人物經歷,教育經歷,工作經歷,講授課程,學術成果,科研項目,論著一覽,相關成果,獲獎情況,
人物經歷
教育經歷
碩士（1994-1997）：南開大學化學學院
博士（1997-2000）：中山大學化學與化學工程學院
訪問學者 (2000-2003)：香港科技大學化學系
博士後（2004-2005）：美國Texas A&M大學化學系
工作經歷
講師（2000-2002）：中山大學化學與化學工程學院
副教授（2002-2007）：中山大學化學與化學工程學院
教授（2007-2016）：中山大學化學與化學工程學院
教授（2016-至今）：中山大學化學學院
2002年6月：被遴選為中山大學無機奔艱漿化學專業、化學生物學專業碩士生導師
2006年11月：被遴選為中山大學無機化學專業博士生導師
2008年10月：被批准為中山大學化學生物學專業博士生導師
2005年-至今：生物無機與合成化學教育部重點實驗室固定研究人員
講授課程
1. 本科生嬸舉踏：《化學學習與研究》、《無機化學》、《無機化學實驗》、《普通化學》、《現代化學》（逸仙班）、《化學生物學實驗》、《今日化學》、《化學前沿》（基礎學科拔尖學生培養實驗班）
2. 研究生：《配位化學》、《化轎危學前沿進駝夜擔展》
學術成果
科研項目
承擔國家自然科學基金（鍵捆紙包括國家傑出青年科學基金項目、重大研究計畫培育項目、面上項目、青年項目）、973計畫課題、教育部新世紀優秀人才支持計畫項目、教育部創新團隊項目（核心成茅乘促跨員）、教育部科學技術研究重點項目、教育部高校博士點基金博導類課題、教育部留學回國人員科研啟動基金、廣東省自然科學基金團隊項目（核心成員）、廣東省自然科學基金自由項目、國家重點實驗室開放基金和中山大學青年教師重點培育計畫等20多項課題研究。
論著一覽
1. Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao*, Zhe-Sheng Chen*, "The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials",Chem. Soc. Rev., 46 (2017) 5771-5804.(Inside front cover)
2. Kangqiang Qiu, Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Organelle-targeting metal complexes: From molecular design to bio-applications”辯糠記故,Coord. Chem. Rev., 2018, DOI: 10.1016/j.ccr.2017.10.022.
3. Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke,Liangnian Ji, Hui Chao*, “Harnessing ruthenium(II) as photodynamic agents: encouraging advances in cancer therapy”,Coord. Chem. Rev., 363 (2018) 17–28.
4. Yu Chen†, Ruilin Guan† (†equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao∗, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”,Coord. Chem. Rev., 310 (2016) 16-40.
5. Guanying Li, Ruilin Guan, Liangnian Ji, Hui Chao*, “DNA condensation induced by metal complexes”,Coord. Chem. Rev., 281 (2014) 100-113.
6. Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Mitochondrial dynamics tracking with iridium(III) complexes”,Curr. Opin. Chem. Biol., 43 (2018) 51-57.
7. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang,Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”,Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.
8. Pingyu Zhang†, Cookson K. C. Chiu† (†equal contributors), Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O’Connor*, Hui Chao*, Peter J. Sadler*, "Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells",Angew. Chem. Int. Ed., 56 (2017) 14898-14902.(VIP Article,Inside front cover)
9. Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser,* Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”,Angew. Chem. Int. Ed., 54 (2015) 14049-14052.(VIP Article)
10. Ruilin Guan, Yu Chen, Leli Zeng, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Zhe-Sheng Chen, Liangnian Ji, Hui Chao*, “Oncosis-inducing cyclometalated iridium(III) complexes”,Chem. Sci., 9 (2018) 5183–5190.
11. Guanying Li, Yu Chen,Jinquan Wang, Qian Lin, Jing Zhao, Liangnian Ji, Hui Chao*, “A dinuclear iridium(III) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells”,Chem. Sci., 4 (2013) 4426-4433.
12. Huaiyi Huang†, Liang Yang† (†equal contributors), Pingyu Zhang, Kangqiang Qiu, Juanjuan Huang, Yu Chen, JiaJie Diao, Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, "Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes",Biomaterials, 83 (2016) 321-331.
13. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Bole Yu, Kangqiang Qiu, Juanjuan Huang, Shutao Wang,Lei Jiang,Gilles Gasser,Liangnian Ji,Hui Chao*, “Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: a way towards cancer therapy?”,Biomaterials, 63 (2015) 102-114.
14. Guanying Li, Yu Chen, Jinquan Wang, Jingheng Wu, Gilles Gasser, Liangnian Ji, Hui Chao*, “Direct imaging of biological sulfur dioxide derivativesin vivousing a two-photon phosphorescent probe”,Biomaterials, 63 (2015) 128-136.
15. Xiang Chen, Lingli Sun, Yu Chen, Xiaolin Cheng, Weijun Wu, Liangnian Ji, Hui Chao*, “A fast and selective two-photon phosphorescent probe for theimaging of nitric oxide in mitochondria”,Biomaterials, 58 (2015) 72-81.
16. Jiangping Liu, Yu Chen, Guanying Li, Pingyu Zhang, Chengzhi Jin, Leli Zeng, Liangnian Ji, Hui Chao*, "Ruthenium(II) polypyridyl complexes asmitochondria-targeted two-photon photodynamic anticancer agents",Biomaterials, 56 (2015) 140-153.
17. Pingyu Zhang†, Huaiyi Huang† (†equal contributors), Yu Chen, Jinquan Wang, Liangnian Ji, Hui Chao*, “Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo”,Biomaterials, 53 (2015) 522-531.
18. Guanying Li†, Qian Lin† (†equal contributors), Lingli Sun, Changsheng Feng, Pingyu Zhang, Bole Yu,Yu Chen, Ya Wen, Hui Wang, Liangnian Ji, Hui Chao*, “A mitochondrial targeted two-photon iridium(III) phosphorescent probe for selective detection of hypochlorite in live cells and in vivo”,Biomaterials, 53 (2015) 285-295.
19. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Hongmin Chen, Ruilin Guan, Yu Chen, Liangnian Ji, Hui Chao*, “RuNH2@AuNPs as two-photon luminescent probes for thiols in living cells and tissues”,Biomaterials, 35 (2014) 9003-9011.
20. Yu Chen†, Liping Qiao† (†equal contributors), Liangnian Ji, Hui Chao*, “Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking”,Biomaterials, 35 (2014) 2-13.
21. Kangqiang Qiu, Jinquan Wang, Cuilan Song, Lili Wang, Hongyi Zhu, Huaiyi Huang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Crossfire for two-photon photodynamic therapy with fluorinated ruthenium(II) photosensitizers”,ACS Appl. Mater. Interfaces, 9 (2017) 18482-18492.
22. Kangqiang Qiu, Huaiyi Huang, Bingyang Liu, Yukang Liu, Ziyi Huang, Yu Chen, Liangnian Ji, Hui Chao*, "Long-Term Lysosomes Tracking with A Water-Soluble Two-Photon Phosphorescent Iridium(III) Complex",ACS Appl. Mater. Interfaces, 8 (2016) 12702-12710.
23. Pingyu Zhang, Huaiyi Huang, Juanjuan Huang, Hongmin Chen, Jinquan Wang, Kangqiang Qiu, Donglei Zhao, Liangnian Ji, Hui Chao*, “Non-Covalent Ruthenium(II) Complexes–Single Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation”,ACS Appl. Mater. Interfaces, 7 (2015) 23278-23290.
24. Cheng Ouyang,Lei Chen, Thomas W. Rees, Yu Chen* Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, “A mitochondria-targeting hetero-binuclear Ir(III)-Pt(II) complex induces necrosis in cisplatin-resistant tumor cells”,Chem. Commun., 2018, DOI: 10.1039/C8CC02795A.
25. Kangqiang Qiu†, Libing Ke† (†equal contributors), Xuepeng Zhang, Yukang Liu, Thomas W. Rees, Liangnian Ji, Jiajie Diao*, Hui Chao*, “Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(III) complexes”,Chem. Commun., 54 (2018) 2421-2424.
26. Pingyu Zhang*, Yi Wang, Kangqiang Qiu, Zhiqian Zhao, Rentao Hu, Chuanxin He, Qianling Zhang*, Hui Chao*, “NIR phosphorescent osmium(II) complex as lysosome tracking reagent andphotodynamictherapeutics”,Chem. Commun., 53 (2017) 12341-12344.
27. Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Rational design of NIR-emitting iridium(III) complexes for multimodal phosphorescence imaging of mitochondria under two-photon excitation”,Chem. Commun., 53 (2017) 10374-10377.
28. Jiangping Liu, Chengzhi Jin, Bo Yuan, Yu Chen, Xingguo Liu, Liangnian Ji, Hui Chao*, “Enhanced cancer therapy by marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes”,Chem. Commun., 53 (2017) 9878-9881.
29. Jiangping Liu†, Chengzhi Jin† (†equal contributors), Bo Yuan, Xingguo Liu, Yu Chen, Liangnian Ji, Hui Chao*, “Selectively Lighting Up Two-Photon Photodynamic Activity in Mitochondria with AIE-Active Iridium(III) Complexes”,Chem. Commun., 53 (2017) 2052-2055.
30. Leli Zeng†, Shi Kuang† (†equal contributors), Guanying Li, Chengzhi Jin, Liangnian Ji, Hui Chao*, “A GSH-activatableruthenium(II)-azo photosensitizerfor two-photon photodynamic therapy”,Chem. Commun., 53 (2017) 1977-1980.
31.Bole Yu,Ying Chen,Mei Hong,Pingping Duan,Shifeng Gan,Hui Chao*,Zujin Zhao*,Jing Zhao*, "Rhodium-catalyzed C–H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties",Chem Commun., 51 (2015) 14365-14368.
32. Wenchao Xu, Jiarui Zuo, Lili Wang, Liangnian Ji, Hui Chao*, “Dinuclear ruthenium(II) polypyridyl complexes as single and two-photon luminescence cellular imaging probes”,Chem. Commun., 50 (2014) 2123-2125.
33. Yu Chen†, Liping Qiao† (†equal contributors), Bole Yu, Guanying Li,Chunyuan Liu,Liangnian Ji, Hui Chao*, “Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(III) complex”,Chem. Commun., 49 (2013) 11095-11097.
34. Guanying Li, Yu Chen, Jingheng Wu, Liangnian Ji, Hui Chao*, “Thiol-specific phosphorescent imaging in living cells with an azobis(2,2¢-bipyridine)-bridged dinuclear iridium(III) complex”,Chem. Commun., 49 (2013) 2040-2042.
35. Bole Yu, Yu Chen, Cheng Ouyang, Huaiyi Huang, Liangnian Ji, Hui Chao*, “A luminescent tetranuclear ruthenium(II) complex as atracking non-viral gene vector”,Chem. Commun., 49 (2013) 810-812.
36. Guo-Liang Liao, Xiang Chen, Liang-Nian Ji, Hui Chao*, “Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex”,Chem. Commun., 48 (2012) 10781-10783.
37. Huaiyi Huang, Pingyu Zhang, Bole Yu, Yu Chen, Jinquan Wang, Liangnian Ji and Hui Chao*, "Targeting Nucleus DNA with a Cyclometalated Dipyridophenazine Ruthenium(II) Complex",J. Med. Chem., 57 (2014) 8971-8983.(Highlight as Highly Cited Article of 2014 of J Med Chem)
38. Xiaoda Song, Yong Qian, Rong Ben, Xiang Lu, Hai-Liang Zhu*, Hui Chao* and Jing Zhao*, “Activation of C−H bonds in nitrones leads to iridium hydrides with antitumor activity”,J. Med. Chem., 56 (2013) 6531-6535.
39. Shanshan Zou, Guanying Li, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Yu Chen, Liangnian Ji, Hui Chao*, “Interfering DNA high-order structures with chiral ruthenium(II) complexes”,Chem. Eur. J.,24 (2018) 690-698.
