宋海峰，男，博士，研究員，研究生導師。
基本介紹
- 中文名：宋海峰
- 國籍：中國
- 性別：男
- 職稱：軍事醫學科學院研究員
簡介,代表性論文,專著,
簡介
軍事醫學科學院放射與輻射醫學研究所藥理毒理研究室副主任，軍事醫學科學院藥物代謝重點實驗室副主任，放射與輻射醫學研究所生物技術藥物代謝實驗室主任。兼任國家新藥審評中心CDE新藥審評專家、軍隊新藥審評專家。APS，《中國藥理學與毒理學雜誌》、《中國新藥雜誌》、《軍事醫學科學院院刊》等雜誌審稿專家。國家自然科學基金以及國家863項目審評人。ABO聯盟技術委員會執委。
長期從事生物技術藥物藥理學、藥代動力學研究。先後承擔“十一五國家重大新藥創製專項項目”2項、“十一五軍隊特需藥保密專項”1項、國家“863”重大專項課題1項、國家自然科學基金重點項目1項、面上項目基金7項、軍隊指令性課題2項。承擔新藥研究橫向合作項目70餘項。
國內外核心期刊發表各類論文60餘篇，被SCI收錄20餘篇。累計影響因子超過30，主要論文被引用次數累計超過40。獲國家發明專利3項，編寫生物技術藥物專著兩部。培養碩士研究生25人，協助培養博士生10人。
代表性論文
Song HF, Liu XW, Tang ZM. Pharmacokinetics and peripheral platelet counts after single dose of recombinant human thrombopoietin in rhesus monkeys. Acta Pharmacol Sin 1999; 20（3）: 244-8.
Song HF，Tang ZM，Yuan SJ，Zhu BZ．Application of secondary structure prediction in antisense drug design targeting protein kinase C-a mRNA and QSAR analysis．Acta Pharmacol Sin， 2000；21（1）：80-6．
Yang SP, Song ST, Song HF. Antisense oligonucleotides, a new class of drug for breast cancer therapy. J Tumor Marker Oncology 2001; 16: 361-2.
Liu XW, Song HF, Tang ZM, Zhao K, Zhu BZ, Wang LP, Zhang Y. Pharmacokinetics and partial thromboplastin time after intravenous recombinant hirudin variant-2 in rhesus monkeys. Acta Pharmacol Sin 2002; 23（9）: 842-6.
Song HF, Liu XW, ang ZM, Zhu BZ, Wang LP, Wang SH, Zhang Y. Systemic absorption and bioavailability of recombinant human PDGF-BB after application on full-thickness ulcers in Rhesus monkeys. Asian Journal of drug Metabolism and Pharmacokinetics 2003; 3（2）: 154-158.
Song HF, Tang ZM, Yuan SJ, Zhu BZ, Liu XW. Antisense candidates against protein kinase C-a designed based on phylogenesis and simulant structure of mRNA. Acta Pharmacol Sin， 2003；24（3）：269-276．
Yang SP, Song ST, Tang ZM, Song HF. Optimization of antisense drug design against conservative local motif in stimulant secondary structures of HER-2 mRNA and QSAR analysis. Acta Pharmacol Sin, 2003；24(9): 897-902.
Yang SP, Song ST, Song HF. Advancements of antisense oligonucleotides in treatment of breast cancer. Acta Pharmacl Sin. 2003,24(4): 289-295.
Shang MM, Liu WL, Tang ZM, Song HF. Separation of oligonucleotides by non-gel sieving capillary electrophoresis. Asian Journal of drug Metabolism and Pharmacokinetics 2003; 3（2）: 159-163.
Liu XW, Tang ZM, Song HF, Dou GF. Metabolism, distribution, and excretion of recombinant human thrombopoietin in mice. Asian Journal of drug Metabolism and Pharmacokinetics 2003; 3（3）:190-194.
