社會兼職
中國畜牧獸醫學會動物繁殖學分會秘書長 ;
奶牛產業體系北京市創新團隊繁育功能室主任;
研究方向
家畜配子和
胚胎髮育調控機制和繁殖技術,近年來在褪黑素(Melatonin, MT)調控卵母細胞成熟、顆粒細胞黃體化、早期胚胎髮育與附植的理論研究中取得突破性進展,並將研究成果在家畜生產中套用;建立了褪黑素過表達羊乳腺反應器平台。
教學工作
研究生教學課程:動物生殖生理學、動物繁殖與胚胎工程技術實踐、家畜繁殖管理與案例分析
出版圖書
作者名稱:劉國世
作者類型:
作者時間:2008年3月1日
《奶牛配種員培訓教材》是2008年金盾出版社出版的圖書,作者是劉國世、朱士恩。
學術成果
科研工作
國家自然基金面上項目,31372306,褪黑素通過LIF調控小鼠胚胎附植的研究,2014-2017;
國家自然基金面上項目,31172177,褪黑素及其受體促進小鼠卵母細胞成熟的信號通路研究,2012-2015;
973課題,2014CB138500,豬繁殖力的生理學及相關遺傳調控機理,2014-2018;
國家
生物育種重大專項重點項目,2010ZX08008-002B,利用睡美人轉座系統提高轉基因羊製備效率,2009-2012;
農業部“十二五支撐計畫項目,2011BAD19B02-4,牛羊高效超排與克隆胚胎生產技術研究與示範,2011-2013;
國家
生物育種重大專項重點項目,2014ZX08008-002B,強化褪黑素功能乳轉基因奶山羊新品種的培育,2014-2016;
新世紀優秀人才支持計畫,NETC-10-0782,2011-2013;
北京市產業體系計畫,2011BAD19B01,北京市奶牛產業體系創新團隊,2012-2021;
北京市自然科學基金,6122019,褪黑素促進牛卵母細胞體外成熟的分子機制研究,2012-2014;
新疆維吾爾自治區科技廳支疆項目,2016E02037,“黑薩福克與多浪羊雜交改良與快速繁育技術研究與套用,2016-2018
中國農業大學與
新疆農業大學合作基金,2015TC050,“試管”綿羊生產過程中早期胚胎體外發育技術體系最佳化研究與套用,2015-2016。
發表論文
He C, Ma T, Shi J, Zhang Z, Wang J, Zhu K, Li Y, Yang M, Song Y, Liu GS(*). Melatonin and its receptor MT1 are involved in the downstream reaction to luteinizing hormone and participate in the regulation of luteinization in different species. J Pineal Res,2016, 61(3):279-90.
He C, Wang J, Zhang Z, Yang M, Li Y, Tian X, Ma T, Tao J, Zhu K, Song Y, Ji P ,Liu GS(*). Mitochondria Synthesize Melatonin to Ameliorate Its Function and Improve Mice Oocyte's Quality under in Vitro Conditions. Int J Mol Sci,2016,14;17(6) :939-45.
Li Y, Wang J, Zhang ZZ, Yi JY, He CJ, Wang F, Tian XZ, Yang MH, Song YK, He PL, Liu GS(*). Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress. J Pineal Res,2016,7(1):1-10
Deng SL,Chen SR, Wang ZP,Zhang Y, Tang JX, Li J,Wang XX,Cheng JM, Jin C, Li XY,Zhang BL,Yu K,Lian ZX,Liu GS(*),Liu YX(*). Melatonin promotes development of haploid germ cells from early developing spermatogenic cells of Suffolk sheep under in vitro condition. J Pineal Res,2016,60(4):435-47.
Shi JM, Yi JY, Tian XZ, Wang F, Lian ZX, Han HB, Fu JC, Lv WF, Liu GS(*).Effects of seasonal changes on the ovulation rate and embryo quality in superovulated Black Suffolk ewes.Neuro Endocrinol Lett,2015,36(4):330-336。
He CJ, Wang J, Li Y, Zhu KF, Xu ZY, Song YL, Song YK, Liu GS(*). Melatonin-related genes expressed in the mouse uterus during early gestation promote embryo implantation. J Pineal Res,2015,58(3):300-309.
Li Y, Zhang ZZ, He CJ, Zhu KF, Xu ZY, Ma T, Tao JL, Liu GS(*). Melatonin protects porcine oocyte in vitro maturation from heat stress. J Pineal Res,2015,59(3):365-75.
Wang F,Tian XZ,Zhang L,Gao C,He CJ,Fu Y,Ji PY,Li Y,Li N,Liu GS(*). Beneficial effects of melatonin on in vitro bovine embryonic development are mediated by melatonin receptor 1. J Pineal Res,2014,b, 56(3):333-342.
Tian XZ,Wang F,He CJ,Zhang L,Tan DX,Reiter RJ,Xu J,Ji PY,Liu GS(*). Beneficial effects of melatonin on bovine oocytes maturation: a mechanistic approach. J Pineal Res,2014,57( 3):239-247.
Wang F,Tian XZ,Zhou YH,Tan DX,Zhu SE,Dai YP,Liu GS(*). Melatonin Improves the Quality of In Vitro Produced (IVP) Bovine Embryos: Implications for Blastocyst Development, Cryotolerance, and Modifications of Relevant Gene Expression.PLos One,2014,9(4):1-7.
Wang L,Zhuo ZY,Shi WQ,Tan DX,Gao C,Tian XZ,Zhang L,Zhou GB,Zhu SE,Yun P(*), Liu GS(*). Melatonin Promotes Superovulation in Sika Deer (Cervus nippon). Int J Mol Sci,2014,15(7):12107-12118.
