基本介紹
- 中文名：吳旭冬
- 畢業院校：復旦大學
- 職業：教師
人物經歷,代表論文,
人物經歷
2005-2009年就讀於復旦大學生命科學系並獲得本科學位。
2009-2014年在耶魯大學分子生物物理與生物化學攻讀博士學位。
2014年起在哈佛大學醫學院從事博士後研究工作，在Jane Coffin Childs醫學研究紀念基金會的支持下師從Dr.Tom A Rapoport進行內質網蛋白質穩態調控方向的研究。
2022年秋季全職加入西湖大學任助理教授/博士生導師一職。
代表論文
1. Feng P#, Wu X, Erramilli SK, Paulo JA, Knejski P, Gygi SP, Kossiakoff AA, Rapoport TA#. A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel. Nature. 2022 Jul;607(7918):374-380.
2. Wu X#, Rapoport TA#. Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies). PNAS. 2021 Oct 12;118(41): e2115001118.
3. Wu X, Siggel M, Ovchinnikov S, Mi W, Svetlov V, Nudler E, Liao M, Hummer G, Rapoport TA#. Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex. Science. 2020 Apr 24;368 (6489):eaaz2449. doi: 10.1126/science.aaz2449.
4. Wu X, Cabanos C, Rapoport TA#. Structure of the post-translational protein translocation machinery of the ER membrane. Nature. 2019 Feb;566 (7742):136-139.
5. Baskin JM*, Wu X*, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM#, De Camilli P#. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat Cell Biol. 2016 Jan;18(1):132-8.
6. Wu X, Chi RJ, Baskin JM, Lucast L, Burd CG, De Camilli P, and Reinisch KM#. Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev Cell. 2014 Jan 13;28(1):19-29.
7. Schauder CM, Wu X, Saheki Y, Narayanaswamy P, Torta F, Wenk MR, De Camilli P#, Reinisch KM#. Structure of a lipid-bound Extended-Synaptotagmin indicates a role in lipid transfer. Nature. 2014 Jun 26;510(7506):552-5.
8. Wu X, Bradley MJ, Cai Y, Kümmel D, De La Cruz EM, Barr FA, Reinisch KM#. Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. PNAS. 2011 Nov 15; 108 (46):18672-7.
9. Wu X, Wu D, Lu Z, Chen W, Hu X, Ding Y#. A novel method for high-level production of TEV protease by superfolder GFP tag. J Biomed Biotechnol. 2009; 2009:591923.
10. Wu X, Rapoport TA#. Translocation of proteins through a distorted lipid bilayer. Trends Cell Biol. 2021 Jan 30;S0962-8924 (21) 00006-4. (Review)
11. Wu X, Rapoport TA#. Mechanistic insights into ER-associated protein degradation. Curr Opin Cell Biol. 2018 Aug; 53:22-28. (Review)
