夏恆傳，男，博士，江蘇大學生命科學研究院副研究員，碩士研究生導師。
基本介紹
- 中文名：夏恆傳
- 學位/學歷：博士
- 職業：教師
- 專業方向：蛋白質的分離、鑑定、結構、功能與相互作用的研究
- 任職院校：江蘇大學生命科學研究院
個人經歷,研究方向,學術成果,
個人經歷
1993 -1997年於曲阜師範大學生物系讀本科，1997- 2004年於中國科學院上海生物化學與細胞生物學研究所碩博連讀，2004-2008年於美國密西根大學讀博士後，2008年-至今於江蘇大學生命科學研究院工作。
研究方向
主要從事蛋白質的分離、鑑定、結構、功能與相互作用的研究。目前重點研究家蠶生長發育的調控機制、家蠶與家蠶核型多角體病毒BmNPV相互博弈的機制。
學術成果
研究課題：
1. 家蠶蛋白BVta1在MVB途徑及桿狀病毒BmNPV感染中的作用機制研究，國自然，31372259，201401-201712，主持。
2. 家蠶β-N-乙醯氨基葡萄糖苷酶2對核型多角體病毒蛋白糖基化的影響，國自然，31101673，201201-201412，參與，排名第2。
3. 家蠶胺基酸轉運蛋白與其抗BmNPV功能的研究， 國自然，31301919， 201401-201612，參與，排名第2。
4. 銅綠假單胞菌鐵載體pyoverdine的周質空間合成途徑中重要蛋白質的結構及功能研究，國自然，31170692，201201-201512，參與，排名第2。
5. 銅綠假單胞菌鐵載體合成途徑關鍵蛋白質的結構及功能研究，國家重點實驗室，M2008-07，200901-201012，主持。
6. 家蠶細胞MVB途徑及在DNA病毒BmNPV出芽中的作用機制研究，省高校自然基金，10KJB180001，201009-201212，主持。
發表論文：
1. Xia H, Chen L, Shao D, Liu X, Wang Q, Zhu F, Guo Z, Gao L, Chen K.Vacuolar protein sorting 4 is required for silkworm metamorphosis. Insect Mol Biol. 2019 Oct;28(5):728-738.
2. Wang Q, Ren M, Liu X, Xia H, Chen K. Peptidoglycan recognition proteins in insect immunity. Mol Immunol. 2019 Feb;106:69-76.
3. Xia H, Shao D, Liu X, Wang Q, Zhou Y, Chen K. Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development. J Insect Sci. 2017 May 1;17(3).
4. Chen L, Yang Y, Wang Y, Qiu L, Xia H, Wang A, Liu H, Shi H, Chen K. Proteomic Response of the Rat Liver in Differential Swimming Modes. Clin Exp Pharmacol Physiol. 2017 Dec 7. doi: 10.1111/1440-1681.12905.
5. Tang Q, Wu P, Hu Z, Yang Y, Qiu L, Liu H, Zhu S, Guo Z, Xia H, Chen K, Li G. Evidence for the role of BmNPV Bm65 protein in the repair of ultraviolet-induced DNA damage. J Invertebr Pathol. 2017 Oct;149:82-86.
6. Yuan Z, Gao F, Bai G, Xia H, Gu L, Xu S. Crystal structure of PvdO from Pseudomonas aeruginosa. Biochem Biophys Res Commun. 2017 Feb 26;484(1):195-201.
7. 邵丹丹, 夏恆傳, 陳波, 余毛毛，陳克平. 多功能分子機器 ESCRT 的研究進展. 江蘇大學學報（醫學版）, 2016(4).
8. Gao L, Li Q, Li R, Deng Z, Brady B, Xia N, Chen G, Zhou Y, Xia H, Chen K, Shi H. Protein determination using graphene oxide-aptamer modified gold nanoparticles in combination with Tween 80. Anal Chim Acta. 2016 Oct 19;941:80-86.