Fu Y,He CJ,Ji PY,Zhuo ZY,Tian XZ,Wang F,Tan DX,Liu GS(*).Effects of Melatonin on the Proliferation and Apoptosis of Sheep Granulosa Cells under Thermal Stress. Int J Mol Sci,2014,15(11):21090-21104.
Wang L,Zhao Y,Reiter RJ,He C,Liu GS,Lei Q,Zuo B, Zheng XD,Li Q,Kong J(*). Changes in melatonin levels in transgenic 'Micro-Tom' tomato overexpressing ovine AANAT and ovine HIOMT genes. J Pineal Res,2014,56(2):134-142.
Wang F,Tian XZ,Zhang L,He CJ,Ji PY,Li Y,Tan DX,Liu GS(*) ,Beneficial effect of resveratrol on bovine oocyte maturation and subsequent embryonic development after in vitro fertilization.Fertil Steril,2014,101( 2 ):577-586.
Wang F,Tian XZ,Zhang L,Tan DX,Reiter RJ.,Liu GS(*) ,Melatonin promotes the in vitro development of pronuclear embryos and increases the efficiency of blastocyst implantation in murine. J Pineal Res,2013,55(3):267-274.
Zhang L,Chai ML,Tian XZ,Wang F,Fu Y,He CJ,Deng SL,Lian ZX,Feng JZ,Tan DX,Liu GS(*) ,Effects of melatonin on superovulation and transgenic embryo transplantation in small-tailed han sheep (Ovis aries). Neuroendocrinol Lett,2013,34(4):294-301.
Wang L.,Zhou GB,Shi WQ,Shi JM,Tian XZ,Gao C,Zhang L,Zhu SE,Zhang TT,Zeng SM,Liu GS(*) ,First live offspring born in superovulated sika deer (Cervus nippon) after embryo vitrification .Theriogenology,2012,78(7):1627-1632.
Gao C,Han HB,Tian XZ,Tan DX,Wang L,Zhou GB,Zhu SE,Liu GS(*) ,Melatonin promotes embryonic development and reduces reactive oxygen species in vitrified mouse 2-cell embryos. J Pineal Res,2012,52(3):305-311.
Tian XZ,Wen Q,Shi JM,Wang L,Zeng SM,Zhou GB,Zhu SE,Liu GS(*) ,Effects of Melatonin on In Vitro Development of Mouse Two-Cell Embryos Cultured in HTF Medium. Endocr Res,2010,35(1):17-23.
Suo L,Wang F,Zhou GN,Shi JM,Wang YM,Zhen SM,Tian JH,Zhu SE,Liu GS(*) ,Optimal Concentration of Calcium and Electric Field Levels Improve Tetraploid Embryo Production by Electrofusion in Mice. J Reprod Develop,2009,55(4):383-385.
Zhou GB, Ma CB, Liu GS(*), Zhu SE(*), Zhang HH, Jia LL, Suo L, Shi JM, Wang YB, Tian JH, Zeng SM,Vitrification of farmed blue fox oocytes in ethylene glycol and DMSO-based solutions using open-pulled straw (OPS).Cryoletters,2009,30(2):112-8.
Zhou GB(*), Liu GS(*), Meng QG, Liu Y, Hou YP, Wang XX, Li N, Zhu SE,Tetraspanin CD9 in bovine oocytes and its role in fertilization. J Reprod Develop ,2009,55(3):305-8.
Shi JM, Tian XZ, Zhou GB, Wang L, Gao C, Zhu SE, Zeng SM, Tian JH, Liu GS(*),Melatonin exists in porcine follicular fluid and improves in vitro maturation and parthenogenetic development of porcine oocytes. J Pineal Res,2009,47(4):318-23.
Liu GS(*), Zhou GB, Zhang HH(*), Ma CB, Shi WQ, Zhu SE, Yang ZQ, Kang J, Jia LL, Zeng SM, Tian JH, Wang F,Surgical embryo transfer resulted in birth of live offspring in farmed blue fox. Anim Reprod Sci ,2008,05(3-4):424-9
發明專利
一種促進冷凍胚胎解凍後體外發育的培養液 ZL 201110142477.X
單酶切載體的構建方法 ZL 201410246859.0
一種提高羊超數排卵數量與質量的方法 ZL 2015100849978
一種降低家畜體細胞數的複合抗氧化製劑及其製備方法與套用
201510085041X(中國) PCT/CN2015/097907(國際)
一種提高奶牛受胎率的製劑及其製備方法與套用 2015100850439
一種延緩雌性動物生殖機能衰退的方法201610073605.2
一種提高多胎動物產仔數的方法 201510375418.5
一種提高產蛋禽類產蛋率的方法 2015100850443
一種提高大齡動物繁殖力的方法 201510954821.3
發表著作
制定標準
“梅花鹿胚胎移植技術規程”(DB11/T 960-2013)批准日期2013-01-31,實施日期2013-05-01.
“梅花鹿人工授精技術規程”(DB11/T 961-2013)批准日期2013-01-31,實施日期2013-05-01
獲得榮譽
2010年 教育部新世紀優秀人才支持計畫;
2011年 梅花鹿、馬鹿
人工授精技術與性別控制精液的示範與推廣 北京市農業推廣獎二等獎;
2012年 狐狸高效繁殖技術體系的研究與套用 山東省科學技術三進步獎;
2008年 套用胚胎生物技術對北極狐(藍狐)進行保種的技術研究 山東省科學技術三進步獎;
2004年 牛羊胚胎工程產業化技術體系的研究與套用 教育部
科學技術進步獎二等獎。
2023年 北京高校優秀黨務工作者