40. Jeannine Hess†, Huaiyi Huang† (†equal contributors),Adrian Kaiser, Vanessa Pierroz, Olivier Blacque, Hui Chao*, Gilles Gasser*, "Evaluation of the medicinal potential of two ruthenium(II) polypyridine complexes as one- and two-photon photodynamic therapy photosensitizers",Chem. Eur. J.,23 (2017) 9888-9896.(VIP Article, Highlight on ChemistryViews “Fighting Cancer with Ruthenium Complexes”)
41. Lingli Sun, Yu Chen, Shi Kuang, Guanying Li, Ruilin Guan, Jiangping Liu, Liangnian Ji, Hui Chao*, “Iridium(III) Anthraquinone Complexes asTwo-photon Phosphorescence Probes for Mitochondria Imaging and Tracking under Hypoxia”,Chem. Eur. J., 22 (2016) 8955-8965.(Hot paper).
42. Leli Zeng, Yu Chen, Huaiyi Huang, Jinquan Wang, Donglei Zhao, Liangnian Ji, Hui Chao*, “Cyclometalated Ruthenium(II)Anthraquinone Complexes ExhibitStrong Anticancer Activity inHypoxic Tumor Cells”,Chem. Eur. J., 21 (2015) 15308-15319. (Hot paper, Highlight on ChemistryViews “Combating Drug Resistance in Hypoxic Tumor Cells”)
43. Chengzhi Jin, Jiangping Liu, Yu Chen, Leli Zeng, Ruilin Guan, Cheng Ouyang, Liangnian Ji, Hui Chao*, “Cyclometalated Iridium(III) Complexes as Two-Photon Phosphorescent Probes for Specific Mitochondrial Dynamics Tracking in Living Cells”,Chem. Eur. J. 21 (2015) 12000-12010.(Highlight as Frontispiece)
44. Li Xu†, Xiang Chen† (†equal contributors), Jingheng Wu, Jinquan Wang, Liangnian Ji, Hui Chao*, “Dinuclear Ruthenium(II) Complexes that Induce and Stabilize G-quadruplex DNA”,Chem. Eur. J., 21 (2015) 4008-4020.
45. Bole Yu, Cheng Ouyang, Kangqiang Qiu, Jing Zhao, Liangnian Ji, Hui Chao*, “Lipophilic Tetranuclear Ruthenium(II) Complexes asTwo-Photon Luminescent Tracking Non-Viral Gene Vectors”,Chem. Eur. J., 21 (2015) 3691-3700.
46. Huaiyi Huang, Pingyu Zhang, Hongmin Chen, Liangnian Ji, Hui Chao*, “A Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities on 2D and 3D Cancer Models”,Chem. Eur. J., 21 (2015) 715-725.
47. Pingyu Zhang†,Lingmin Pei†, Yu Chen† (†equal contributors), Wenchao Xu, Qitian Lin, Jinquan Wang, Jingheng Wu, Yong Shen, Liangnian Ji and Hui Chao*, “A dinuclear ruthenium(II) complex as a one- and two-photon luminescent probe for biological Cu2+detection”,Chem. Eur. J., 19 (2013) 15494-15503.(Highlight as Frontispiece)
相關成果
先後在《Chem.Soc. Rev》、《Coord.Chem. Rev》、《PNAS》、《Angew. Chem. Int. Ed.》、《Chem. Sci.》、《Biomaterials》、《ACS Appl. Mater. Interfaces》、《Chem. Commun.》、《J. Med. Chem.》、《Chem. Eur. J》等國際期刊發表第一作者或通訊作者SCI論文163篇，論文被引用4600多次。參編著作 “Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine” (德國 John Wiley & Son出版公司出版, 2005年)和“生物無機化學導論”（第三版）（科學出版社，2010年）。申請中國發明專利16件, 授權12件。目前擔任中國化學會化學生物學專業委員會委員、《Scientific Reports》編委、《Journal of Inorganic Biochemistry》編委、《大學化學》編委。
獲獎情況
2001年獲中國高校自然科學獎二等獎（第九完成人）
2005年獲中國化學會“青年化學獎”
2006年入選教育部“新世紀優秀人才支持計畫”
2006年入選廣東省高等學校“千百十工程”人才培養計畫（校級）
2007年獲 中山大學化學與化工學院“53獎教金”
2011年獲廣東省科學技術獎一等獎（第二完成人）
2011年被評為中山大學校級教學名師
2012年獲國家自然科學獎二等獎（第三完成人）
2012年獲中山大學第七屆校級教學成果獎一等獎（第一完成人）
2012年獲中山大學第七屆校級教學成果獎一等獎（第四完成人）
2012年被評為南粵優秀教師（廣東省）
2013年獲中山大學化學與化工學院“芙蘭勵教獎”
2014年獲廣東省教育教學成果獎（高等教育）一等獎（第一完成人）
2014年獲廣東省教育教學成果獎（高等教育）二等獎（第四完成人）
2014年獲中山大學化學與化工學院“施開良教學管理創新獎”
2014年獲寶鋼優秀教師獎
2015年獲“國家傑出青年科學基金”
2016年入選廣東特支計畫“百千萬工程領軍人才”
2017年獲中山大學第八屆校級教學成果獎二等獎（第一完成人）
2017年獲中山大學第八屆校級教學成果獎一等獎（第五完成人）
2017年獲廣東省教育教學成果獎（高等教育）一等獎（第五完成人）
3. Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke,Liangnian Ji, Hui Chao*, “Harnessing ruthenium(II) as photodynamic agents: encouraging advances in cancer therapy”,Coord. Chem. Rev., 363 (2018) 17–28.