9. Han, Y., Xia, H., Tang, Q., Lu, P., Ma, S., Yang, Y., Shao, D., Ma, Q. and Chen, K. (2014) The Bombyx mori nucleopolyhedrovirus Bm111 affects virulence but not virus replication. Curr Microbiol 69: 56-62.
10. Ma, S., Kang, Z., Lu, P., Yang, Y., Yao, Q., Xia, H. and Chen, K. (2015) Molecular and Physiological Characterization of Two Novel Multirepeat beta-Thymosins from Silkworm, Bombyx mori. PLoS One 10: e0140182.
11. Lü P#, Xia H#, Gao L, Pan Y, Wang Y, Cheng X, Lü H, Lin F, Chen L, Yao Q, Liu X, Tang Q, Chen K. V-ATPase Is Involved in Silkworm Defense Response against Bombyx mori Nucleopolyhedrovirus. PLoS One. 2013 Jun 18;8(6):e64962. (# co-first author)
12. 夏恆傳，張春霞，馮凡，袁弋，周陽，劉曉勇，朱克明，姚勤，陳克平。多囊體生物發生和蛋白質分揀：ESCRT、Vps4、Ubiquitination一個都不能少. 生物化學與生物物理進展，2013, 40(2):103-117
13. Hengchuan Xia, Chunxia Zhang, Fan Feng, Yi Yuan, Xiaoyong Liu, Keming Zhu, Qin Yao, Keping Chen. The multivesicular body pathway: A newly discovered battlefield for gameplay between virus and host. African Journal of Microbiology Research, 2013, 7(11):913-920
14. Qin L#, Xia H#, Shi H, Zhou Y, Chen L, Yao Q, Liu X, Feng F, Yuan Y, Chen K. Comparative proteomic analysis reveals that caspase-1 and serine protease may be involved in silkworm resistance to Bombyx mori nuclear polyhedrosis virus. J Proteomics. 2012 Jun 27;75(12):3630-8.
15. Xia H, Zhang C, Feng F, Yuan Y, Zhou Y, Liu X, Zhu K, Yao Q, Chen K. Molecular cloning, expression and characterization of a novel vacuolar protein sorting 4 gene in silkworm, Bombyx mori. Mol Biol Rep. 2012 Dec;39(12):10339-46
16. Xia H, Wu C, Xu Q, Shi J, Feng F, Chen K, Yao Q, Wang Y, Wang L. Molecular cloning and characterization of lactate dehydrogenase gene 1 in the silkworm, Bombyx mori. Mol Biol Rep. 2011 Mar;38(3):1853-60
17. Hengchuan Xia, Honggang Lv Keping Chen, Qin Yao, Peng Lv, Jun Li, Huiqing Chen and Lin Wang.Cloning and characterization of peptidylprolyl isomerase B in the silkworm, Bombyx mori. African Journal of Biotechnology. 2009,8(24):7148-7155
18. Pan Y, Xia H, Lü P, Chen K, Yao Q, Chen H, Gao L, He Y, Wang L. Molecular cloning, expression and characterization of Bmserpin-2 gene from Bombyx mori.Acta Biochim Pol. 2009;56(4):671-7
19. Xiao J, Xia H, Zhou J, Azmi IF, Davies BA, Katzmann DJ, Xu Z. Structural basis of vta1 function in the multivesicular body sorting pathway. Dev Cell. 2008, 14(1): 37-49
20. Xiao J, Xia H, Yoshino-Koh K, Zhou J, Xu Z. Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J Mol Biol. 2007, 374(3): 655-70
21. Xia HC, Li F, Li Z, Zhang ZC. Purification and characterization of Moschatin, a novel type I ribosome-inactivating protein from the mature seeds of pumpkin (Cucurbita moschata), and preparation of its immunotoxin against human melanoma cells. Cell Research, 2003, 13 (5): 369-74
22. Xia HC, Hu WG, Yang XX, Li F, Zhang ZC. Preparation and primary application of monoclonal antibodies against a novel ribosome-inactivating protein Moschatin from pumpkin seeds. Acta Biochim Biophys Sin (Shanghai). 2004, 36 (2): 105-10.
