史薇，女，博士，南京大學環境學院副教授。
基本介紹
- 中文名：史薇
- 畢業院校：南京大學
- 學位/學歷：博士
- 專業方向：理學
- 任職院校：南京大學
人物經歷,學習經歷,研究經歷,研究領域,科研項目,學術成果,發表論文,專利軟體,交流合作,
人物經歷
學習經歷
2007.9-2011.6 南京大學 環境化學，理學博士
2003.9-2007.6 南京大學 環境科學，理學學士
研究經歷
2014.6- 南京大學，環境學院，副教授
2015.8-2016.8， 美國University of California, Riverside，訪問學者
2011.8-2014.6 南京大學，環境學院，助理研究員
研究領域
1. 有機污染物在環境過程中的遷移、轉化與毒性效應
2. 內分泌干擾物的高通量篩選與風險評估
3. 複合污染介質中有機毒物分級鑑別與生物可利用性
科研項目
(1)國家自然科學基金面上項目，21577058，基於生物富集轉化過程及其仿生技術的水中抗雄激素活性物質鑑別評價研究，2016/01-2019/12，76萬元，在研，主持;
(2)國家環保部公益性行業科研專項，201409040，水體沉積物毒性鑑定與生物測試標準方法體系研究(子課題)，2014/01-2017/12，40萬，在研，參加;
(3)國家自然科學基金青年科學基金項目，21307054，基於生物可利用機制的沉積物中擬雄激素活性物質鑑別研究，2014/01-2016/12，26萬元，已結題，主持;
(4)江蘇省自然科學基金青年項目，BK20130551，沉積物擬雄激素活性評價及毒物鑑別技術研究，2013/07-2016/07，20萬元，已結題，主持;
(5)國家自然科學基金NSFC-TAMU合作項目， 21411120337，中美人群暴露於大氣顆粒污染物的毒性標誌物研究，2014/10-2015/09，5萬元，已結題，主持;
(6)國家高技術研究發展計畫(863計畫)“典型化工區化學品風險甄別與控制綜合示範”子課題，2013AA06A309，以效應為導向的關鍵致毒物質識別技術套用研究與示範，2013/01-2015/12， 150萬元，已結題，主持。
學術成果
發表論文
(1) Shi W, Yu N, Han Z, Wang S, Zhang X*, Wei S, Geisy J P, Yu H*. Influence of blooms of phytoplankton on concentrations of hydrophobic organic chemicals in sediments and snails in a hyper-eutrophic, freshwater lake, Water Research, 113: 22-31 2017
(2) Shi W, Guo J, Zhou Y, Deng D, Han Z, Zhang X*, Yu H*, Geisy J P. Phthalate Esters on Hands of Office Workers: Estimating Influence of Touching Surfaces. Environmental Science & Technology Letters, 4(1)：1-5 2017
(3) Wang X, Zhang X, Xia P, Zhang J, Wang Y, Zhang R, Giesy J P, Shi W*, Yu H*. A high-throughput, computational system to predict if environmental contaminants can bind to human nuclear receptors. Science of the Total Environment, 576: 609-616 2017
(4) Fang B, Guo J, Li F, Giesy J P, Wang L*, Shi W*. Bioassay directed identification of toxicants in sludge and related reused materials from industrial wastewater treatment plants in the Yangtze River Delta. Chemosphere, 168: 191-198 2017
(5) Chen Q, Wang X, Shi W*, Yu H*, Zhang X, Geisy J P, Identification of thyroid hormone disruptors among HO-PBDEs: In vitro investigations and co-regulator involved simulations. Environmental Science & Technology, 50(22)：12429-12438 2016
(6) Qu C, Shi W*, Guo J, Fang B, Wang S, Giesy J P, Holm P E, China’s Soil Pollution Control: Choices and Challenges, Environmental Science & Technology, 50 (24): 13181-13183 2016
(7) Shi W, Deng D, Wang Y, Hu G, Guo J, Zhang X, Wang X, Giesy J P, Yu H*, Wang Z. Causes of endocrine disrupting potencies in surface water in East China, Chemosphere, 144: 1435–1442 2016
(8) He X, Liu P, Zheng G, Chen H*, Shi W, Cui Y, Ren H, Zhang XX*. Evaluation of five microbial and four mitochondrial DNA markers for tracking human and pig fecal pollution in freshwater. Scientific Reports, 6:35311 2016
(9) SM Oskui, G Diamante, Liao C, Shi W, J Gan, D Schlenk, W.H.Grover*. Assessing and Reducing the Toxicity of 3D-Printed Parts. Environmental Science & Technology Letters, 3 (1):1–6 2016
(10) Hu X, Shi W*, Yu N, Jiang X, Wang S, Giesy J P, Zhang X, Wei S, Yu H*. Bioassay-directed identification of organic toxicants in water and sediment of Tai Lake, China, Water Research, 73(15), 231–241 2015
(11) He X, Chen H*, Shi W, Cui Y, Zhang XX*. Persistence of mitochondrial DNA markers as fecal indicators in water environments. Science of The Total Environment, 533:383-390 2015