4. Yu Chen†, Ruilin Guan† (†equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao∗, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”,Coord. Chem. Rev., 310 (2016) 16-40.
5. Guanying Li, Ruilin Guan, Liangnian Ji, Hui Chao*, “DNA condensation induced by metal complexes”,Coord. Chem. Rev., 281 (2014) 100-113.
6. Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Mitochondrial dynamics tracking with iridium(III) complexes”,Curr. Opin. Chem. Biol., 43 (2018) 51-57.
7. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang,Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”,Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669.
8. Pingyu Zhang†, Cookson K. C. Chiu† (†equal contributors), Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O’Connor*, Hui Chao*, Peter J. Sadler*, "Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells",Angew. Chem. Int. Ed., 56 (2017) 14898-14902.(VIP Article,Inside front cover)
9. Huaiyi Huang†, Bole Yu† (†equal contributors), Pingyu Zhang, Juanjuan Huang, Yu Chen, Gilles Gasser,* Liangnian Ji, Hui Chao*, “Highly charged ruthenium(II) polypyridyl complexes as lysosome-localized photosensitizers for two-photon photodynamic therapy”,Angew. Chem. Int. Ed., 54 (2015) 14049-14052.(VIP Article)
10. Ruilin Guan, Yu Chen, Leli Zeng, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Zhe-Sheng Chen, Liangnian Ji, Hui Chao*, “Oncosis-inducing cyclometalated iridium(III) complexes”,Chem. Sci., 9 (2018) 5183–5190.
11. Guanying Li, Yu Chen,Jinquan Wang, Qian Lin, Jing Zhao, Liangnian Ji, Hui Chao*, “A dinuclear iridium(III) complex as a visual specific phosphorescent probe for endogenous sulphite and bisulphite in living cells”,Chem. Sci., 4 (2013) 4426-4433.
12. Huaiyi Huang†, Liang Yang† (†equal contributors), Pingyu Zhang, Kangqiang Qiu, Juanjuan Huang, Yu Chen, JiaJie Diao, Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, "Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes",Biomaterials, 83 (2016) 321-331.
13. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Bole Yu, Kangqiang Qiu, Juanjuan Huang, Shutao Wang,Lei Jiang,Gilles Gasser,Liangnian Ji,Hui Chao*, “Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: a way towards cancer therapy?”,Biomaterials, 63 (2015) 102-114.
14. Guanying Li, Yu Chen, Jinquan Wang, Jingheng Wu, Gilles Gasser, Liangnian Ji, Hui Chao*, “Direct imaging of biological sulfur dioxide derivativesin vivousing a two-photon phosphorescent probe”,Biomaterials, 63 (2015) 128-136.
15. Xiang Chen, Lingli Sun, Yu Chen, Xiaolin Cheng, Weijun Wu, Liangnian Ji, Hui Chao*, “A fast and selective two-photon phosphorescent probe for theimaging of nitric oxide in mitochondria”,Biomaterials, 58 (2015) 72-81.
16. Jiangping Liu, Yu Chen, Guanying Li, Pingyu Zhang, Chengzhi Jin, Leli Zeng, Liangnian Ji, Hui Chao*, "Ruthenium(II) polypyridyl complexes asmitochondria-targeted two-photon photodynamic anticancer agents",Biomaterials, 56 (2015) 140-153.
