劉路，男，新加坡國立大學博士。上海交通大學農業與生物學院長聘教軌副教授。
基本介紹
教育背景,工作經歷,研究方向,主要成就,所獲榮譽,
教育背景
2004-2008 雲南大學，本科
2008-2013 新加坡國立大學，博士
工作經歷
2012-2013 淡馬錫生命科學研究所，新加坡，初級研究員
2013-2020 淡馬錫生命科學研究所，新加坡，博士後研究員
2020.06-至今 上海交通大學，農業與生物學院，長聘教軌副教授
研究方向
植物作為一個多細胞生物個體，它利用可移動的信號分子（如信號肽、RNA、激素、蛋白質等）來完成細胞間信息的傳遞，以此適應不斷變化的外界環境。近些年，越來越多的證據表明，跨細胞運輸的轉錄調控因子對植物自身形態建成及生長發育的精準調控發揮著極其重要的作用。對此類轉錄調控因子進行細胞生物學和分子生物學的深入研究，了解其跨細胞運輸的調控方式，將對未來農業的發展帶來積極的促進效果。
綜合運用分子遺傳學、系統生物學、細胞生物學和生物顯微影像學等手段，解析生物大分子在細胞間和細胞內的運輸對植物生長發育、自身形態建成以及回響外界環境的影響。主要研究方向如下：
1. 植物開花素和開花抑制素的調控、轉運及作用機制；
2. 植物大分子蛋白在細胞內轉導及跨細胞運輸對植株形態建成的影響；
3. 植物蛋白轉運在時間和空間上的調控，以及對外界環境和植物內源激素的回響；
4. Multiple C2 Domain and Transmembrane Region Proteins (MCTPs)家族蛋白在植物膜轉運系統中的功能。
主要成就
發表論文：
- Liu Lu#, Zhang Yu, Yu Hao# (2020) Florigentrafficking integrates photoperiod and temperature signals inArabidopsis. Journal of Integrative Plant Biology 62:1385-1398. (# co-correspondingauthor)
- Li Chunying*, Liu Lu*, Teo Zhi Wei Norman, Shen Lisha, Yu Hao(2020) Nucleoporin 160 regulates flowering through anchoring HOS1 fordestabilizing CO in Arabidopsis. PlantCommunications 1, 100033. (* these authors contributed equally)
- Liu Lu, Li Chunying, Teo Zhi Wei Norman, Zhang Bin, Yu Hao(2019) The MCTP-SNARE complex regulates florigen transport inArabidopsis. Plant Cell 31:2475-2490.（Issue Highlights）
- Liu Lu, Li Chunying, Song Shiyong, Teo Zhi Wei Norman, ShenLisha, Wang Yanwen, Jackson David, Yu Hao (2018) FTIP-dependent STM traffickingregulates shoot meristem development in Arabidopsis. Cell Reports 23: 1879-1890. (Featured in Facultyof 1000 Biology)
- Liu Lu, Li Chunying, Liang Zhe, Yu Hao (2018) Characterizationof multiple C2 domain and transmembrane region proteins in Arabidopsis. Plant Physiology 176: 2119-2132.
- Liu Lu, Zhu Yang, Shen Lisha, Yu Hao (2013). Emerging insightsinto florigen transport. Current Opinion in Plant Biology 16: 607-613.
- Liu Lu*, Liu Chang*, Hou Xingliang, Xi Wanyan, Shen Lisha, TaoZhen, Wang Yue, Yu Hao (2012). FTIP1 is an essential regulator required forflorigen transport. PLoS Biology 10: e1001313. (* these authors contributedequally) (Issue Highlights; Featured in Faculty of 1000 Biology; Embodied inPlant Physiology and Development, Sixth Edition)
- Song Shiyong, Chen Ying, Liu Lu, See Yen How Benjamin, Mao Chuanzao, GanYinbo, Yu Hao (2018) OsFTIP7 determines auxin-mediated anther dehiscence inrice. Nature Plants 4: 495-504.
- Wang Yanwen, Liu Lu, Song Shiyong, Li Yan, Shen Lisha, Yu Hao(2017) DOFT and DOFTIP1 affect reproductive development in the orchidDendrobium Chao Praya Smile. Journal of Experimental Botany 68: 5759-5772.
- Song Shiyong, Chen Ying, Liu Lu, Wang Yanwen, Bao Shengjie, Zhou Xuan,Teo Zhi Wei Norman, Mao Chuanzao, Gan Yinbo, Yu Hao (2017) OsFTIP1-mediatedregulation of florigen transport in rice is negatively regulated by theubiquitin-like domain kinase OsUbDKγ4. Plant Cell 29: 491-507.
- Zhu Yang, Liu Lu, Shen Lisha, Yu Hao (2016) NaKR1regulates long-distance movement of FLOWERING LOCUS T in Arabidopsis. Nature Plants 2: 16075.( Featured in Faculty of1000 Biology)
- Shen Lisha, Liang Zhe, Gu Xiaofeng, ChenYing, Teo Zhi Wei Norman, Hou Xingliang, Cai Weiling Maggie, Dedon PerterC., Liu Lu, Yu Hao (2016) N6-methyladenosine RNA modificationregulates shoot stem cell fate in Arabidopsis. DevelopmentalCell 38: 186-200.
- Hou Xingliang, Zhou Jiannan, LiuChang, Liu Lu, Shen Lisha, Yu Hao (2014) Nuclear Factor Y-mediatedH3K27me3 demethylation of the SOC1 locus orchestrates flowering responses ofArabidopsis. Nature Communications 5: 4601.
- Tao Zhen, Shen Lisha, Liu Chang, Liu Lu, Yan Yuanyuan, Yu Hao (2012). Genome-wideidentification of SOC1 and SVP targets during the floral transition inArabidopsis. Plant Journal 70:549-561.
- Shen Lisha, Kang Yin Ga Germain, Liu Lu, Yu Hao (2011) The J-domain protein J3mediates the integration of flowering signals in Arabidopsis. Plant Cell 23, 499-514.
- Fang Lei, Hou Xingliang, Lee Li YenCandy, Liu Lu, Yan Xiaojing, Yu Hao (2011). AtPV42a and AtPV42bredundantly regulate reproductive development in Arabidopsis thaliana. PLoS One 6: e19033.
所獲榮譽
2013: Gold Medal of International Society of Plant Molecular Biology, National University of Singapore
2010: Excellent Teaching Assistant Award AY 2009/2010, National University of Singapore