(12) Hu G, Chen S, Shi W, Zhang B, Zhang Y, Huang J, Chen J, Giesy JP*, Yu H*. Identification of polycyclic aromatic hydrocarbons in soils in Taizhou, East China. Environmental Geochemistry and Health, 37(3):429–439 2015
(13) Yu N, Wang X, Zhang B, Yang J, Li M, Li J, Shi W, Wei S*, Yu H*. Distribution of perfluorooctane sulfonate isomers and predicted risk of thyroid hormonal perturbation in drinking water. Water Research, 76:171–180 2015
(14) Xia J, Su G, Zhang X*, Shi W, Giesy J P, Yu H. Dioxin-like activity in sediments from Tai Lake, China determined by use of the H4IIE-luc bioassay and quantification of individual AhR agonists, Environmental Science and Pollution Research, 21:1480–1488 2014
(15) Hu X, Shi W*, Wei S, Zhang X, Feng J, Hu G, Chen S, Giesy J P, Yu H*. Occurrence and potential causes of androgenic activities in source and drinking water in China, Environmental Science & Technology, 47 (18): 10591–10600 2013
(16) Wang X, Yang H, Hu X, Zhang X, Zhang Q, Jiang H, Shi W*, Yu H*. Effects of HO-/MeO-PBDEs on androgen receptor: In vitro investigation and helix 12-involved MD simulation, Environmental Science & Technology, 47 (2): 11802–11809 2013
(17) Shi W, Hu G, Chen S, Wei S, Cai X, Chen B, Feng J, Hu X, Wang X, Yu H*. Occurrence of estrogenic activities in second-grade surface water and ground water in the Yangtze River Delta, China, Environmental Pollution, 181: 31-37 2013
(18) Shi W, Wei S, Hu X, Hu G, Chen C, Wang X, Giesy J P, Yu H*. Identification of thyroid receptor ant/agonists in water sources using mass balance analysis and Monte Carlo simulation, Plos One, 8 (10): e73883 2013
(19) Hu X, Shi W*, Zhang Fn, Cao F, Hu G, Hao Y, Wei S, Wang X, Yu H*. In vitro assessment of thyroid hormone disrupting activities in drinking water sources along the Yangtze River. Environmental Pollution, 173: 210-215 2013
(20) Hu X, Shi W*, Cao F, Hu G, Hao Y, Wei S, Wang X, Yu H*. Bioanalytical and instrumental analysis of estrogenic activities in drinking water sources from Yangtze River Delta. Chemosphere, 90(7): 2123-2128 2013
(21) Li X, Ye L, Wang X, Shi W*, Liu H, Qian X, Zhu Y, Yu H*. In silico investigations of anti-androgen activity of polychlorinated biphenyls. Chemosphere, 92(7): 795-802 2013
(22) Li X, Ye L, Shi W*, Liu H, Liu C, Qian X, Zhu Y, Yu H*. In Silico study on hydroxylated polychlorinated biphenyls as androgen receptor antagonists. Ecotoxicology and Environmental Safety, 92(1): 258-264 2013
(23) Cao F, Li X, Ye L, Xie Y, Wang X, Shi W*, Qian X, Zhu Y, Yu H*. Molecular docking, molecular dynamics simulation, and structure-based 3D-QSAR studies on the aryl hydrocarbon receptor agonistic activity of hydroxylated polychlorinated biphenyls. Environmental Toxicology and Pharmacology, 36(2):626–635 2013
(24) Li X, Ye L, Wang X, Shi W*, Qian X, Zhu Y, Yu H*. Molecular modeling and molecular dynamics simulation studies on the interactions of hydroxylated polychlorinated biphenyls with estrogen receptor-β, Archives of Environmental Contamination and Toxicology, 65(3): 357-367 2013
(25) Yu N, Shi W, Zhang B, Su G, Feng J, Zhang X, Wei S*, Yu H*. Occurrence of perfluoroalkyl acids including perfluorooctane sulfonate isomers in Huai River basin and Taihu Lake in Jiangsu province, China, Environmental Science & Technology, 47 (2): 710-717 2013
