1. 發展光功能導向的矽納米材料,並將其作為納米生物螢光探針,用於生物成像研究,為重大疾病(如癌症)的早期檢測與診斷提供新工具。相關工作為國際權威期刊系列收錄(2篇J. Am. Chem. Soc.,2篇Angew. Chem. Int. Ed.),並以VIP、封頁文章報導,被Nature Asia Materials、ChemistryViews等國際知名媒體做專題報導;
2. 發展一系列具有複合功能的矽基納米雜化材料,並將其套用於生物感測分析檢測和癌症治療等方面,為癌症的早期與治療提供新方法。相關工作為國際知名雜誌系列收錄(1篇Nano Lett.,1篇Nano Today., 1篇Adv. Mater.,1篇ACS Nano),並被Nature、Nature Asia Materials等國際著名媒體做專題報導。
3. 發展從可見光到近紅外發光的不同結構水分散性量子點,實現近紅外水分散性螢光量子點在小鼠體內的腫瘤高靈敏靶向檢測,並對其毒理學和安全性進行研究。相關工作為國際著名雜誌收錄(1篇Angew. Chem. Int. Ed., 3篇Biomaterials)。國際知名雜誌Nanomedicine將該研究列入專門報導“the most important events and research in the field of nanomedicine(納米醫學領域最重要的研究結果)”的“News & Views(新聞與觀點)”部分進行專題報導。
1. Yuanyuan Su, Xinpan Wei, Fei Peng, Yiling Zhong, Yimei Lu, Shao Su, Tingting Xu, Shuit-Tong Lee*, Yao He*. "Gold nanoparticles-decorated silicon nanowires as highly efficient near-infrared hyperthermia agents for cancer cells destruction" Nano Lett. in press (DOI: nl-2011-04203t)
2. Shao Su, Xinpan Wei, Yiling Zhong, Yuanyuan Guo, Yuanyuan Su, Qing Huang, Shuit-Tong Lee*, Chunhai Fan*, Yao He*. "Silicon nanowire-based molecular beacons for high-sensitivity and sequence-specific DNA multi-analysis" ACS Nano in press (DOI: nn-2011-050449)
3. Yao He*, Yiling Zhong, Fei Peng, Xinpan Wei, Yuanyuan Su, Yimei Lu, Shao Su, Wei Gu, Liangsheng Liao, Shuit-Tong Lee*. "One-Pot Microwave Synthesis of Water-Dispersible, Ultraphoto and pH Stable, and Highly Fluorescent Silicon Quantum Dots" J. Am. Chem. Soc. 2011, 133, 14192-14195.
4. Yao He*, Yiling Zhong, Yuanyuan Su, Yimei Lu, Ziyun Jiang, Fei Peng, Tingting Xu, Shao Su, Qing Huang, Chunhai Fan*, Shuit-Tong Lee*. "Water-Dispersed Near-Infrared-Emitting Quantum Dots of Ultrasmall Sizes for in Vitro and in Vivo Imaging" Angew. Chem. Int. Ed. 2011, 123, 5813-5816.
5. Yao He*, Shao Su, Tingting Xu, Yiling Zhong, J. Antonio Zapien, Jiang Li, Chun-Hai Fan*, Shuit-Tong Lee*. "Silicon nanowires-based highly-efficient SERS-active platform for ultrasensitive DNA detection" Nano Today 2011, 6, 122-130.
6. Yao He*, Yiling Zhong, Fei Peng, Xinpan Wei, Yuanyuan Su, Shao Su, Wei Gu, Liangsheng Liao, Shuit-Tong Lee*. "Highly luminescent water-dispersible silicon nanowires for long-term immunofluorescent cellular imaging" Angew. Chem. Int. Ed. 2011, 50, 3080-3083.(Back Cover, VIP, highlighted by Nature Asia Materials and ChemistryViews)
7. Yuanyuan Su, Fei Peng, Ziyun Jiang, Yiling Zhong, Yimei Lu, Xiangxu Jiang, Qing Huang, Chunhai Fan*, Shuit-Tong Lee*, Yao He*. "In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots" Biomaterials 2011, 32, 5855-5862. (Highlighted by Nanomedicine Nanomedicine 2011, 5, 765.)
8. Yao He*, Chunhai Fan*, Shuit-Tong Lee*. "Silicon nanostructures for bioapplications" Nano Today 2010, 5, 282-295. (invited review, ranked the 4th in the 25 hottest papers in the journal on Science Direct)
9. Yao He, Yuanyuan Su, Xiaobao Yang, Zhenhui kang, Tingting Xu, Ruiqin Zhang, Chuihan Fan*, Shuit-Tong Lee*. "Photo and pH Stable, Highly Luminescent Silicon Nanospheres and Their Bioconjugates for Immunofluorescent Cell Imaging" J. Am. Chem. Soc. 2009, 131, 4434-4438. (Cover)
10.Yao He, Zhenhui Kang, Quansong Li, Chi Him A. Tsang, Chunhai Fan*, Shuit-Tong Lee*. "Ultrastable, Highly Fluorescent, and Water-Dispersed Silicon-Based Nanospheres as Cellular Probes" Angew. Chem. Int. Ed. 2009, 48, 128-132. (Inside Cover, highlighted by Nature Asia Materials)