張兆國(上海交通大學化學化工學院教授)

張兆國，1968年11月出生於山東，上海交通大學博士，上海交通大學化學與化工學院教授。

基本介紹

• 中文名：張兆國
• 畢業院校：上海交通大學
• 學位/學歷：博士
• 專業方向：金屬有機化學與不對稱催化、精細有機合成
• 職稱：上海交通大學化學與化工學院教授

基本信息

1968年11月出生於山東

1987-1991：山東大學化學系畢業，獲學士學位

1991-1994：南京大學化學系畢業，獲碩士學位 導師：徐建華教授

1994-1997：中國科學院上海有機化學研究所畢業，獲博士學位 導師：陸熙炎院士

1997-2000：賓夕法尼亞州立大學化學系博士後 導師：張緒穆教授

2000，6- ：中國科學院上海有機化學研究所研究員

2000年度中國科學院百人計畫

2002年上海市科技啟明星

2004年中國科學院優秀研究生導師

2006年科技啟明星跟蹤

2007年曙光學者

2005-至今：上海交通大學化學與化工學院，教授

研究興趣

1、金屬有機化學與不對稱催化

2、精細有機合成
3、可見光條件下的催化反應

科研項目

主持和參加國家自然科學基金項目、中國科學院基金項目、國家重點實驗室開放基金項目和國際、國內企業合作項目。

榮譽獎勵

1、2000年獲中國科學院百人計畫
2、2002年獲上海市“科技啟明星”
3、2004年被評為中國科學院優秀研究生導師2
4、2006年獲得美國Eli Lilly Research Excellence Award
5、2007年獲上海市曙光學者

學術兼職

美國化學會會員

教學工作

1、本科生：《有機合成》、
2、研究生：《高等有機合成》

發表論文

Zhu, L., Chen, H., Meng, Q., Fan, W., Xie, X., Zhang, Z., "Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids." Tetrahedron 2011, 67 (34), 6186-6190.

Yao, Y., Fan, W., Li, W., Ma, X., Zhu, L., Xie, X., Zhang, Z., "Synthesis of (S)-7-amino-5-azaspiro[2.4]heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropanecarboxylates." J. Org. Chem. 2011, 76 (8), 2807-2813.

Yang, Y., Chen, L., Zhang, Z., Zhang, Y., "Palladium-catalyzed oxidative C-H bond and C=C double bond cleavage: C-3 acylation of indolizines with α,β-unsaturated carboxylic acids." Organic Letters 2011, 13 (6), 1342-1345.

Xie, X., Ni, G., Ma, F., Ding, L., Xu, S., Zhang, Z., "Palladium-catalyzed monoarylation of aryl amine with aryl tosylates." Synlett 2011, (7), 955-958.

Ma, F. F., Peng, Z. Y., Li, W. F., Xie, X. M.,Zhang, Z., "An efficient Pd-catalyzed coupling of hydrazine derivatives with aryl halides." Synlett 2011, (17), 2555-2558.

Ma, F., Xie, X., Ding, L., Gao, J., Zhang, Z., "Palladium-catalyzed coupling reaction of amino acids (esters) with aryl bromides and chlorides." Tetrahedron 2011, 67 (48), 9405-9410.

Li, X., Ma, X., Li, W., Tao, X., Meng, Q., Fan, W., Zhang, Z., "Catalytic asymmetric hydrogenation of ethyl 2-(benzo[b]thiophen-5-yl)-2- oxoacetate with ru-sunphos in the formal synthesis of T-588." Chinese Journal of Chemistry 2011, 29 (12), 2581-2583.

Li, W., Ma, X., Fan, W., Tao, X., Li, X., Xie, X., Zhang, Z., "Ru-catalyzed asymmetric hydrogenation of 3-oxoglutaric acid derivatives via solvent-assisted pinpoint recognition of carbonyls in close chemical propinquity." Organic Letters 2011, 13 (15), 3876-3879.

Fan, W., Li, W., Ma, X., Tao, X., Li, X., Yao, Y., Xie, X., Zhang, Z., "Ru-catalyzed asymmetric hydrogenation of γ-heteroatom substituted β-keto esters." J. Org. Chem. 2011, 76 (22), 9444-9451.

Zhu, L., Meng, Q., Fan, W., Xie, X., Zhang, Z., "Direct asymmetric hydrogenation of 2-oxo-4-arylbut-3-enoic acids." J. Org. Chem. 2010, 75 (17), 6027-6030.