(26) Wang X, Li X, Shi W, Wei S*, Giesy J P, Yu H*, Wang Y. Docking and CoMSIA studies on steroids and non-steroidal chemicals as androgen receptor ligands. Ecotoxicology and Environmental Safety, 89:143-149 2013
(27) Li X. Wang X, Shi W, Liu H. Yu H*. Analysis of Ah receptor binding affinities of polybrominated diphenyl ethers via in silico molecular docking and 3D-QSAR, SAR and QSAR in Environmental Research, 24(1) 75–87 2013
(28) Shi W, Hu X, Zhang F, Hu G, Hao Y, Zhang X, Liu H, Wei S, Wang X, Giesy J, Yu H*. Occurrence of thyroid hormone activities in drinking water from eastern China: Contributions of phthalate esters, Environmental Science & Technology, 46 (3): 1811-1818 2012
(29) Shi W, Zhang F, Hu G, Hao Y, Zhang X, Liu H, Wei S, Wang X, Giesy J P, Yu H*. Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta. Environment International, 42:117-123 2012
(30) Zheng XM, Liu HL*, Shi W, Wei S, Giesy JP, Yu HX*. Effects of perfluorinated compounds on development of zebrafish embryos. Environmental Science and Pollution Research, 19(7):2498–2505 2012
(31) 王玉婷，於紅霞，張效偉，史薇.基於毒性效應的間隙水致毒物質鑑別金屬進展.生態毒性學報.11(3):11-25 2016
(32) 鄧東陽,於紅霞,張效偉,史薇.基於毒性效應的非目標化學品鑑別技術進展.生態毒理學報.10(2):13-25 2015
(33) 郭婧，史薇，於紅霞，鄧東陽，王玉婷.以毒性效應為先導的有毒物質鑑別研究，南京大學學報.自然科學版. 50(4):414-424 2014 )
專利軟體
(1) 史薇，郭婧，於紅霞，Effect-oriented identification of targeted or non-targeted androgen disruptors. 2016.09.11, 美國, ZL 15/261985
(2) 於紅霞，史薇，陳欽暢，王小享. Screen methods for thyroid hormone disruptors based on co-regulator involved simulations. 2016.07.07 美國. ZL 15203877
(3) 史薇，鄧東陽，於紅霞，王玉婷. 一種以大型溞毒性為先導的農藥廢水中關鍵致毒物質鑑別方法，2016.04.13.中國, ZL 201410236171.4已授權。
(4) 於紅霞，史薇，陳欽暢，王小享. 基於核受體共調節因子的甲狀腺激素干擾物虛擬篩選及其干擾活性的定量計算方法. 2016.04.01.中國. 201610201950。
(5) 史薇，郭婧，於紅霞. 以效應為導向的目標/非目標雄激素干擾物鑑別方法.2016.04.21.中國.2016102523544。
(6) 於紅霞，史薇，王小享.基於分子動力學模擬的核受體介導內分泌干擾物質的虛擬篩選方法，2016.07.20. 中國，ZL 201310288617.3已授權。
(7) 史薇，於紅霞，王小享，胡欣欣，王玉婷. 水樣中關鍵擬/抗雄激素干擾毒物快速鑑別方法，2015.01.04,中國,ZL 201310539205.2已授權。
(8) 史薇，鄧東陽，於紅霞，王玉婷. 三唑類殺菌劑廢水中致毒手性單體的識別方法，2015.11.02.中國, 2015107337881.公開。
(9) 於紅霞，史薇，曹福，蘇冠勇，韋斯. 環境介質有機提取物同步純化並逐級分離的方法，2012.10.10，中國，ZL 200910232273.8已授權。
交流合作
(1)團隊有廣泛的國際合作交流，分別與美國、加拿大、德國、日本、芬蘭、香港等國家和地區的頂級環境科學研究機構開展實質性的科研合作與人員交流，取得豐碩成果。
(2) We would like to help academic researchers to predict the effective targets of studied compounds for free. System for Predicting Potential Effective Targets (SPET) is used to predict the endocrine systems-involved targets which can be activated by compounds, and the results can be further utilized to evaluate the healthy risk of these compounds. 91 targets related to endocrine systems (nuclear receptors, enzymes involved steroidogenesis, HPA/T/G Axis related proteins and other important targets) are adopted in this software. Research can send the structure of compounds (in the form of mol2 file or PDB file) to this and we will give the results back. In principle, we can only perform prediction on 5 compounds per month for each user. (Reference：Wang X, Zhang X, Xia P, et al. A High-throughput, Computational System to Predict if Environmental Contaminants Can Bind to Human Nuclear Receptors [J]. Science of The Total Environment, 2017, 576: 609-616.)
