周紅剛,南開大學藥學院講師。
基本介紹
- 中文名:周紅剛
- 國籍:中國
- 民族:漢
- 性別:男
基本信息,個人經歷,代表作品,
基本信息
職稱:南開大學藥學院講師
學科方向:生物化學
個人經歷
2010畢業於英國雷丁大學(University of Reading, UK)藥學院藥理系,獲博士學位;研究的主要方向是與重點藥靶子G蛋白偶聯受體(GPCR)相關通路的分子藥物設計與篩選,包括運用分子生物學方法獲得高純度可溶性GPCR抑制蛋白,嘗試運用多種技術獲得底物與蛋白的結合證據及其結合力的測定,比如Pull down Assay, ITC, BIACore, MALDI, NMR 和CD等技術,再通過共結晶或者浸泡的方式獲得複合物晶體,通過結構解析得到其結構和結合信息,為藥物設計提供強有力的基礎。同時參與超級細菌NDM-1和藍藻FPR等多種蛋白的解析工作以及多種藥物篩選備選庫的組建工作。
代表作品
1) Guo Y, Wang J, Niu G, Shui W, Sun Y, Zhou H, Zhang Y, Yang C, Lou Z, Rao Z.A structural view of the antibiotic degradation enzyme NDM-1 from a superbug.Protein Cell. 2011 May;2(5):384-94. Epub 2011 Jun 2.
2) G. Cheng, C. Krasel, H. G. Zhou, D. Chappell, and I. W. Hamley. Genetic Expression of an Amyloid Peptide Fragment and Analysis of Formylated Products. Organic Letters. 2011,13(10), pp2572-2575.
3) Cheng Chen, Yanxin Wang, Honggang Zhou, Zheng Yin and Zihe Rao. Crystal Structure of EV71 RNA-Dependent RNA Polymerase in Complex with Its Protein Primer VPg: Implication for an in trans mechanism of EV71 replication complex.
4) Ting Liu, Yingli Shuai,Honggang Zhou. Purification, crystallization and preliminary X-ray diffraction of fluorescence recovery protein (FRP) from Synechocystis PCC 6803. (2011). Acta Crystallographica Section F.
5) Lihong Zhou, Jiejin Li, Roger George, Sandrine Ruchaud, Hong-Gang Zhou, John E. Ladbury, William C. Earnshaw and Xuemei Yuan.(2009). Effects of Full-Length Borealin on the Composition and Protein?Protein Interaction Activity of a Binary Chromosomal Passenger Complex. Biochemistry 48(6): 1156-1161
6) Jian Ming Wang,Hong Gang Zhou and Jun Xian Ren. (2002). The Research Method for Distillation of Aloe Amylose. Food Research and Development. 23(3): 21-24. ISSN 1005-6521