B.; Li, B.; Zhang, X.; Wei, L.; Zheng,W., Synthesis of vitamin E succinate catalyzed by nano-SiO2 immobilized DMAPderivative in mixed solvent system. Green Processing and Synthesis 2019,8 (1), 667-676.
23. 李環宇; 李冰麟; 王姣; 段丹丹; 張小里; 趙彬俠, 非天然磷脂化合物磷脂醯基γ-羥基丁酸的合成. 化工進展 2018, 37 (10), 4029-4032.
24. Li, B. L.; Duan, D. D.; Wang, J.; Li, H. Y.; Zhang,X. L.; Zhao, B. X., Improving phospholipase D activity and selectivity bybio-imprinting-immobilization to produce phosphatidylglycerol. J Biotechnol 2018,281, 67-73.
25. Li, B.; Chen, D.; Zhang, X. L.; Dong, W. B.; Zhao, B.X., A convenient method to immobilize 4-dimethylaminopyridine on silica gel asa heterogeneous nucleophilic catalyst for acylation. Chem. Pap. 2018,72 (6), 1339-1345.
26. 鄧楊敏; 李冰麟; 董文博; 楊開利; 張小里; 趙彬俠, 磷脂醯乙醇胺的酶促合成及底物抑制動力學. 化工進展 2017, (07), 2601-2606.
27. Zhang, X.; Li, B.; Wang, J.; Li, H.; Zhao, B.,High-Yield and Sustainable Production of Phosphatidylserine in Purely AqueousSolutions via Adsorption of Phosphatidylcholine on Triton-X-100-ModifiedSilica. J Agr Food Chem 2017, 65 (49), 10767-10774.
28. 楊蘭蘭; 張小里; 封娟娟; 朱南南; 趙彬俠, 磷脂酶D高產菌株的原生質體紫外誘變選育. 生物加工過程 2016, (02), 22-26.
29. 任方旭; 孫全蓮; 董文博; 張小里; 趙彬俠, 發酵液中鼠李糖脂的活性炭吸附-酸沉澱分離. 化學工程 2016, (07), 15-18.
30. 封娟娟; 朱南南; 鄧楊敏; 韓曉玲; 張小里; 趙彬俠, 反覆分批式反應提高磷脂醯絲氨酸的生產能力. 化工進展 2016, (04), 1180-1183.
31. 陳慶; 張小里; 王建雄, 氨基膦酸螯合樹脂吸附癸二酸中鐵離子的研究. 化學工程 2016, (03), 26-29+45.
32. Li, H.-Y.; Zhang, X.-L.; Yan, B.; Zhao, B.-X.; Gao,J., Preparation and catalytic performance of quaternary ammonium base resin formethanolysis of natural phosphatidylcholine. Chem. Pap. 2016, 70(6), 706-712.
33. Li, B. L.; Wang, J.; Zhang, X. L.; Zhao, B. X.; Niu,L., Aqueous-Solid System for Highly Efficient and Environmentally FriendlyTransphosphatidylation Catalyzed by Phospholipase D To ProducePhosphatidylserine. J Agr Food Chem 2016, 64 (40),7555-7560.
34. Li, B. L.; Wang, J.; Zhang, X. L.; Zhao, B. X., AnEnzyme Net Coating the Surface of Nanoparticles: A Simple and Efficient Methodfor the Immobilization of Phospholipase D. Ind Eng Chem Res 2016,55 (40), 10555-10565.
35. Zhang, Y.; Zhou, J.; Han, X.; Zhang, X.; Hu, J.,Kinetics behavior of long-chain n-alkanethiols adsorbed on copper surface. AppliedSurface Science 2015, 353, 979-985.
36. Zhang, Y.; Zhou, J.; Zhang, X.; Hu, J.; Gao, H.,Solvent polarity effect on quality of n-octadecanethiol self-assembledmonolayers on copper and oxidized copper. Applied Surface Science 2014,320 (0), 200-206.
37. Li, H.-Y.; Zhang, X.-L.; Zhang, J.-B.; Zhang, T.-T.;Zhao, B.-X., Preparing L-α-Glycerophosphocholine in a Phase-Transfer CatalyticReaction: Kinetic Study. Int J Chem Kinet 2014, 46 (3),169-175.