Xie, X., Ding, L., Ni, G., Zhang, Z., Gao, J., "A general and facile approach for the synthesis of 2'-functionalized 1,1'-binapthyl-2-ols." Chinese Journal of Chemistry 2010, 28 (9), 1630-1634.

Wang, J., Tong, X., Xie, X., Zhang, Z., "Rhodium-catalyzed activation of C(sp3)-X (X = Cl, Br) bond: An intermolecular halogen exchange case." Organic Letters 2010, 12 (23), 5370-5373.

Peng, Z. Y., Ma, F. F., Zhu, L. F., Xie, X. M., Zhang, Z., "Lewis acid promoted carbon - Carbon double-bond formation via organozinc reagents and carbonyl compounds." J. Org. Chem. 2009, 74 (17), 6855-6858.

Lin, X., Busch-Petersen, J., Deng, J., Edwards, C., Zhang, Z., Kerns, J. K., "Efficient and scalable synthesis of 3,5,7-trisubstituted 1H-indazoles as potent IKK2 inhibitors." Synlett 2008, (20), 3216-3220.

Xie, X., Zhang, T. Y., Zhang, Z., "Synthesis of bulky and electron-rich MOP-type ligands and their applications in palladium-catalyzed C-N bond formation." J. Org. Chem. 2006, 71 (17), 6522-6529.

Zhu, L., Chen, H., Meng, Q., Fan, W., Xie, X., Zhang, Z., "Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids." Tetrahedron 2011, 67 (34), 6186-6190.

Yao, Y., Fan, W., Li, W., Ma, X., Zhu, L., Xie, X., Zhang, Z., "Synthesis of (S)-7-amino-5-azaspiro[2.4]heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropanecarboxylates." J. Org. Chem. 2011, 76 (8), 2807-2813.

Xie, X., Zhang, T. Y., Zhang, Z., "Synthesis of bulky and electron-rich MOP-type ligands and their applications in palladium-catalyzed C-N bond formation." J. Org. Chem. 2006, 71 (17), 6522-6529.

Wang, D.; Zhang, Z. “Activation and reaction of carboxylic anhydride catalyzed by palladium ” Chin. J. Org. Chem.2004, 24, 258-269.

Guo, M.; Li, D.; Sun, Y.; Zhang, Z. “Selective Reduction of the Carbonyl Group in b,g-Unsaturated a-Ketoesters by Transfer Hydrogenation with Ru-TsDPEN” Synlett, 2004, 741-743

Luo, Y.; Wang, F.; Zhu, G.; Zhang, Z. “A concise synthesis of 2-diarylphosphino-20-methoxy-1,10-binaphthalenes (MOPs) by simple resolution”, Tetrahedron Asymm. 2004, 15, 15-17.

Guo, M.; Li, D.; Zhang, Z. “Novel Synthesis of 2-Oxo-3-butynoates by Copper-Catalyzed Cross-Coupling Reaction of Terminal Alkynes and Monooxalyl Chloride”, J. Org. Chem. 2003, 68, 10172-10175.

Wang, D.; Zhang, Z. “Palladium-Catalyzed Cross-Coupling Reactions of Carboxylic Anhydrides with Organozinc Reagents”, Org. Lett., 2003, 5, 4645-4648.

Zhu, G.; Zhang, Z. “Palladium-Catalyzed Tandem Cyclization/Suzuki Coupling of 1,6-Enynes”, Org. Lett., 2003, 5, 3645-3648.

Cheng, J.; Wang, F.; Xu, J.-H.; Pan, Y.; Zhang, Z. “Palladium-catalyzed Suzuki–Miyaura reaction using aminophosphine as ligand”, Tetrahedron Lett., 2003, 44, 7095-7098.

Tong, X., Zhang, Z., Zhang, X., “Novel Rhodium-Catalyzed Cycloisomerization of 1,6-Enynes with an Intramolecular Halogen Shift” J. Am. Chem. Soc. 2003, 125, 6370-6371.

Zhang, Z.; Lu, X*. and Lang, S. “An Unexpected Reaction of Allyl Propynoate under Palladium Catalysis” Chin. J. Chem. 2002, 20, 1287-1290.

Wang, F. and Zhang Z.* “Palladium Catalyzed Amidocarbonylation”, Chin. J. Org. Chem. 2002, 22, 536-542.