17. Pingyu Zhang†, Huaiyi Huang† (†equal contributors), Yu Chen, Jinquan Wang, Liangnian Ji, Hui Chao*, “Ruthenium(II) anthraquinone complexes as two-photon luminescent probes for cycling hypoxia imaging in vivo”,Biomaterials, 53 (2015) 522-531.
18. Guanying Li†, Qian Lin† (†equal contributors), Lingli Sun, Changsheng Feng, Pingyu Zhang, Bole Yu,Yu Chen, Ya Wen, Hui Wang, Liangnian Ji, Hui Chao*, “A mitochondrial targeted two-photon iridium(III) phosphorescent probe for selective detection of hypochlorite in live cells and in vivo”,Biomaterials, 53 (2015) 285-295.
19. Pingyu Zhang†, Jinquan Wang† (†equal contributors), Huaiyi Huang, Hongmin Chen, Ruilin Guan, Yu Chen, Liangnian Ji, Hui Chao*, “RuNH2@AuNPs as two-photon luminescent probes for thiols in living cells and tissues”,Biomaterials, 35 (2014) 9003-9011.
20. Yu Chen†, Liping Qiao† (†equal contributors), Liangnian Ji, Hui Chao*, “Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking”,Biomaterials, 35 (2014) 2-13.
21. Kangqiang Qiu, Jinquan Wang, Cuilan Song, Lili Wang, Hongyi Zhu, Huaiyi Huang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Crossfire for two-photon photodynamic therapy with fluorinated ruthenium(II) photosensitizers”,ACS Appl. Mater. Interfaces, 9 (2017) 18482-18492.
22. Kangqiang Qiu, Huaiyi Huang, Bingyang Liu, Yukang Liu, Ziyi Huang, Yu Chen, Liangnian Ji, Hui Chao*, "Long-Term Lysosomes Tracking with A Water-Soluble Two-Photon Phosphorescent Iridium(III) Complex",ACS Appl. Mater. Interfaces, 8 (2016) 12702-12710.
23. Pingyu Zhang, Huaiyi Huang, Juanjuan Huang, Hongmin Chen, Jinquan Wang, Kangqiang Qiu, Donglei Zhao, Liangnian Ji, Hui Chao*, “Non-Covalent Ruthenium(II) Complexes–Single Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation”,ACS Appl. Mater. Interfaces, 7 (2015) 23278-23290.
24. Cheng Ouyang,Lei Chen, Thomas W. Rees, Yu Chen* Jiankang Liu, Liangnian Ji, Jiangang Long*, Hui Chao*, “A mitochondria-targeting hetero-binuclear Ir(III)-Pt(II) complex induces necrosis in cisplatin-resistant tumor cells”,Chem. Commun., 2018, DOI: 10.1039/C8CC02795A.
25. Kangqiang Qiu†, Libing Ke† (†equal contributors), Xuepeng Zhang, Yukang Liu, Thomas W. Rees, Liangnian Ji, Jiajie Diao*, Hui Chao*, “Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(III) complexes”,Chem. Commun., 54 (2018) 2421-2424.
26. Pingyu Zhang*, Yi Wang, Kangqiang Qiu, Zhiqian Zhao, Rentao Hu, Chuanxin He, Qianling Zhang*, Hui Chao*, “NIR phosphorescent osmium(II) complex as lysosome tracking reagent andphotodynamictherapeutics”,Chem. Commun., 53 (2017) 12341-12344.
27. Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji, Hui Chao*, “Rational design of NIR-emitting iridium(III) complexes for multimodal phosphorescence imaging of mitochondria under two-photon excitation”,Chem. Commun., 53 (2017) 10374-10377.
28. Jiangping Liu, Chengzhi Jin, Bo Yuan, Yu Chen, Xingguo Liu, Liangnian Ji, Hui Chao*, “Enhanced cancer therapy by marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes”,Chem. Commun., 53 (2017) 9878-9881.
29. Jiangping Liu†, Chengzhi Jin† (†equal contributors), Bo Yuan, Xingguo Liu, Yu Chen, Liangnian Ji, Hui Chao*, “Selectively Lighting Up Two-Photon Photodynamic Activity in Mitochondria with AIE-Active Iridium(III) Complexes”,Chem. Commun., 53 (2017) 2052-2055.
