尹燁,華大基因CEO。哥本哈根大學博士,基因組學研究員,大連理工大學兼職教授,第三屆中國人類遺傳資源管理專家組成員,中國計量測試學會生物計量專業委員會委員,深圳市標準化協會第七屆理事會會長,第四批國家“萬人計畫”科技創業領軍人才。
他熱愛生命科學,做研究、發論文、惜人才、重團隊,曾任華大科技總裁、華大集團營運長(COO)、華大醫學總裁。
他是“非典”科研攻關主要參與者之一,曾當選最年輕的中國傑出質量人、華大基因全球化布局推動者、華大基因收購CG項目核心成員、率領華大基因成功登入創業板。
2018年1月,他在JP Morgan會議上率先發布個人全基因組測序正式進入百元美金時代、同時發布解密所有5000種哺乳動物基因組的“生命周期表計畫”。
他心繫公益事業,組建面向罕見病群體的機構“同病相聯”,和團隊一起成立救助遺傳病的“華基金”“光基金”,帶領團隊發起多項罕見病救助計畫,並主導“科技援藏暨超低溫冰櫃運送活動”。
他是媒體圈、財經圈、科研圈最受歡迎的生物界“名嘴”,也是傳播生命科學的科普工作者。開設“天方燁談”電台節目,受邀出席WIRED、TEDx、一席、中國企業家論壇等媒體活動,為講述大眾“聽得懂的生命科學”。
基本介紹
- 中文名:尹燁
- 國籍:中國
- 民族:滿族
- 出生地:遼寧丹東(籍貫山東煙臺)
- 出生日期:1979年
人物經歷
公益實踐
獲獎記錄
主要論文
- Wang X, Wang H, Wang J,…, Yin Y…, Brassica rapa Genome Sequencing Project Consortium. (2011) The genome of the mesopolyploid crop species Brassica rapa. Nature Genetics. 2011 Aug 28;43(10):1035-9.
- 岳桂東,高強,羅龍海,王軍一,許嬌卉,尹燁(2012) 高通量測序技術在動植物研究領域中的套用.中國科學,42(2): 107-124.
- Gao Q, Yue GD, Li WQ, Wang JY, Xu JH, Yin Y. (2012) Recent progress using high-throughput sequencing technologies in plant molecular breeding. Journal of Integrative Plant Biology, 54(4):215-27.
- Qiu Q, Zhang G, Ma T,…, Yin Y, ….(2012) The yak genome and adaptation to life at high altitude. Nature Genetics. 2012 Jul 1;44(8):946-9.
- Kunbo Wang, Zhiwen Wang, Fuguang Li, …, Ye Yin,…. (2012) The draft genome of a diploid cotton Gossypium raimondii. Nature Genetics. 2012 Aug 26; 44(10):1098–1103
- Zhang G, Fang X, Guo X, …, Yin Y, Wang J. (2012) The oyster genome reveals stress adaptation and complexity of shell formation.Nature. 2012 Oct 4;490(7418):49-54.
- David M Altshuler, Richard M Durbin, Goncalo R Abecasis...Yin Y...(2012)An integrated map of genetic variation from 1,092 human genomes. Nature. 2012 November 1; 491(7422): 56–65.
- Shaogui Guo, Jianguo Zhang, Honghe Sun, …, Ye Yin, ….(2012) The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nature Genetics. 2012 Nov 25; 45(1):51–58
- Yin Y, Yue GD, Gao Q, Wang ZY,... (2012) Genome Sequence of Pedobacter arcticus sp. nov., a Sea Ice Bacterium Isolated from Tundra Soil. Journal of Bacteriology, 2012 Dec;194 (23):6688.