Shang MM, Liu XW, Tang ZM, Song HF. Separation of oligonucleotids by non-gel sieving capillary elelctropherosis. Asian Journal of drug Metabolism and Pharmcokinetics. 2003, 3（2）:151-155
Shang MM, Song HF, Liu XW, Tang ZM. Detection and quantitation of PS20, a phosphorothioate oligodeoxynucleotides in monkey plasma. Acta Pharmacol Sin 2004; 25（6）: 801-6.
Liu XW, Song HF, Zhu BZ, Yu G, Bai J, Shang MM, Tang ZM. Metabolism, distribution and excretion of recombinant human glucagons-like peptide-1 （7-36） in rats. Acta Pharmacol Sin 2004; 25（11）: 1540.
Shang MM, Song HF, Tang ZM, Liu XW, Chen HP. Evaluation of cellular delivery of phosphorothioate oligonucleotides targeting Her-2 mRNA in breast cancer cell line. Acta Pharmacol Sin 2004; 25（11）: 1538.
Dai SJ, Liu XW, Song HF, Zhu BZ. Pharmacokinetic profiles of recombinant human parathyroid
hormone （1-34） after subcutaneous injection in rats. Acta Pharmacologica Sinica 2004, 25（11）: 1563.
Song HF, Liu XW, Zhu BZ, Yu G, Bai J, Shang MM, Tang ZM. Pharmacokinetic profile of rhGLP-1（7-36） in rhesus monkeys. Acta Pharmacol Sin 2004, 25（11）: 1563.
Bai J, Song HF, Liu XW, Zhu BZ, Ou L, Sun X, Miao XJ. Biodistribution profiles of recombinant anti- breast cancer immunotherapy infusion protein HSP-MUC1 vaccine after subcutaneous in tumor-bearing mice. Acta Pharmacol Sin 2004, 25（11）: 1550.
Song HF，Liu XW，Zhang HN, Zhu BZ, Yuan SJ, Liu SY, Tang ZM. Pharmacokinetics of His-tag recombinant human endostatin in Rhesus monkeys. Acta Pharmacologica Sinica 2005 Jan; 26 （1）: 124-8.
Dai SJ, Song HF, Dou GF, Qian XH, Zhang YJ, Cai Y, Liu XW, Tang ZM. Quantification of sifuvirtide in monkey plasma by an on-line solid-phase extraction procedure combined with liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom 2005; 19:1273-82.
Dai SJ, Dou GF, Qian XH, Song HF, Tang ZM, Liu DS, Liu XW, Meng YL, Tang ZM, Liang Q. Pharmacokinetics of sifuvirtide, a novel anti-HIV-1 peptide, in monkeys and the comparison with inhibitory concentrations in vitro. Acta Pharmacol Sin 2005; 26（10）: 1274-80.
Du HY, Xia SY, Song HF, Li N, Shang MM, Zou J, Wang QQ, Ou L, Sun X, Ji AG, Tang ZM. , Structure-efficacy relationships of immunostimulatory activity of CpG-containing oligodeoxynucleotides on mouse spleen cells. Acta Pharmacologica Sinica, 2007, 28 （10）: 1637-44.
Wang QQ, Li XS, Dai SJ, Ou L, Sun X, Zhu BZ, Chen F, Shang MM, Song HF. Quantification of puerarin in plasma by on-line solid phase extraction column switching liquid chromatography-tandem mass spectrometry and its applications to a pharmacokinetic study. Journal of chromatography B, 2008, 863 （1）: 55-64.
Fu J, Li D, Xia SY, Song HF, Dong ZX, Chen F, Sun X, Tang ZM. Absolute quantification of plasmid DNA by real-time PCR with genomic DNA as external standard and its application to biodistribution study of a HIV DNA vaccine. Analytical Science, 2009
Fu J, Tang ZM, Gao X, Zhao F, Zhong H, Wen MR, Sun X, Song HF, Qian XH. Optimal design and validation of antiviral siRNA for targeting HBV. Acta Pharmacologica Sinica, 2009
專著
湯仲明主編，劉秀文、宋海峰副主編，《生物技術藥物藥代動力學》，化學工業出版社，2004。
宋海峰主譯，湯仲明主審，《生物製藥：生物化學與生物技術》，化學工業出版社，2006。