30. Leli Zeng†, Shi Kuang† (†equal contributors), Guanying Li, Chengzhi Jin, Liangnian Ji, Hui Chao*, “A GSH-activatableruthenium(II)-azo photosensitizerfor two-photon photodynamic therapy”,Chem. Commun., 53 (2017) 1977-1980.
31.Bole Yu,Ying Chen,Mei Hong,Pingping Duan,Shifeng Gan,Hui Chao*,Zujin Zhao*,Jing Zhao*, "Rhodium-catalyzed C–H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties",Chem Commun., 51 (2015) 14365-14368.
32. Wenchao Xu, Jiarui Zuo, Lili Wang, Liangnian Ji, Hui Chao*, “Dinuclear ruthenium(II) polypyridyl complexes as single and two-photon luminescence cellular imaging probes”,Chem. Commun., 50 (2014) 2123-2125.
33. Yu Chen†, Liping Qiao† (†equal contributors), Bole Yu, Guanying Li,Chunyuan Liu,Liangnian Ji, Hui Chao*, “Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(III) complex”,Chem. Commun., 49 (2013) 11095-11097.
34. Guanying Li, Yu Chen, Jingheng Wu, Liangnian Ji, Hui Chao*, “Thiol-specific phosphorescent imaging in living cells with an azobis(2,2¢-bipyridine)-bridged dinuclear iridium(III) complex”,Chem. Commun., 49 (2013) 2040-2042.
35. Bole Yu, Yu Chen, Cheng Ouyang, Huaiyi Huang, Liangnian Ji, Hui Chao*, “A luminescent tetranuclear ruthenium(II) complex as atracking non-viral gene vector”,Chem. Commun., 49 (2013) 810-812.
36. Guo-Liang Liao, Xiang Chen, Liang-Nian Ji, Hui Chao*, “Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex”,Chem. Commun., 48 (2012) 10781-10783.
37. Huaiyi Huang, Pingyu Zhang, Bole Yu, Yu Chen, Jinquan Wang, Liangnian Ji and Hui Chao*, "Targeting Nucleus DNA with a Cyclometalated Dipyridophenazine Ruthenium(II) Complex",J. Med. Chem., 57 (2014) 8971-8983.(Highlight as Highly Cited Article of 2014 of J Med Chem)
38. Xiaoda Song, Yong Qian, Rong Ben, Xiang Lu, Hai-Liang Zhu*, Hui Chao* and Jing Zhao*, “Activation of C−H bonds in nitrones leads to iridium hydrides with antitumor activity”,J. Med. Chem., 56 (2013) 6531-6535.
39. Shanshan Zou, Guanying Li, Thomas W. Rees, Chengzhi Jin, Juanjuan Huang, Yu Chen, Liangnian Ji, Hui Chao*, “Interfering DNA high-order structures with chiral ruthenium(II) complexes”,Chem. Eur. J.,24 (2018) 690-698.
40. Jeannine Hess†, Huaiyi Huang† (†equal contributors),Adrian Kaiser, Vanessa Pierroz, Olivier Blacque, Hui Chao*, Gilles Gasser*, "Evaluation of the medicinal potential of two ruthenium(II) polypyridine complexes as one- and two-photon photodynamic therapy photosensitizers",Chem. Eur. J.,23 (2017) 9888-9896.(VIP Article, Highlight on ChemistryViews “Fighting Cancer with Ruthenium Complexes”)
41. Lingli Sun, Yu Chen, Shi Kuang, Guanying Li, Ruilin Guan, Jiangping Liu, Liangnian Ji, Hui Chao*, “Iridium(III) Anthraquinone Complexes asTwo-photon Phosphorescence Probes for Mitochondria Imaging and Tracking under Hypoxia”,Chem. Eur. J., 22 (2016) 8955-8965.(Hot paper).