- Qixiang Zhang, Wenbin Chen, Lidan Sun, …,Ye Yin, …(2012) The genome of Prunus mume.Nature Communications, 2012,DOI: 10.1038/ncomms2290
- Xiangjiang Zhan, Shengkai Pan, Junyi Wang, …, Ye Yin, …(2013) Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle.Nature Genetics. 2013 March 24;45(5): 563–566
- Zhuo Wang, Juan Pascual-Anaya, Amonida Zadissa,…, Ye Yin, Bronwen Aken, Guojie Zhang& Naoki Irie.(2013) The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan. Nature Genetics. 2013 April28;10.1038/ng.2615
- Jinfeng Chen, Quanfei Huang, Dongying Gao...Ye Yin...(2013)Whole-genome sequencing of Oryza brachyantha reveals mechanisms underlying Oryza genome evolution. Nature Communications, 2013, DOI: 10.1038/ncomms2596
- Yabin Chen, Qingyan Zhang,Tao Shen … ,Ye Yin, …. (2013)Comprehensive mutation analysis by whole-exome sequencing in 41 Chinese families with Leber congenital amaurosisInvest . Ophthalmol Vis Sci. 2013 May 9(共同作者)
- Huang L1, Zhang Q, Li S, Guan L, Xiao X, Zhang J, Jia X, Sun W, Zhu Z, Gao Y, Yin Y, Wang P, Guo X, Wang J, Zhang Q.(2013) Exome sequencing of 47 chinese families with cone-rod dystrophy: mutations in 25 known causative genes. PLoS One. 2013 Jun 11; 8(6):e65546.
- Xiaosen Guo, Max Brenner, Xuemei Zhang, ..., Ye Yin, ... (2013) Whole-Genome Sequences of DA and F344 Rats with Different Susceptibilities to Arthritis,Autoimmunity, Inflammation and Cancer. Genetics, August 2013, 194(4):1017-28
- Zhang C1, Li D, Zhang J,..., Yin Y, ....(2013)Mutations in ABCB6 cause dyschromatosis universalis hereditaria. J Invest Dermatol. 2013 Sep;133(9):2221-8.
- Tao Ma,Junyi Wang,Gongke Zhou, … ,Ye Yin, …(2013) Genomic insights into salt adaptation in a desert poplar. Nature Communications,2013, doi:10.1038/ncomms3797.
- Xiao JH, Yue Z, Jia LY, ..., Yin Y...(2013)Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome Biology,2013,14:R141 doi:10.1186
- Cheng Qin, Changshui Yu, Yaou Shen, …, Ye Yin, Jiping Yu, Kailin Hu, and Zhiming Zhang.(2014) Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization. PANS, 2014,doi/10.1073/pnas.1400975111
- Udpa N, Ronen R, Zhou D,..., Yin Y...(2014)Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biology. 2014 Feb 20;15(2):R36.
- Shiqiang Li, Liping Guan, Shaohua Fang, ..., Ye Yin, ...(2014) Exome sequencing reveals CHM mutations in six families with atypical choroideremia initially diagnosed as retinitis pigmentosa. International Journal of Molecular Medicine,2014 June 6, DOI: 10.3892
- Xu Y1, Guan L, Shen T, ..., Yin Y, Guo X, Wang J, Zhang Q.(2014) Mutations of 60 known causative genes in 157 families with retinitis pigmentosa based on exome sequencing. Hum Genet. 2014 Jun 18.
- Su Z, Labaj PP, Li S, ..., Yin Y, ... (2014) A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature Biotechnology. 2014 Sep; 32(9):903-14.
- Huiguang Wu, Xuanmin Guang, Mohamed B. Al-Fageeh...Ye Yin,...(2014)Camelid genomes reveal evolution and adaptation to desert environments. Nature Communications. 21 October 2014, doi:10.1038/ncomms6188.
- Haihua Bai, Xiaoshen Guo, Dong Zhang, ... Ye Yin,...(2014)The genome of a mongolian individual reveals the genetic imprints of mongolians on modern human populations.Genome Biology and Evolution. 5 November 2014, 6(12):3122-3136
- Xiangyu Ma, Liping Guan, Wei Wu,...Ye Yin, ...(2015) Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa. Scientific Report. 2015 Mar 18;5:9236. doi: 10.1038/srep09236.