Tian, J. Z.; Zhang, Z. G.; Yang, X. L.; Fun, K. H. and Xu*, J. H “Photooxygenation of Indolizines via Selective Excitation of Their Charge Transfer Complexes with Molecular Oxygen” J. Org. Chem. 2001, 66, 8230-8235

Zhang,Z.; Lu, X.*; Xu, Z.; Zhang, Q. and Han, X. “Role of Halide Ions in Divalent Palladium-Mediated Reactions: Competition between ‚-Heteroatom Elimination and ‚-Hydride Elimination of a Carbon-Palladium Bond”, Organometallics 2001, 20, 3724-3728

Zhang, Z.; Qian, H.; Longmire, J. and Zhang, X*. “Synthesis of Chiral Bisphosphines with Tunable Bite Angles and Their Applications in Asymmetric Hydrogenation of –Ketoesters”, J. Org. Chem. 2000; 65; 6223-6226.

Li, W.; Zhang, Z.; Xiao, D. and Zhang, X*. “Synthesis of Chiral hydroxl Phosphines from D-Mannitol and Their Use in Asymmetric Catalytic Reactions” J. Org. Chem., 2000, 65, 3489-3496.

Wang, Z.; Zhang, Z.; Lu, X*. “Effect of Halide Ligands on the Reactivity of Carbon-Palladium Bonds: Implications for Designing Catalytic Reactions” Organometallics, 2000, 19, 775-780.

Li, W.; Zhang, Z.; Xiao, D.; Zhang, X*. “Rhodium-hydroxyl bisphospholane catalyzed highly enantioselective hydrogenation of dehydroamino acids and esters” Tetrahedron Lett., 1999, 40, 6701-6704.

Jiang, Q.; Xiao, D.; Zhang, Z.; Cao, P.; Zhang, X*. “Highly enantioselective hydrogenation of cyclic enol acetates catalyzed by a Rh-PennPhos complex” Angew. Chem., Int. Ed., 1999, 38, 516-518.

Zhang, Z.; Zhu, G.; Jiang, Q.; Xiao, D.; Zhang, X*. Highly Enantioselective Hydrogenation of Cyclic Enamides Catalyzed by a Rh-PennPhos Catalyst” J. Org. Chem., 1999, 64, 1774-1775.

Xiao, D.; Zhang, Z.; Zhang, X*. “Synthesis of a Novel Chiral Binaphthyl Phospholane and Its Application in the Highly Enantioselective Hydrogenation of Enamides” Org. Lett., 1999, 1, 1679-1681.

Xiao, D.; Zhang, Z.; Jiang, Q.; Zhang, X.. “Syntheses of novel chiral 2,5-dialkyl-7- azabicyclo[2.2.1]heptanes and 2,5-dialkyl-7-thiobicyclo[2.2.1]heptanes” Tetrahedron Lett., 1998, 39, 5331-5334.

Wang, Z.; Lu, X*.; Lei, A.; Zhang, Z. “Efficient Preparation of Functionalized (E,Z) Dienes Using Acetylene as the Building Block” J. Org. Chem., 1998, 63, 3806-3807.

Lu, X*.; Zhu, G.; Wang, Z.; Ma, S.; Ji, J.; Zhang, Z. “Enyne cyclization methodology for the synthesis of bioactive lactones” Pure Appl. Chem., 1997, 69, 553-558.

Lu, X.; Zhu, G.; Wang, Z.; Ma, S.; Ji, J.; Zhang, Z. “Enyne cyclization methodology for the synthesis of bioactive lactones” Youji Huaxue, 1997. 17, 8-11.

Zhang, Z.; Lu, X*. “Total synthesis of phaseolinic acid by enyne cyclization” Tetrahedron: Asymm. 1996, 7, 1923-1928.

Xu, J.; Song, Y.; Zhang, Z.; Wang, L.; Xu, J*. “Photoinduced addition reactions of chloranil with alkenes - factors influencing the reaction site” Tetrahedron, 1994, 50, 1199-1210.

Chen, C.; Zhang,Z.; Yan, B.; Xu, J*. “Phtoinduced Reactions of Chloranil with Aromatic Imines” Tetrahedron Lett. 1994, 35, 9221-9224.

Yan, B.; Zhang, Z.; Yuan, H.; Wang, L. and Xu, J*. “Photoinduced Electron- transfer Reactions of Chloranil with Benzodioxoles” J. Chem. Soc. Perk. T 2, 1994, 2545-2550.