38. 王端好; 張小里, 山梨醇脫氫酶性質研究. 生物技術 2013, (01), 70-73.
39. Zhang, T.; Zhang, X.; Li, H.; Bai, W.; Zhao, B.,Kinetic evaluation of the ethanolysis of phosphatidylcholine catalyzed bycholine hydroxide. Reac Kinet Mech Cat 2013, 110 (1),31-39.
40. Li, H.; Zhang, X.; Bai, W.; Zhang, J.; Zhang, T.;Zhao, B., Study on the preparation of l-α-glycerophosphocholine catalyzed bylow boiling point organic amines. Reac Kinet Mech Cat 2013, 108(2), 305-316.
41. 章結兵; 張小里; 李紅亞; 趙彬俠, 固定床動力學模型在離子交換過程中的套用. 化學工程 2012, (05), 54-56+69.
42. 張甜甜; 張小里; 李紅亞; 豆坤坤; 王彥雄, 大豆磷脂製備甘油磷脂醯膽鹼均相催化反應研究. 套用化工 2012, (04), 599-601.
43. 王彥雄; 張小里; 李紅亞; 豆坤坤; 張甜甜; 姚娜, 蓖麻油催化裂解製備癸二酸的清潔工藝研究. 工業催化 2012, (04), 68-71.
44. 劉媛媛; 張小里; 姚娜; 李紅亞; 趙彬俠, 磷脂酶D的紫外誘變選育及發酵條件的最佳化. 化工進展 2012, (09) , 2036-2038+2063.
45. Zhang, J.; Zhang, X. L.; Li, H.; Zhao, B., IonExchange Adsorption Studies of Miglitol in a Fixed Bed. Chem Eng Technol 2012,35 (5), 811-818.
46. Li, H.; Zhang, X.; Zhang, T.; Dou, K.; Zhao, B.,Study on the methanolysis of natural lecithin catalyzed by quaternary ammoniumbase resin. Reac Kinet Mech Cat 2012, 107 (2), 345-354.
47. 章結兵; 張小里; 李紅亞; 趙彬俠; 熊柱, 米格列醇在大孔D001樹脂上的離子交換性研究. 化學工程 2011, (08).
48. Jia, Z.; Zhang, X.; Cao, X.; Liu, J.; Qin, B.,Production of lovastatin by a self-resistant mutant of Aspergillus terreus. AnnMicrobiol 2011, 61 (3), 615-621.
49. Jia, Z. H.; Zhang, X. L.; Zhao, Y. L.; Cao, X. J.,Enhancement of Lovastatin Production by Supplementing Polyketide Antibiotics tothe Submerged Culture of Aspergillus terreus. Appl Biochem Biotech 2010,160 (7), 2014-2025.
50. 張耀中; 趙彬俠; 張小里; 劉林學; 章毅; 曹昕; 路程, Fe2O3/SiO2對異辛醇氧化生成異辛酸反應的催化性能研究. 分子催化 2009, (06), 529-533.
專利成果
[1] 張小里，唐凱，劉力，舒文芳，衛龍輝，張甜甜，李冰麟，趙彬俠，一種枝化型高固載4-二甲氨基吡啶催化劑及其製備方法，ZL202010491322.6
[2] 張小里，王姣，李冰麟，段丹丹，趙彬俠，董文博，一種提高磷脂醯甘油合成反應活力的磷脂酶D固定化方法，ZL201710092814.6
[3] 張小里，董文博，李彬，鄧楊敏，李冰麟，趙彬俠，一種負載化4-(N,N-二甲基)氨基吡啶催化劑的製備方法，ZL201710004539.8
[4] 張小里，李紅亞，梁江，張希雙，趙彬俠，一種天然L-α-甘油磷脂醯膽鹼的製備方法，ZL201210513309.1
[5] 張小里，周萬嵇，翟繼博，趙彬俠，一種蓖麻油類化合物裂解製備癸二酸的方法，ZL201310597679.2
[6] 張小里，李紅亞，張甜甜，豆坤坤，趙彬俠，一種天然L-α-甘油磷脂醯膽鹼及其製備方法，ZL201110349727.7