- Zhang H1, Gao Y, Jiang F,...Yin Y,...(2015)Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146 958 pregnancies. Ultrasound Obstet Gynecol. 2015; 45: 530–538.Published online 8 April 2015 in Wiley Online Library . DOI:10.1002/uog.14792.
- W J, Wen J, Li J,...Yin Y,...(2003) Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus. Clinical Chemistry. 2003 Dec;49(12):1989-96.
- Khurana E, Fu Y, Colonna V,...Yin Y,... (2013) Integrative annotation of variants from 1092 humans: application to cancer genomics. Science. 2013 Oct 4;342(6154):1235587. doi: 10.1126/science.1235587.
- Yu X, Jin T, Cui Y,...Yin Y,... (2014) Influenza H7N9 and H9N2 viruses: coexistence in poultry linked to human H7N9 infection and genome characteristics. Journal of Virology. 2014 Mar;88(6):3423-31. doi: 10.1128/JVI.02059-13. Epub 2014 Jan 8.
- Huerta-Sánchez E, Jin X, Asan,...Yin Y,... (2013) Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 2014 Aug 14;512(7513):194-7. doi: 10.1038/nature13408. Epub 2014 Jul 2.
- Cai N, Chang S, Li Y1,...Yin Y,... (2015) Molecular signatures of major depression. Current Biology.2015 May 4;25(9):1146-56. doi: 10.1016/j.cub.2015.03.008. Epub 2015 Apr 23.
- Bäckhed F, Roswall J, Peng Y,...Yin Y,... (2015) Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. Cell Host Microbe. 2015 May 13;17(5):690-703. doi: 10.1016/j.chom.2015.04.004.
- Xu Y, Guan L, Xiao X,...Yin Y,... (2015) Mutation analysis in 129 genes associated with other forms of retinal dystrophy in 157 families with retinitis pigmentosa based on exome sequencing. Molecular Vision. 2015 Apr 28;21:477-86. eCollection 2015.
- Xu Y, Guan L, Xiao X,...Yin Y,... (2015) ALMS1 null mutations: a common cause of Leber congenital amaurosis and early-onset severe cone-rod dystrophy. Clinical Genetics. 2015 May 22. doi: 10.1111/cge.12617.
- Zhang W, Yu Y, Hertwig F,...Yin Y,... (2015)Comparison of RNA-seq and microarray-based models for clinical endpoint prediction.Genome Biology. 2015 Jun 25;16:133. doi: 10.1186/s13059-015-0694-1.
- Li J, Gao B, Guan L,...Yin Y,... (2015) Unique Variants in OPN1LW Cause Both Syndromic and Nonsyndromic X-Linked High Myopia Mapped to MYP1. Investigative Ophthalmology & Visual Science. 2015 Jun;56(6):4150-5. doi: 10.1167/iovs.14-16356.
- Cai N, Bigdeli TB, Kretzschmar W,...Yin Y,... (2015) Sparse whole-genome sequencing identifies two loci for major depressive disorder.Nature. 2015 Jul 30;523(7562):588-91. doi: 10.1038/nature14659. Epub 2015 Jul 15.
- Zhang X, Zhang D, Jia H,...Yin Y,... (2015) The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment.Nature Medicine.2015 Aug;21(8):895-905. doi: 10.1038/nm.3914. Epub 2015 Jul 27.
- 1000 Genomes Project Consortium, Auton A, Brooks LD... (2015) A global reference for human genetic variation. Nature. 2015 Oct 1;526(7571):68-74. doi: 10.1038/nature15393.
- Sudmant PH, Rausch T, Gardner EJ,...Yin Y,... (2015)An integrated map of structural variation in 2,504 human genomes. Nature. 2015 Oct 1;526(7571):75-81. doi: 10.1038/nature15394.