42. Leli Zeng, Yu Chen, Huaiyi Huang, Jinquan Wang, Donglei Zhao, Liangnian Ji, Hui Chao*, “Cyclometalated Ruthenium(II)Anthraquinone Complexes ExhibitStrong Anticancer Activity inHypoxic Tumor Cells”,Chem. Eur. J., 21 (2015) 15308-15319. (Hot paper, Highlight on ChemistryViews “Combating Drug Resistance in Hypoxic Tumor Cells”)
43. Chengzhi Jin, Jiangping Liu, Yu Chen, Leli Zeng, Ruilin Guan, Cheng Ouyang, Liangnian Ji, Hui Chao*, “Cyclometalated Iridium(III) Complexes as Two-Photon Phosphorescent Probes for Specific Mitochondrial Dynamics Tracking in Living Cells”,Chem. Eur. J. 21 (2015) 12000-12010.(Highlight as Frontispiece)
44. Li Xu†, Xiang Chen† (†equal contributors), Jingheng Wu, Jinquan Wang, Liangnian Ji, Hui Chao*, “Dinuclear Ruthenium(II) Complexes that Induce and Stabilize G-quadruplex DNA”,Chem. Eur. J., 21 (2015) 4008-4020.
45. Bole Yu, Cheng Ouyang, Kangqiang Qiu, Jing Zhao, Liangnian Ji, Hui Chao*, “Lipophilic Tetranuclear Ruthenium(II) Complexes asTwo-Photon Luminescent Tracking Non-Viral Gene Vectors”,Chem. Eur. J., 21 (2015) 3691-3700.
46. Huaiyi Huang, Pingyu Zhang, Hongmin Chen, Liangnian Ji, Hui Chao*, “A Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities on 2D and 3D Cancer Models”,Chem. Eur. J., 21 (2015) 715-725.
47. Pingyu Zhang†,Lingmin Pei†, Yu Chen† (†equal contributors), Wenchao Xu, Qitian Lin, Jinquan Wang, Jingheng Wu, Yong Shen, Liangnian Ji and Hui Chao*, “A dinuclear ruthenium(II) complex as a one- and two-photon luminescent probe for biological Cu2+detection”,Chem. Eur. J., 19 (2013) 15494-15503.(Highlight as Frontispiece)
相關成果
先後在《Chem.Soc. Rev》、《Coord.Chem. Rev》、《PNAS》、《Angew. Chem. Int. Ed.》、《Chem. Sci.》、《Biomaterials》、《ACS Appl. Mater. Interfaces》、《Chem. Commun.》、《J. Med. Chem.》、《Chem. Eur. J》等國際期刊發表第一作者或通訊作者SCI論文163篇，論文被引用4600多次。參編著作 “Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine” (德國 John Wiley & Son出版公司出版, 2005年)和“生物無機化學導論”（第三版）（科學出版社，2010年）。申請中國發明專利16件, 授權12件。目前擔任中國化學會化學生物學專業委員會委員、《Scientific Reports》編委、《Journal of Inorganic Biochemistry》編委、《大學化學》編委。
獲獎情況
2001年獲中國高校自然科學獎二等獎（第九完成人）
2005年獲中國化學會“青年化學獎”
2006年入選教育部“新世紀優秀人才支持計畫”
2006年入選廣東省高等學校“千百十工程”人才培養計畫（校級）
2007年獲 中山大學化學與化工學院“53獎教金”
2011年獲廣東省科學技術獎一等獎（第二完成人）
2011年被評為中山大學校級教學名師
2012年獲國家自然科學獎二等獎（第三完成人）
2012年獲中山大學第七屆校級教學成果獎一等獎（第一完成人）
2012年獲中山大學第七屆校級教學成果獎一等獎（第四完成人）
2012年被評為南粵優秀教師（廣東省）
2013年獲中山大學化學與化工學院“芙蘭勵教獎”
2014年獲廣東省教育教學成果獎（高等教育）一等獎（第一完成人）
2014年獲廣東省教育教學成果獎（高等教育）二等獎（第四完成人）
2014年獲中山大學化學與化工學院“施開良教學管理創新獎”
2014年獲寶鋼優秀教師獎
2015年獲“國家傑出青年科學基金”
2016年入選廣東特支計畫“百千萬工程領軍人才”
2017年獲中山大學第八屆校級教學成果獎二等獎（第一完成人）
2017年獲中山大學第八屆校級教學成果獎一等獎（第五完成人）
2017年獲廣東省教育教學成果獎（高等教育）一等獎（第五完成人）
