劉鵬(武漢大學藥學院副副教授)

劉鵬：武漢大學藥學院副副教授

學習與工作簡歷：

2010-至今 武漢大學藥學院
2009-2010 香港大學 研究助理
2004-2008 香港大學 博士
2003-2004 香港大學 研究助理
2000-2003 蘭州大學 碩士
1996-2000 蘭州大學 學士

研究領域:

1. 抗病毒，抗腫瘤藥物及前體藥物的設計、合成與開發。

2. 具有生物活性的雜環化合物的合成方法研究。

承擔科研課題：

1） 主持武漢大學引進人才科研啟動經費，2013.1 – 2015.12;

2） 國家自然科學青年基金，2012.1-2014.12
代表論文：

1. Dingshan Zhou, Wei Tuo, Hao Hu, Jianrong Xu, Hongzhuan Chen, Zhigang Rao, Yuling Xiao, Xianming Hu, Peng Liu*.Synthesis and activity evaluation of tilorone analogs as potential anticancer agents. European Journal of Medicinal Chemistry,2013, 64, 432-441.

2. Yungen Liu, Xiangguo Guan, Ella Lai-Ming Wong, Peng Liu, Jie-Sheng Huang, and Chi-Ming Che. Nonheme Iron-Mediated Amination of C(sp3)−H Bonds. Quinquepyridine-Supported Iron-Imide/Nitrene Intermediates by Experimental Studies and DFT Calculations. J. Am. Chem. Soc., 2013,135, 7194.

3. Peng Liu, Yuxi Li, Haiyu Wang, Zhiming Wang, Xianming Hu. Synthesis of substituted quinolines by iron catalyzed oxidative coupling reactions. Tetrahedron Letters, 2012, 53, 6654-6656.

4. Hao Hu, Zhigang Rao, Jianrong Xu, Qingfu Zhu, Hans-Josef Altenbach, Hongzhuan Chen, Dingshan Zhou, Yuling Xiao, Xianbing Ke, Hao Guo, Zhongyuan Wu, Peng Liu*, Xianming Hu. 16-Morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: synthesis, biological evaluation and in silico probe of ligand-receptor interaction. European Journal of Medicinal Chemistry,2012, 332-347.

5. Peng Liu, Zhiming Wang,Jue Lin, Xianming Hu. An Efficient Route to Quinolines and Other Compounds by Iron Catalyzed Cross-Dehydrogenative Coupling Reactions on Glycine Derivatives.European Journal of Organic Chemistry2012, 1583-1589.

6. Peng Liu, Zhiming Wang, Xianming Hu. Highly Efficient Synthesis of Ureas and Carbamates from Amides by Iodosylbenzene Induced Hofmann Rearrangement.European Journal of Organic Chemistry 2012, 1994-2000.

7. Peng Liu, Yungen Liu, Ella Lai-Ming Wong, Song Xiang, Chi-Ming Che. Iron Oligopyridine Complexes as Efficient Catalysts for Practical Oxidation of Arenes, Alkanes, Tertiary Amines and N-Acyl Cyclic Amines with Oxone. Chemical Science2011, 2, 2187-2195.

8. Hao Guo, Guolan Zhang, Tao Zhang, Xianran He, Zhongyuan Wu, Yuling Xiao, Yuanhu Pan, Guofu Qiu, Peng Liu, Xianming Hu. Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents. European Journal of Medicinal Chemistry 2011, 9, 3662-3674.

9. Peng Liu, Cong-Ying Zhou, Song Xiang, Chi-Ming Che. Highly Efficient Oxidative Carbon-Carbon Coupling with SBA-15-Supported Iron Terpyridine Catalyst. Chemical Communications 2010, 46, 2739-2741.

10. Peng Liu, Ella Lai-Ming Wong, Angella Wing-Hoi Yuen, Chi-Ming Che. Highly Efficient Alkene Epoxidation and Aziridination Catalyzed by Iron(II) Salt +4,4′,4′′-Trichloro-2,2′:6′,2′′-terpyridine/4,4′′-Dichloro-4′-O-PEG-OCH3-2,2′:6′,2′′-terpyridine. Organic Letters 2008, 10, 3275-3278.

11. Wing-Kei Chan, Peng Liu, Man-Kin Wong, Chi-Ming Che. Highly Diastereoselective Epoxidation of Allyl-Substituted Cycloalkenes Catalyzed by Metalloporphyrins. Organic Letters2004, 6, 1597-1599.

授權專利：

1. 胡先明，郭豪，劉鵬，16-唑取代-3胺取代-5α雄甾烷衍生物及其製備方法和套用，專利號：ZL201110050236.2.

申請專利：

1. 胡先明，郭豪，劉鵬，16-取代-3雜環-5a雄甾烷衍生物及其製備方法和套用，申請號：201110050268.2

2. 胡先明，肖玉玲，周小菊，劉鵬，茯苓三萜在製備保肝護肝藥物上的套用，申請號：201110433742.X

3. 胡先明，汪志明,劉鵬，一種1,3-二取代脲和氨基甲酸酯簡便高效的合成方法，申請號：201110358701.9

4. 胡先明，胡昊，饒志剛，劉鵬，肖玉玲，3，16β-二胺基甾體季銨鹽衍生物及其製備方法和套用，申請號：201210151149.0

5. 胡先明，胡昊，饒志剛，劉鵬，肖玉玲，4,16β-二胺基甾體季銨鹽衍生物及其製備方法和套用，申請號：201210151370.6

國際國內學術會議及報告:
1. 2012年8月, 第八屆世界華人藥物化學研討會分會報告, Design, synthesis and in vivo neuromuscular blocking activity of aminosteroid derivatives。