- Li C, Gao Z, Li F, Li X,...Yin Y,... (2015) Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma.Scientific Reports.2015 Oct 27;5:14237. doi: 10.1038/srep14237.
- Xu Y1, Guan L, Xiao X,...Yin Y,... (2015) Identification of MFRP Mutations in Chinese Families with High Hyperopia. Optometry & Vision Science.2016 Jan;93(1):19-26. doi: 10.1097/OPX.0000000000000751.
- Delaneau O, Marchini J; 1000 Genomes Project Consortium.(2014) Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.Nature Communications.2014 Jun 13;5:3934. doi: 10.1038/ncomms4934.
- Colonna V, Ayub Q, Chen Y,...1000 Genomes Project Consortium,... (2014) Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.Genome Biology.2014 Jun 30;15(6):R88. doi: 10.1186/gb-2014-15-6-r88.
- Jun Wang,Lachlan J.M. Coin,Lin Fang,...,Ye Yin,...(2016)Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences. Nature Genetics.10.1038/ng.3559.
- 黃輝,陳冬娜,吳靜,尹燁(2016)高通量測序技術在罕見病分子診療中的套用及臨床實例分析,藥學進展.40(6):420-428.
- Jingmei Ma,Yicong Wang,Weipeng Wang,...,Ye Yin,...(2016)Validation of combinatorial probe-anchor ligation (cPAL) based sequencing method for non-invasive prenatal testing in trisomy detection by a central laboratory.Ultrasound in Obstetrics & Gynecology. 10.1002/uog.16010.
- Wen Xie,Chunhai Chen,Zezhong Yang,...,Ye Yin,...(2017)Genome sequencing of the sweetpotato whitefly Bemsia tabaci MED/Q.Giga Science. 10.1093/gigascience/gix018.
- YuLing Lin,JiuMeng Min,RuiLian Lai,...,Ye Yin,...(2017)Genome-wide sequencing of longan (Dimocarpus longan Lour.) provides insights into molecular basis of its polyphenol-rich characteristics.Giga Science.10.1093/gigascience/gix023.
- Yuanyuan Li,Miki Ohira,Yong Zhou,...,Ye Yin,...(2017)Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway.Oncotarget. 10.18632/oncotarget.18079.
- Alex Harkess, Jinsong Zhou, Chunyan Xu, ...,Ye Yin,...(2017)The asparagus genome sheds light on the origin and evolution of a young Y chromosome.Nature Communications.10.1038/s41467-017-01064-8.
- Xuan Shang,Zhiyu Peng,Yuhua Ye,...,YeYin,(2017)Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies.EBioMedicine.10.1016/j.ebiom.2017.08.015.
- Yueqiang Wang,Yue Shen,Ying Gu,Shida Zhu,Ye Yin. (2018) Genome Writing Current Progress and Related Applications.Genomics Proteomics & Bioinformatics. 10.1016/j.gpb.2018.02.001.
- Linhuan Wu, Kevin McCluskey, Philippe Desmeth, ..., Ye Yin, ... (2018) The Global Catalogue of Microorganisms 10K type strain sequencing project.GigaScience. 10.1093/gigascience/giy026.
- Chaoling Wei, Hua Yang, Songbo Wang,..., Ye Yin, ... (2018)Draft genome sequence of Camellia sinensis var. sinensis provides insights into the evolution of the tea genome and tea quality. Proceedings of the National Academy of Sciences of the United States of America. 10.1073/pnas.1719622115.
- Wensheng Wang, Ramil Mauleon, Zhiqiang Hu, ..., Ye Yin, ...(2018) Genomic variation in 3010 diverse accessions of Asian cultivated rice. Nature.10.1038/s41586-018-0063-9.
- Mingzhi Ye, Shiyong Li, Weizhe Huang,..., Ye Yin, ... (2018)Comprehensive targeted super-deep next generation sequencing enhances differential diagnosis of solitary pulmonary nodules.Journal of thoracic disease.10.21037/jtd.2018.04.09.